Professor GE Wei

Address

(Office): Rm E109, Science Centre East Block

(Lab): LG106/108, Run Run Shaw Science Building (RRSSB)

 People GW

Phone

(Office): (852) 3943 6145

(Lab): (852) 3943 1144
Fax (852) 2603 5646
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.bio.cuhk.edu.hk/bio/teaching_staff/ge_ts.htm
 

 

Education

1993 Ph.D. University of Alberta 
1985 M.Sc. Academia Sinica
1982 B.Sc. Nanjing University

Position

  • Professor, School of Life Sciences
  • Director, Cell and Molecular Biology Programme

Research Interests

  • Reproductive biology and endocrinology
  • Paracrine regulation in fish reproductive axis
  • Molecular biology of gonadotropins and their receptors
  • Impact of endocrine disrupting chemicals on fish reproduction and their action mechanisms

Representative Publications

 

  • Zhou R, Tsang AHK, Lau S-W and Ge W. 2011 Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) and Its Receptors in the Zebrafish Ovary – Evidence for Potential Dual Roles of PACAP in Controlling Final Oocyte Maturation. Biology of Reproduction(in press).
  • Yao K and Ge W. 2010 Kit system in the zebrafish ovary - Evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligands (kitlga and kitlgb) during folliculogenesis. Biology of Reproduction82:1216-1226.
  • Liu L and Ge W. 2007 Growth differentiation factor 9 and its spatiotemporal expression and regulation in the zebrafish ovary. Biology of Reproduction76:294-302.
  • Kwok, H.-F., So, W.-K., Wang, Y. and Ge W. 2005 Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors (Fshr and Lhr) - Evidence for their distinct functions in follicle development. Biology of Reproduction72:1370-81.
  • So W-K, Kwok H-F and Ge W. 2005 Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunits - Their spatial-temporal expression patterns and receptor specificity. Biology of Reproduction72:1382-96.
  • Wang Y and Ge W. 2004 Developmental profiles of activin βA, βB and follistatin expression in the zebrafish ovary - evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction71:2056-2064.
  • Wang Y and Ge W. 2004 Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction71:749-760.
  • Wang Y, Wong AOL and Ge W. 2003 Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology144:4799-4810.
  • Wang Y and Ge W. 2003 Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin bA and bB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144:491-499.
  • Pang Y and Ge W. 2002 Epidermal growth factor (EGF) and transforming growth factor-a (TGF-a) promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Endocrinology143:47-54.

Research Grants

  • 2009, RGC/GRF A zebrafish story on inhibin, an important reproductive hormone that has been largely ignored in lower vertebrates – Does it serve as an ovarian signal to trigger the brain-pituitary axis for oocyte maturation and ovulation? $1,246,502.
  • 2009, Area of Excellence: Centre for Marine Environmental Research and Innovative Technology Action mechanisms of endocrine disrupting chemicals in fish reproductive axis. $1,000,000.
  • 2008, RGC/GRF Proteomic Analysis of Zebrafish Folliculogenesis Identifies Y-Box Binding Protein 1 (YB-1) in the Primary Growth Follicles – Does YB-1 Play a Gate-keeping Role in Ovarian Follicle Recruitment? $1,292,447.
  • 2008, Focused Investment Scheme C Functional analysis of the brain-pituitary-ovarian axis in the zebrafish and its applications. $1,000,000.
  • 2007, RGC/GRF Functional analysis of pituitary-ovarian axis in the zebrafish – Role of EGFR in LHR signaling in the ovary, a continual story of the intraovarian EGF/EGFR network. $689,996.
  • 2006, RGC/GRF Functional analysis of pituitary-gonadal axis in the zebrafish – Role of growth hormone (GH) in the ovary as both endocrine hormone and paracrine growth factor. $1,203,784.
  • 2005, RGC/GRF Functional analysis of pituitary-gonadal axis in the zebrafish – Why do fish need two gonadotropins, and what is the physiological relevance of FSH? $1,397,914.
  • 2004, RGC/GRF Intrafollicular Communication in the Zebrafish Ovary – Roles of GDF-9 from the oocyte in orchestrating follicle development. $1,321,920.
  • 2002, RGC/GRF Epidermal growth factor (EGF) in the ovary of zebrafish – How is it related to the ovarian activin system in controlling oocyte development? $876,000.
  • 2001, RGC/GRF Activin System in the Pituitary: How Important Is It in the Differential Expression of Fish FSH and LH? $699,600.
  • 1999, RGC/GRF Transcriptional Regulation of Gonadotropin-I and II (GTH-I and II) Genes in the Goldfish by Activin – Functional Analysis of cis-acting Elements that Mediate Activin Stimulation of GTH-Ib and Inhibition of GTH-IIb Expression in the Goldfish, Carassius auratus. $789,000.
  • 1996, RGC/GRF Activin Regulation of Pituitary Gonadotropin Gene Expression and Oocyte Development in Goldfish, Carassius auratus. $865,000.

Awards

  • 2007 The VC’s Exemplary Teaching Award, CUHK
  • 2003 The VC’s Exemplary Teaching Award, CUHK
  • 2007 Exemplary Teaching Award, Faculty of Science, CUHK
  • 2003 Exemplary Teaching Award, Faculty of Science, CUHK
  • 2001 Exemplary Teaching Award, Faculty of Science, CUHK
  • 1996 Biology Society Best Lecturer Award, Department of Biology, CUHK

Professional Activities

  • Associate editor, Frontiers in Experimental Endocrinology
  • Member, The Endocrine Society
  • Member, Society for the Study of Reproduction (SSR)
  • Member, American Association for the Advancement of Science (AAAS)
  • Member, Hong Kong Society of Developmental Biology
  • The Council of the International Federation of Comparative Endocrinological Societies (IFCES) (2009-2013)
  • International Program Committee (IPC) for the 17th International Congress of Comparative Endocrinology (ICCE) (Barcelona, Spain, 2013)
  • International Committee for International Symposium on Fish Endocrinology (ISFE) (2008-)
  • International Advisory Board for the 9th International Symposium on Reproductive Physiology of Fish (ISRPF) (Cochin, India, August 2011)
  • International Advisory Board for the 8th International Symposium on Reproductive Physiology of Fish (ISRPF) (St Malo, France, 3-8 June 2007)
  • International Advisory Board for the 7th International Symposium on Reproductive Physiology of Fish (ISRPF) (Mie, Japan, 18-23 May 2003)