Professor HO Wing Shing John

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Education

1985 Ph.D. State University of New York Buffalo
  M.A. State University of New York Buffalo
  B.Sc. University of Alberta

Position

  • Adjunct Associate Professor, School of Life Sciences

Research Interests

  • Chemical Carcinogenesis
  • Natural products of herbal medicines and cancer
  • Detoxifying Enzymes  

Representative Publications

  • Chen Wen Yang; Ho Wing Shing John; Huang Jian Dong and Watt Rory M
    Functional Characterization of an Alkaline Exonuclease and Single Strand Annealing Protein from the SXT Genetic element of Vibrio Cholerae. BMC Mol Biol 12, 00-15, 2011.
  • Ho, J.W., Lee, N.H.P., Chim, W.O. Effects of oxymatrine from Ku Shen on cancer cells. Anti-cancer Agents Med Chem. 9(8), 823- 828, 2009.
  • Lee N.H. and Ho, J.W. Celastrol and terpenes as anti-infective agents. Anti-infective Agents in Medicinal Chemistry. 7(2), 97-104, 2008.
  • Ho, J.W. and Meng Jie. Pharmacological activity of cardiovascular agents from herbal medicine.
    Cardiovasc and Hematol Agents Med Chem. 5(4), 273 -277, 2007
  • Ho, J.W., Recent advances in protein and peptide chemistry related to cellular regulation. Protein & Peptide Lett. Vol. 13 (5), 533 pages, 2006.
  • Leung, Y.K. and Ho, J.W. Deciphering signaling control by phosphoproteome using mass spectrometry. Prot. & Peptide Lett. 13(5), 467-470, 2006.
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Wong, K.F., Ho, J.W. Identification of histidine-60 interaction with copper in activation of chironomidae ferrochelatase Prot. & Peptide Lett. 13(5), 443-446, 2006.
  • Leung, Y.K. and Ho, J.W. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochem. Pharmacol. 63(4), 767-775, 2002.

Research Grants

  • 2009 - 2010, ITC, Establishment of platform for R&D of naturally occurring small molecules for liver cancer therapy, $674,268
  • 2009 - 2011 Contract, R&D of Naturally occurring molecules for disorder & cancer therapy, $1,800, 000
  • 2009 – 2011,GRF, Is Adolescent Idiopathic Scoliosis and Its Accompanying Low Bone Mass Associated with Vitamin-D Insufficiency? – A Case-control Study, Co-I, $498,201

Patents

  • Ho, J.W. and Lau, V. Methods for treatment and/or prevention of liver cancer with andrographolide (and) use thereof. US 08C10485.
  • Ho, J.W. A Method and composition for treatment and/or prevention of gastric ulceration and use thereof . US patent no. 08C10484US.
  • Ho, J.W., Meng, J. Compositions and Methods for treating cancer. CN2008_000460.

Awards

  • Leung Y. K. and Ho, J.W. Effects of licorice on the expression of UGT1A isozymes in rat hepatoma cells.
    FASEB J. 14(8), May 11, 2000. Boston, Annual Meeting of American Society for Biochemistry and Molecular Biology [ASBMB]
  • Leung, Y.K. and Ho, J.W. Induced expression of UDP-glucuronosyltransferase 1A8 in rat liver cells by aqueous licorice root extract.
    15th Symposium of the Protein Society, Philadelphia, July 28-Aug. 1, 2001.

Professional Activities

  • Guest Editor, Protein & Peptide Letters
  • Editor Board member,
    1. Chinese Journal of Medicine;
    2. Anti-Cancer Agents in Medicinal Chemistry;
    3. Recent Patents on Anti-Cancer Drug Discovery.
  • Reviewer, Analytical Chemistry (73 papers have been reviewed)