Address	(Office): Rm 503B, Mong Man Wai Building, CUHK (Lab): Rm 505, Mong Man Wai Building, CUHK
Phone	(Office): (852) 3943 5021 (Lab): - (852) 3943 5018
Fax	(852) 2603 6382
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	http://www.cuhk.edu.hk/lifesciences/jackwonglab

Education

Position

• Assistant Professor, School of Life Sciences, CUHK

Research Interests

• Vascular and metabolic biology
• Stem cell biology
• Cardiovascular regeneration

Representative Publications

1. Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y, Wong WT (2016). E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Sci Rep. 9;6:22910.
2. Sayed N, *Wong WT, Ospino F, Meng S, Lee J, Jha A, Dexheimer P, Aronow B, Cooke JP (2015). Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity. Circulation. 131(3):300-9. *Co-first author.
3. Cooke JP, Sayed N, Lee J, Wong WT (2014). Innate immunity and epigenetic plasticity in cellular reprogramming. Current Opinion in Genetics & Development. 28:89-91.
4. Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP (2012). Endothelial cells derived from nuclear reprogramming. Circ Res. 111(10):1363-75.
5. Tian XY, *Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y (2012). PPARδ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93. *Co-first author.
6. Tian XY, *Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y (2012). Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice. Circ Res. 110(9):1211-6. *Co-first author.
7. Tian XY, *Wong WT^#, Wang YX, Leung FP, Ng CF, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y (2012). ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2a cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats. Antioxid Redox Signal. 16(4):363-73. #Co-corresponding author.
8. Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y (2011). Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab. 6;14(1):104-15.
9. Wong WT^#, *Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circ Res. 107(8):984-91. #Co-corresponding author
10. Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y (2010). Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice. Antioxid Redox Signal. 13(6):757-68.

Research Grants

• 2018-2020, Hong Kong Research Grants Council (RGC) Early Career Scheme (ECS), PPARδ activation attenuates endothelial inflammation by up-regulating miR-181b, Project number: 24163117, HKD$1,263,098 (PI)

• 2017-2018, National Natural Science Foundation of China (NSFC)/ Research Grants Council (RGC) Joint Research Scheme (Conference Grant), Cardiovascular calcium signaling pathway: Role in health and disease, Project number: N_CUHK453/17, HKD$250,000 (PI)

• 2013-2017, American Heart Association (AHA) Scientist Development Grant, Novel Determinants of Differentiation to Endothelial Lineage, USD$308,000 (PI)

• 2014-2015, Kostas Research Center for Cardiovascular Nanomedicine, Targeted Delivery of miRNAs by Nanoparticles as a Novel Therapeutic Strategy in the Treatment of Vulnerable and Unstable Plaque, USD$100,000 (PI)

• 2013-2014, NIH/NHLBI Progenitor Cell Biology Consortium PCBC Jump Start Award, Heterokaryon as a Model for Identifying Novel Determinants of Endothelial Lineage, USD$7,000 (PI)
  
  
• 2012-2013, American Heart Association (AHA) Postdoctoral Research Fellowship, Identification of Novel Determinants Towards Endothelial Differentiation Using a Heterokaryon Approach, USD$90,000 (PI)

Awards

Professional Activities