Education

Positions

• Professor, School of Life Sciences
• Head, Chung Chi College

Research Interests

• Novel Photosensitizers for Photodynamic Therapy
• Yeast Pathogenesis and Engineering

Representative Publications

• Zhou Y, Cheung YK, Ma C, Zhao S, Gao D, Lo PC, Fong WP, Wong KS, Ng DKP (2018) Endoplasmic reticulum-localized two-photon-absorbing boron dipyrromethenes as advanced photosensitizers for photodynamic therapy. Journal of Medicinal Chemistry. 61:3952-3961.
• Feng L, Yuen YL, Xu J, Liu X, Chan MY, Wang K, Fong WP, Cheung WT, Lee SS (2017) Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). Journal of Lipid Research. 58:1114-1131.
• Tsang PW, Fong WP, Samaranayake LP (2017) Candida albicans orf19.3727 encodes phytase activity and is essential for human tissue damage. PLoS One. 12:e0189219.
• Yeung HY, Lo PC, Ng DKP, Fong WP (2017) Anti-tumor immunity of BAM-SiPc-mediated vascular photodynamic therapy in a BALB/c mouse model. Cellular and Molecular Immunology. 14:223-234.
• Choi PW, Yang J, Ng SK, Feltmate C, Muto MG, Hasselblatt K, Lafferty-Whyte K, JeBailey L, MacConaill L, Welch WR, Fong WP, Berkowitz RS, Ng SW (2016) Loss of E-cadherin disrupts ovarian epithelial inclusion cyst formation and collective cell movement in ovarian cancer cells. Oncotarget. 7:4110-4121.
• Fong WP, Yeung HY, Lo PC, Ng DKP (2014) Photodynamic therapy. In Ho AH, Kim D, Somekh MG (ed) Handbook of photonics for biomedical engineering. Springer Netherlands.1-20.
• Rodriguez N, Yang J, Hasselblatt K, Zhou Y, Rauh-Hain J, Ng SK, Choi PW, Fong WP, Agar N, Welch W, Berkowitz R, Ng SW (2012) Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of ovarian cancer cells. EMBO Molecular Medicine. 4:952-963.
• Tang WK, Wong KB, Lam YM, Cha SS, Cheng CH, Fong WP (2008) The crystal structure of seabream antiquitin reveals the structural basis of its substrate specificity. FEBS Letters. 582:3090-3096.
• Leung SCH, Lo PC, Ng DKP, Liu WK, Fung KP, Fong WP (2008) Photodynamic activity of BAM-SiPc, an unsymmetrical bisamino silicon(IV) phthalocyanine, in tumour-bearing nude mice. British Journal of Pharmacology. 154:4-12.
• Fong WP, Cheng CHK, Tang WK (2006) Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions. Cellular and Molecular Life Sciences. 63:2881-2885.

Research Grants

• 2018-2020, RGC Earmarked Grant, Immunogenic Cell Death in the Anti-tumor Photodynamic Action of BAM-SiPc, a Silicon(IV) Phthalocyanine Derivative, $1,034,382
• 2007-2011, RGC Earmarked Grant, Crystal Structure and Biological Activities of Human Antiquitin: Mutation and Functional Analyses, $942,677
• 2005-2008, RGC Earmarked Grant, Development of Novel Phthalocyanine-based Photosensitizers for Photodynamic Therapy: From Chemical Synthesis to in vitro and in vivo Anti-cancer Effects, $718,957
• 2003-2006, RGC Earmarked Grant, Molecular and Functional Studies of Antiquitin from Fish, $1,153,000