Dr LAU Wilson Chun Yu

Address
(Office): Room 219B, Run Run Shaw Science Building

(Lab): Room LG101 & LG103, Run Run Shaw Science Building
 
 People wilsonlau
Phone
(Office): (852) 3943 6253

(Lab): (852) 3943 6379
 
Fax 
Email
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Education

2012     Ph.D., University of Toronto
2006     H.B.Sc., University of Toronto

Position

  • Research Assistant Professor, School of Life Sciences

Research Interests

  • Single-particle cryo-electron microscopy (cryo-EM)
  • Structure-function of macromolecular assemblies and membrane proteins
  • Therapeutic interventions
  • Plant biotechnology

Representative Publications

  1. Lau, W.C.Y., Li, Y., Liu, Z., Gao, Y., Zhang, Q. and Huen, M.S.Y. (2016). Structure of the human dimeric ATM kinase. Cell Cycle, 15, 1117-24.
  2. Roh, S., Kasembeli, M., Galaz-Montoya, J.G., Trnka, M., Lau, W.C.Y., Burlingame, A., Chiu, W. and Tweardy, D.J. (2016). Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. Journal of Biological Chemistry, 291, 4732-41.
  3. Lau, W.C.Y., Li, Y., Zhang, Q. and Huen, M.S.Y. (2015). Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA. Scientific Reports, 5, 15759.
  4. Kasembeli, M., Lau, W.C.Y., Roh, S., Eckols, Frydman, J., Chiu, W. and Tweardy, D.J. (2014). Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin. PLOS Biology, 12(4):e1001844.
  5. Lau, W.C.Y. and Rubinstein, J.L. (2013). Single particle electron microscopy. Methods in Molecular Biology, 955, 401-26.
  6. Lau, W.C.Y. and Rubinstein, J.L. (2012). Subnanometer-resolution structure of the intact T. thermophilus H+-driven ATP synthase. Nature, 481, 214-218 (Recommended by Terrence Frey; Recognized by F1000Prime).
  7. Lau, W.C.Y. and Rubinstein, J.L. (2009). Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound V(O) motor. Proceedings of the National Academy of Sciences, 107, 1367-72 (Recommended by Thomas Meier; Recognized by F1000Prime).
  8. Lau, W.C.Y., Baker, L.A. and Rubinstein, J.L. (2008). Cryo-EM structure of the yeast ATP synthase. Journal of Molecular Biology, 382, 1256-1264 (Journal cover).

Research Grants

  • 2015, Seed Funding Programme for Applied Research (Co-I), The University of Hong Kong, Exploiting the potential of cryo-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases., $100,000
  • 2015-2016, Small Project Fund, The University of Hong Kong, Structural role of the BRCA1-PALB2-BRCA2 complex in DNA repair., $39,039

Award

  • AXA Research Fund Postdoctoral Fellowship, The University of Hong Kong, Hong Kong, 2015-2017 (AR140003)
  • University of Hong Kong/China Medical Board Grants, The University of Hong Kong, Hong Kong, 2015
  • State Key Laboratory of Brain and Cognitive Sciences research fund, The University of Hong Kong, Hong Kong, 2015
  • URC/CRCG – Conference Support for Teaching Staff, The University of Hong Kong, Hong Kong, 2015 (201507170299)
  • Keck Center for Interdisciplinary Biosciences Training of the Gulf Coast Consortia, Cancer Prevention and Research Institute of Texas (CPRIT) postdoctoral Computational Cancer Biology training grant (RP101489), Baylor College of Medicine, United States of America, 2013-06 to 2014-06 (NIH Level 1 Equivalent)
  • Cancer Prevention and Research Institute of Texas (CPRIT) postdoctoral research training grant (RP101499), Baylor College of Medicine Comprehensive Cancer Training Program, Baylor College of Medicine, United States of America, 2012-06 to 2013-06

Professional Activitiy

Previous positions

  • 2014-2016 Postdoctoral fellow, School of Biomedical Sciences, HKU
  • 2012-2014 Postdoctoral fellow, National Center for Macromolecular Imaging, Baylor College of Medicine, USA