iGEM 2014 Giant Jamboree: Hong Kong-CUHK Team
A genetic engineering team formed by 10 undergraduate students of science and engineering at The Chinese University of Hong Kong (CUHK) has won a gold medal at the iGEM (international Genetic Engineered Machine) 2014 Giant Jamboree at Boston, USA. This year, the iGEM foundation celebrated its 10th anniversary at Boston Hynes Convention Centre with 243 teams with close to 3000 participants joining this Championship competition from around the world. There were 79 teams achieved gold medal standard in the competition (http://igem.org/Results?year=2014).
The winning project of the CUHK team was named ABCDE: AzotoBacter vinelandii Cluster-transformable & Deoxygenated protein Expression system. The innovative idea of using Azotobacter vinelandii D.J. strain to express recombinant protein under anaerobic condition. The ultimate goal of this project is to manipulate an enzyme called nitrogenase, which could capture carbon dioxide to produce methane gas energy after genetic modifications by adding hydrogenase into its genome by genomic recombination. However, this biosynthetic ABCDE system can do a lot more than just producing energy, this novel system can express any protein or enzyme for industrial applications and has potential use in soil or sewage under anaerobic condition with ammonia for bioremediation purposes. Photos and more details of our team and project information could be found at this website: http://www.sls.cuhk.edu.hk/index.php/undergraduate-programmes/msbbs-article-2/dream-program-2/igem-2014. (This project is partly supported by a Teaching Development Grant, 2012-15).
About iGEM Competition
iGEM is an annual premier synthetic biology competition worldwide for high school, undergraduate and postgraduate students. It was established by the MIT in 2004 to foster students' learning in synthetic biology, promote collaboration among students and nurture biology talents. Participating teams are required to specify, design, build, and test simple biological systems made from standard, interchangeable biological parts. The accomplishments of these student teams often lead to important advances or provide solutions to tackle problems in medicine, food and nutrition, energy, and the environment. For more information, please visit http://www.igem.org.
Prof. CHAN King-ming (School of Life Sciences; 3943-4420)
中大隊伍今年參賽項目主題為 ”固氮菌集束轉型蛋白缺氧表達系統(ABCDE)”。今年中大同學的硏究開發項目，開展了利用固氮細菌在缺氧下表達蛋白質生產，長遠更可利用這改造過的集束基因轉移系統來操控固氮酶的表達，或加入了氫酶，更可以吸收二氧化碳來生產甲烷氣體能源。當然，這生物合成系統更有其工業應用價值，亦可以應用在泥土或者污水中缺氧情況下利用氨氣表達蛋白質，作生物修復工程之用。可以在以下網址找到中大隊伍的更多資訊及圖片: http://www.sls.cuhk.edu.hk/index.php/undergraduate-programmes/msbbs-article-2/dream-program-2/igem-2014. (此項目部分資助由教學發展基金,2012-15,贊助。)