Professor ZHUANG Xiaohong

Address

(Office): Rm 181, Science Centre (South), CUHK
(Lab): Rm LG105, Run Run Shaw Science Building, CUHK

People ZXH

Phone

(Office): (852) 3943 4066
(Lab): (852) 3943 8963

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web https://sites.google.com/view/zhuang-lab/home
   

Education

2004-2008    BSc, Sun Yat-sen University
2008-2013 MPhil-PhD, The Chinese University of Hong Kong     

Position

  • Assistant Professor, School of Life Sciences, CUHK

Research Interests

  • Autophagy and autophagosome formation in plants and green algae
  • Signalling mechanisms of selective autophagy in plant stress resistance
  • Lipid metabolism and membrane dynamics

Representative Publications (*Corresponding author, #Co-first author)

  1. Sun S, Feng L, Chung KP, Lee KM, Cheung HHY, Luo M, Ren K, Law KC, Jiang L, Wong KB, Zhuang X. * (2021) Mechanistic insights into an atypical interaction between ATG8 and SH3P2 in Arabidopsis thaliana. Autophagy DOI: 1080/15548627.2021.1976965
  2. Ren K, Feng L, Sun S and Zhuang X. * (2021) Plant Mitophagy in Comparison to Mammals: What Is Still Missing? International Journal of Molecular Sciences 2021, 22, 1236.
  3. Zhang, X., Man, Y., Zhuang, X., Shen, J., Zhang, Y., Cui, Y., Yu, M., Xing, J., Wang, G., Lian, N., Hu, Z., Ma, L., Shen, W., Yang, S., Xu, H., Bian, J., Jing, Y., Li, X., Li, R., Mao, T., Jiao, Y., Sodmergen, Ren, H., and Lin, J. (2021). Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques. Sci China Life Sci 64, 1392-1422.
  4. Yang C., Luo M , Zhuang X,  Li F and Gao C. (2020). Transcriptional and Epigenetic Regulation of Autophagy in Plants. Trends in Genetics 36: 676-688.
  5. Wun CL, Quan Y and Zhuang, X. * (2020) Recent Advances in Membrane Shaping for Plant Autophagosome Biogenesis. Frontier in Plant Sciences 11: 565.
  6. Luo M and Zhuang X.* (2018) Selective degradation of Peroxisome by autophagy in plants: mechanisms, functions, and perspectives. Plant Science 274:485-491
  7. Zhuang, X. *, Chung, K.P. #, Luo Mengqian and Jiang, L*. (2018) Autophagosome Biogenesis and the Endoplasmic Reticulum: A plant perspective. Trends in Plant Science 23:677-692
  8. Zhuang, X. #, Chung, K.P. #, Cui, Y. #, Lin, W., Gao, C., Kang, Y.B., and Jiang, L. (2017) ATG9 Regulates Autophagosome Progression from the Endoplasmic Reticulum in Arabidopsis. Proc Natl Acad Sci U S A  114: E426-E43
  9. Soto-Burgos J.#, Zhuang X. #, Jiang L and Bassham C.D (2017) Dynamics of autophagosome formation. Plant Physiology 176:219-229
  10. Gao C.#, Zhuang X. #, Shen J and Jiang L. (2017) Plant ESCRT complexes: moving beyond endosomal sorting. Trends in Plant Science. 22:986-998
  11. Gao C. #, Zhuang X. #, Cui Y., Fu X., He Y., Zhao Q., Zeng Y., Shen J., Luo M., and Jiang L. (2015). Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proc Natl Acad Sci U S A 112, 1886-1891.
  12. Zhuang X. #, Cui, Y. #, Gao, C., and Jiang, L. (2015). Endocytic and autophagic pathways crosstalk in plants. Current Opinion in Plant Biology 28, 39-47.
  13. Cai, Y.#, Zhuang X. #, Gao, C. #, Wang, X. #, and Jiang, L. (2014). The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development. Plant Physiology 165, 1328-1343
  14. Li, S., Liu, L., Zhuang X., Yu, Y., Liu, X., Cui, X., Ji, L., Pan, Z., Cao, X., Mo, B., Zhang, F., Raikhel, N., Jiang, L., and Chen, X. (2013). MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.
  15. Zhuang X. #, Wang, H. #, Lam, S.K., Gao, C., Wang, X., Cai, Y., and Jiang, L. (2013). A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis. Plant Cell 25, 4596-4615.

Research grants

  • 2021-2024, The National Natural Science Foundation of China (NSFC)/Research Grants Council (RGC) of Hong Kong Joint Research Scheme (JRS), Molecular Mechanism Study of the Reciprocal Regulation of SnRK1 Kinase and Plant Autophagy, PI
  • 2021-2023,  Research Grants Council Early Career Scheme (ECS), Molecular mechanism of SH3P2 in plant autophagy and mitochondrial pathway, PI
  • 2018-2021,  Research Grants Council Germany/Hong Kong Joint Research Scheme, Intersection Points of Autophagy and Ubiquitination, PI
  • 2021-2024, Research Grants Council Collaborative Research Fund (CRF), Vacuole Biogenesis, Dynamics and Functions in Plants, co-PI
  • 2020-2023, Research Grants Council Collaborative Research Fund (CRF), The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron, Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong, co-PI
  • 2019-2024, Research Grants Council Research Impact Fund (RIF), Plant Bioreactor for Pharmaceutical Proteins, co-PI

Awards

  • 2018: Higher Education Outstanding Scientific Research Output Awards 2017 2ed Class Prize (Natural Sciences, 3/7), Ministry of Education,China
  • 2015: The Chinese University of Hong Kong Postdoc fellowship, The Chinese University of Hong Kong
  • 2013: The Chinese University of Hong Kong Young Scholars Thesis Awards, The Chinese University of Hong Kong
  • 2013: Postgraduate Student Publication Award, Division of Life Sciences, The Chinese University of Hong Kong

Professional Activities

  • Review editor, Frontiers in Plant Science (Plant Cell Biology), Plant Science, Bio-protocol and Protoplasma, BioMed Research International
  • Assistant features editor, The Plant Cell