Address	(Office): Rm 503B, Mong Man Wai Building, CUHK (Lab): Rm 505, Mong Man Wai Building, CUHK
Phone	(Office): (852) 3943 5021 (Lab): - (852) 3943 5018
Fax	(852) 2603 6382
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	https://www.cuhk.edu.hk/lifesciences/jackwonglab

Education

Position

• Associate Professor, School of Life Sciences, CUHK
• Director of Biotechnology, Entrepreneurship and Healthcare Management Programme

Research Interests

• Vascular and metabolic biology
• Stem cell biology
• Cardiovascular regeneration

Representative Publications

Full Publication List

(ORCID: 0000-0002-4514-3780;  Publons ID: Q-4512-2018)

1. Chen FM, Tse JK, Jin L, Chook CYB, Leung FP, Tse G, Woo CW, Xu A, Chawla A, Tian XY, Chan TF, Wong WT^# (2022). Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration. Theranostics. 2022 Jan 1;12(3):1161-1172. doi: 10.7150/thno.67515. PMID: 35154480; PMCID: PMC8771554.^#Corresponding author
2. Tian Q, Leung FP, Chen FM, Tian XY, Chen ZY, Tse G, Ma S, Wong WT^# (2021). Butyrate protects endothelial function through PPARd/miR-181b signaling. Pharmacol Res. 169:105681. doi: 10.1016/j.phrs.2021.105681 ^#Corresponding author
3. Chook CYB, Chen FM, Tse G, Leung FP, Wong WT^# (2021). Crocodile blood supplementation protects vascular function in diabetic mice. Food Production, Processing and Nutrition. 3:19. doi: 10.3389/fcvm.2021.671666  ^#Corresponding author
4. Tse G, Lee S, Zhou J, Liu T, Wong ICK, Mak C, Mok NS, Jeevaratnam K, Zhang Q, Cheng SH, Wong WT^# (2021). Territory-Wide Chinese Cohort of Long QT Syndrome: Random Survival Forest and Cox Analyses. Front Cardiovasc Med. 5:608592. doi: 10.3389/fcvm.2021.620539 ^#Corresponding author
5. Tse G, Lee S, Liu T, Yuen HC, Wong ICK, Mak C, Mok NS, Wong WT^# (2020). Identification of Novel SCN5A Single Nucleotide Variants in Brugada Syndrome: A Territory-Wide Study From Hong Kong. Front Physiol. 11:574590. doi: 10.3389/fphys.2020.574590 ^#Corresponding author
6. Chen MZ, Tse G, Wong WT^# (2021). Interleukin-4 increases phagocytosis of necrotic cells by macrophages through scavenger receptor CD36. Clin Exp Pharmacol Physiol. 48(1):129-136. doi: 10.1111/1440-1681.13399 #Corresponding author
7. Kho J, Tian XY, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH (2018). Argininosuccinate lyase deficiency causes an endothelial-dependent form of hypertension. Am J Hum Genet. 103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008
8. Tse G, Liu T, Li G, Keung W, Yeo JM, Chan YW, Yan B, Chan YS, Wong SH, Li RA, Zhao J, Wu KK, Wong WT^# (2017). Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts. Oncotarget. 8:85341-85352. doi: 10.18632/oncotarget.19675 ^#Corresponding author
9. Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP (2017). Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. eLife. 2017; 6. doi: 10.7554/eLife.23588
10. Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y, Wong WT^# (2016). E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. 2016 Mar 9;6:22910. doi: 10.1038/srep22910  ^#Corresponding Author
    
    

Research Grants

• 2023-2025, Hong Kong Research Grants Council (RGC), Endothelial leptin resistance exacerbates vascular dysfunction through attenuating PD-L1 expression, Project Number: 14105022, HKD$ $1,180,218 (PI)

• 2021-2023, Hong Kong Research Grants Council (RGC), Type 2 Innate Signals Regulate Immune Populations Conducive for Neonatal Heart Regeneration, Project Number: 14101119, $920,344 (PI)

• 2018-2020, Hong Kong Research Grants Council (RGC) Early Career Scheme (ECS), PPARδ activation attenuates endothelial inflammation by up-regulating miR-181b, Project number: 24163117, HKD$1,263,098 (PI)

• 2017-2018, National Natural Science Foundation of China (NSFC)/ Research Grants Council (RGC) Joint Research Scheme (Conference Grant), Cardiovascular calcium signaling pathway: Role in health and disease, Project number: N_CUHK453/17, HKD$250,000 (PI)

• 2013-2017, American Heart Association (AHA) Scientist Development Grant, Novel Determinants of Differentiation to Endothelial Lineage, USD$308,000 (PI)

• 2014-2015, Kostas Research Center for Cardiovascular Nanomedicine, Targeted Delivery of miRNAs by Nanoparticles as a Novel Therapeutic Strategy in the Treatment of Vulnerable and Unstable Plaque, USD$100,000 (PI)

• 2013-2014, NIH/NHLBI Progenitor Cell Biology Consortium PCBC Jump Start Award, Heterokaryon as a Model for Identifying Novel Determinants of Endothelial Lineage, USD$7,000 (PI)

• 2012-2013, American Heart Association (AHA) Postdoctoral Research Fellowship, Identification of Novel Determinants Towards Endothelial Differentiation Using a Heterokaryon Approach, USD$90,000 (PI)

Awards

Professional Activities