Address	(Office): Room 184, Science Centre South Block (Lab): Room 116, Run Run Shaw Science Building
Phone	(Office): (852) 3943 4420 (Mobile): (852) 9412 6791 (Lab): (852) 3943 1217
Fax	(852) 2603 5391
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.
On-going projects	https://www.dropbox.com/s/8nsd3rnuu7i29kr/KMCHAN%20Research%20Projects%202017.pptx?dl=0

Education

Position

• Director, Environmental Science Program
• Associate Professor, School of Life Sciences
• Warden, Student Hostel 2, Shaw College

Research Interests

• Aquatic Toxicology
• Molecular Endocrinology
• Marine Biotechnology
• Environmental Policy  

Representative Publications

(out of 85 full papers in peer-reviewed international journals, 5 book chapters and over 168 abstracts or proceeding papers presented in international conferences; Hi Index 31 (19 since 2012), citations = 2460):

1. Chen, Y.Y., and Chan, K.M. (2018) Transcriptional inhibition of TCDD induced gene expression and protein expression profiles in zebrafish following the administrations of TCDD and cadmium. Toxicology Letters 282:121-135. (LINK)
2. Yang, J., Zhao, H., and Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47, and 99) and localization of BDE-99 induced cyp1 mRNA in zebrafish larvae. Toxicology Reports 4: 614-624. (LINK)
3. Zhou, Z., Yang, J., and Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquat. Toxicology 191: 175-188.
4. Tsang, Y.Y., Mack, C.W., Liebich, C., Lam, S.W., Sze, E. T-P., Chan, K.M. (2017) Microplastic pollution in marine waters and sediments of Hong Kong. Marine Pollution Bulletin 115:20-28.
5. Yang, J., Zhu, J., and Chan, K.M. (2016) BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells. Toxicol. Appl. Pharmacol. 305: 203-215.
6. Chen, Y.Y., and Chan, K.M. (2016) Modulation of the expression of estrogen receptor pathway related genes by TCDD, Cd2+ and mixtures of Cd2+ and TCDD in zebrafish. Chemosphere 147: 467-476.
7. Yang, J., and Chan, K.M. (2015) Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aq. Toxicol. 159:138-147.
8. Chen, Y.Y., Zhu, J.Y., and Chan, K.M. (2014) Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells. Aq. Toxicol. 157: 196-206.
9. Leung, K.P., Chen, D.S., and Chan, K.M. (2014) Understanding copper sensitivity in zebrafish (Danio rerio) through tissue expression profiles and intracellular localization of copper transporters. Metallomics 6: 1057-1067.
10. Chan, W.K-L., and Chan, K.M. (2012) Effects of BDE-47, TBBPA and BPA on the hypothalamic-pituitary-thyroid axis in zebrafish embryo-larvae. Aq. Toxicol. 108:106-111.

Research Grants

• 1993-95, Cloning of growth hormone-like gene in economically important invertebrates, CUHK Research Committee Funding, HKD $100,000, BP92018.
• 1993, Bacterial expression of biosynthetic fish insulin-like growth factor, CUHK Research Committee Funding, HKD $ 25,700, MD92050.
• 1993-96, Somatolactin: studies on its expression in a bacterial system, its physiological functions and molecular mechanism of action in teleosts, Research Grant Council Earmarked Grant Funding, with Drs T.B. Ng and T.T. Chen., HKD $ 616,000, CUHK17/93M. Results ranked as SATISFACTORY by RGC.
• 1995-97, On the use of fish metallothionein levels as biomarker (I): development of sensitive immunoassay and polymerase chain reaction based assay to detect metallothionein gene expression in tilapia tissues, Research Grant Council Earmarked Grant Funding, HKD $ 682,000, CUHK355/95M. Results ranked as SATISFACTORY by RGC.
• 2004-06, Molecular mechanism of prolactin gene regulation in fish, Research Grant Council Earmarked Grant Funding, HKD $780,000, CUHK4410/04M. Results ranked as SATISFACTORY by RGC.
• 2006-07, Regulation of metallothionein gene expression in zebrafish, HKD $ 60,000, MD2041180.
• 2010-11, Molecular mechanism of copper ion intoxication- identification of copper-affected proteins relating to copper ion intoxication in tilapia and zebrafish, HKD $ 60,000, 2030425.
• 2014-15, Elucidating copper sensitivity of zebrafish by studying gene expression of copper transporters in vitro, HKD $ 60,000, 4053040.
• 2015-16, Toxic effects of brominated compounds on zebrafish, HKD 50,000, 3132779.
• 2016-17, Micro-Module Courseware Development Grant: Field Venture- Mobile Electronic Work Sheet for Field Study, HKD $91,000, 3210743. 

 Professional Activities

• American Fisheries Society, member since 1997
• Marine Biological Association of Hong Kong (Standing Committee member, 98-01), member since 1984
• Hong Kong Professional Teachers’ Union (Standing Committee member, 00-04; Secretary, 04- 06)
• Society of Environmental Toxicology and Chemistry (USA), full member 1989 - 2000
• Society of Toxicology (USA), full member since 1992 until now
• The American Physiological Society, full member 2007 - 2010
• Editorial Board Member: Bulletin of Environmental Contamination and Toxicology (since 2013)
• Editorial Board Member: Marine Environmental Research (since 2015)

Others

• 2004/05/06, Part-time member (appointed), Central Policy Unit, HKSAR Government
• 2005-Present, Advisor, Green Community
• 2005-2007, Member (elected in from a by-election), Higher Education Sub-Committee, Election Committee, HKSAR Government
• 2007-2011, Member (elected), Higher Education Sub-Committee, Election Committee, HKSAR Government (Resigned, December 2009)
• 2012-2017, Member (elected), Higher Education Sub-sector, Election Committee, HKSAR Government
• 2009-2019, Member (elected representative from Faculty of Science), Board of Trustees of Shaw College
• 2012-2014, Chairman (elected), Teachers’ Association of The Chinese University of Hong Kong (CUTA)
• 2014-2015, Secretary (elected), Teachers' Association of The Chinese University of Hong Kong (CUTA)
• 2015-17, President (elected), Teachers' Association of The Chinese University of Hong Kong (CUTA)