Professor XU Chunliang

Address

(Office): Rm 609, Mong Man Wai Building, CUHK
(Lab): Rm 610, Mong Man Wai Building, CUHK

     People Chunliang Xu 

Phone

(Office): (852) 3943 1298
(Lab): (852) 3943 8034

 
Fax (852) 2603 7732  
Email This email address is being protected from spambots. You need JavaScript enabled to view it.  
Web    
 

 

 


Education

  • 2003-2007  Shandong University
  • 2007-2013  Chinese Academy of Sciences

Positions

  • 2013-2014   Columbia University, Research Fellow
  • 2014-2018   Albert Einstein College of Medicine, Postdoctoral Fellow
  • 2019-2021   Albert Einstein College of Medicine, Research Associate

Research Interests

  • Gut microbiota
  • Hematopoietic stem cells
  • Stem cell niche
  • Psychological stress
  • Neuroimmunology
  • Aging

 Representative Publications

(Full list of publications can be found at https://scholar.google.com/citations?user=LtBS2X0AAAAJ&hl=en )

  1. Wei Q, Pinho S, Dong S, Pierce H, Xu C, Li H, Nakahara F, Boulais PE, Zhang D, Xu J, Maryanovich M, Cuervo AM and Frenette PS. MAEA is an E3 ubiquitin ligase promoting autophagy and self-renewal of haematopoietic stem cells. Nature Communications volume 12, Article number: 2522 (2021)
  2. Xu C, Gulinello M, Frenette PS. Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage. Journal of Experimental Medicine, 2021. 218 (1): e20200065. (Highlighted by Science Translational Medicine: A spicy solution for sickle cell disease.)
  3. Gao X, Zhang D*, Xu C*, Li H, Caron KM, Frenette PS.  Nociceptive nerves regulate haematopoietic stem cell mobilization. 2021 Jan;589(7843):591-596. Nature. (*Equal contribution).
  4. Xu C, Lee SK, D Zhang, Frenette PS. The gut microbiome regulates psychological stress-induced inflammation. Immunity,2020 Aug 18;53(2):417-428.e4. (Highlighted by Nature: Gut microbes and stress team up to make a painful disease worse.) (Preview in Immunity: Gut Feelings Block the Flow: Microbiota Links Stress to Vascular Disease)
  5. Wei Q, Nakahara F, Asada N, Zhang D, Gao Xin, Xu C, Alfieri A, Brodin NP, Zimmerman SE, Mar JC, Guha C, Guo W, and Frenette PS. Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Developmental Cell. 2020 Jun 8;53(5):503-513.e5.
  6. Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka A, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma'ayan A, Greally J, Frenette PS. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells. Nature Cell Biology. 2019 May;21(5):560-567.
  7. Xu C, Frenette PS. Seasonal manifestations of sickle cell disease. Nature Medicine. 2019 Apr;25(4):536-537.
  8. Xu C, Gao X, Wei Q, Nakahara F, Zimmerman SE, Mar J, Frenette PS. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nature Communications. 2018 Jun;9(1):2449.
  9. Gao X, Xu C, Asada N, Frenette PS. The hematopoietic stem cell niche: from embryo to adult. Development. 2018 Jan;145(2).
  10. Zhang D*, Xu C*, Manwani D*, Frenette PS. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016 Feb;127(7):801-9. (* equal contribution).
  11. Zheng C, Yang Q, Xu C, Shou P, Cao J, Jiang M, Chen Q, Cao Q, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y, Wang Y. CD11b Regulates obesity-induced insulin resistance via limiting alternative Activation and proliferation of adipose tissue macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec;112(52):E7239-48.
  12. Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith J, Burk R, Kunisaki Y, Jang J, Scheiermann C, Merad M, Frenette PS. Neutrophil ageing is regulated by the microbiome. Nature. 2015 Sep;525(7570):528-32.
  13. Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y. IFNα-secreting MSCs exerts potent anti-tumor effect in vivo. Oncogene. 2014 Oct;33(42):5047-52.
  14. Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. Transforming growth factor β promotes immune responses in the presence of mesenchymal stem cells. The Journal of Immunology. 2014 Jan;192(1):103-9. (Highlighted in the “In This Issue” section)
  15. Xu C, Ren G, Cao G, Chen Q and Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. The Journal of Biological Chemistry. 2013 Apr;288(16):11074-9.
  16. Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 2012 Dec;11(6):812-24.

Awards

  • 2019   ASH Abstract Achievement Award
  • 2014   Di Ao Scholarship, Di Ao Group and Chinese Academy of Sciences, China
  • 2012   China National Scholarship, Chinese Academy of Sciences, China

Professional Activities

  1. Guest editor for Frontiers in Cell and Developmental Biology
  2. Ad-hoc reviewer for Cancer Letters, Journal of Cellular Physiology, Molecular and Cellular Biochemistry, Stem Cell Research, Stem Cells and Development, Inflammation, Journal of Cellular Biochemistry.

Others

We are always eager to add energetic and passionate researchers (postdocs, graduate students, undergraduates, and research assistants) to our team! If you are interested in joining the lab, please send your CV to Dr. Chunliang Xu (This email address is being protected from spambots. You need JavaScript enabled to view it.).