Professor KONG Siu Kai


(Office): Rm 609, Mong Man Wai Building
(Lab): Rm 610, Mong Man Wai Building

People KSK


(Office): (852) 3943 6799
(Lab): (852) 3943 8034

Fax (852) 2603 5123
Email This email address is being protected from spambots. You need JavaScript enabled to view it.



1996 MBA, University of Strathclyde
1989 PhD, The Chinese University of Hong Kong
1986 MSc, University of Salford
1984 SrDip HonDip, Hong Kong Baptist College


  • Emeritus Professor, School of Life Sciences
  • Adjunct Professor, School of Life Sciences

Research Interests

  • Development of Biosensors
  • Erythropoiesis and Apoptosis
  • Mitochondria as regulators of cell death
  • Cancer Biochemistry 

Representative Publications 

  • He H, Ong RCY, Chan KT, Ho HP, and Kong SK (2010) Practical considerations in acquiring biological signals from confocal microscope, published in Techniques in Confocal Microscopy. Academic Press, Chapter 2, pg.21-26.
  • Lau IP, Ngan EK, Loo JF, Suen YK, Ho HP, Kong SK (2010) Aptamer-based bio-barcode assay for the detection of cytochrome-c released from apoptotic cells. Biochem Biophys Res Commun,395:560-564.
  • Ng SP, Wu CM, Wu SY, Ho HP, Kong SK (2010) Differential spectral phase interferometry for wide dynamic range surface plasmon resonance biosensing. Biosens Bioelectron.26:1593-8.
  • He H, Chan KT, and Kong SK (2010) Role of nuclear tubule on the apoptosis of HeLa cells induced by femtosecond laser. Appl Phys Lett, 96:223701-3. (Highlighted by Virtual Journal of Biological Physics Research 2010 June 15; also highlighted by Virtual Journal of Ultrafast Science, 2010, July.)
  • He H, Chan KT, Kong SK, Lee RKY (2008) All-optical human cell fusion by a fiber femtosecond laser. Appl Phys Lett, 93:163901-3 (Highlighted by ‘Femtosecond Fusion’ Nature Photonics 2008, 2:709).
  • Lui JC, Kong SK (2007) Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis. FEBS Lett,581, 109-117.
  • Ho HP, Law WC, Wu SY, Lin Chinlon and Kong SK (2005) Real-time optical biosensor based on differential phase measurement of surface plasmon resonance. Biosenors Bioelectronics,20:2177-80.
  • Suen YK, Fung KP, Choy YM, Lee CY, Chan CW, Kong SK (2000) Concanavalin A induced apoptosis in murine macrophage PU5-1.8 cells through clustering of mitochondria and release of cytochrome c. Apoptosis, 5:369-77.
  • Lui PPY, Kong SK, Fung KP, Lee CY (1998) The rise of nuclear and cytosolic Ca2+ can be uncoupled in HeLa cells. Pflügers Arch (Eur J Physiol),436, 371-6.
  • Kong SK et al (1996) Concanavalin A induced apoptosis in murine macrophages through Ca2+-independent pathway. Cell Death Different, 3:307-14.

Research Grants

  • 011-2012, GRF, To develop an aptamer-based surface plasmon resonance biosensor to detect apoptosis for anticancer drug discovery, HKD 855,437.
  • 2010-2012, HHSRF, A mechanistic study of Scutellaria baicalensis Georgi(Huangqin) and rosiglitazone coadministration on the treatment of type 2 diabetes mellitus. HKD 988,728.
  • 2010-2011, GRF, High precision and high efficiency laser induced cell-cell fusion assisted by nanorods. HKD 642,400.
  • 2010-2011, GRF, The oncogenic pathway of riboregulator H19: From microRNA to DNA methylation. HKD 1,100,000.
  • 2010-2011, Funding from the CUHK Research Committee Group Research Scheme, Functional plasmonics for biosensing applications. HKD 500,000.
  • 2009-2011, GRF, To develop a novel surface plasmon resonance biosensor for real-time DNA amplification and detection, HKD 488,109.
  • 2009-2011, GRF, Suppression of caspase 3 by a novel non-coding RNA CUDR: A miRNA Perspective. HKD 1,080,520.
  • 2009-2010, GRF, Femtosecond-laser-induced transfection of living cells with foreign DNA. HKD 462,219.
  • 2008-2011, QEF, The development of student-Oriented Teaching and Learning resources in Science and a Science Enrichment Programme for Secondary 3-4 students. HKD 3,500,000.
  • 2008-2011, GRF, Integrated wide dynamic range photonic biosensors and label-free DNA detection using surface-plasmon enhanced magneto-optical phase change. HKD 769,790.
  • 2008-2010, GRF, A novel regulator of insulin release by HMG CoA reductase inhibitors (statins) in porcine isolated pancreatic islets beta-cells. HKD 1,085,729.
  • 2008, UGC Special Equipment Grant, Acquisition of fluorescence lifetime imaging (FLIM) system, HKD 4,098,173.
  • 2008, ITF (Tier 3), Phase-sensitive surface plasmon resonance biosensors for healthcare applications. HK$ 999,350.
  • 2008-2010, GRF, Femtosecond-laser-induced fusion of living cells with liposomes for the delivery of foreign DNA. HKD 462,219.
  • 2008-2010, GRF, Integrated wide dynamic range photonic biosensors and label-free DNA detection using surface-plasmon-enhanced magneto-optical phase change. HKD 769,790.
  • 2007-2009, GRF, Electro-optically tunable surface plasmon resonance biosensor micro-arrays. HKD 557,700.
  • 2006-2010, Funding from The Hong Kong Jockey Club Charities Trust - CE Community, To set up food composition database for nutrition labeling. HKD 17,770,000.
  • 2006-2008, RGC Earmarked Grants, Phase imaging of surface plasmon resonance and sensor surface engineering for multi-analyte biosensor chips. HKD 448,000.
  • 2006-2008, RGC Earmarked Grants, Regulation of therapeutics induced apoptosis in human cancer cells by an apoptotic factor on chromosome 1q. HKD 884,957.
  • 2006-2008, Funding from Shun Hing Institute of Advanced Engineering, Photonic biosensor microarrays diagnostics applications. HKD 724,000.
  • 2006-2008, QEF, A science enrichment programme for secondary 3-4 students. HKD 2,000,000.
  • 2004-2006, QEF, Case-based learning of high school science subjects to support learning to learn. HKD 2,820,000.
  • 2005-2006, RGC Earmarked Grants, Riboregulator modulation of drug resistance in human cancer cells. HKD 939,968.
  • 2003-2005, RGC Earmarked Grants, Bioassay-guided isolation, characterization, and mechanistic study of the bioactive components from Paeonia lactiflora, Sophora flavescens, Oldenlandia diffusa and Scutellaria barata for the anti-proliferative effect on human hepatoma cells in vitro and in vivo. HKD 716,000.
  • 2003-2004, Funding from Greater China Technology Group Limited, Study of immunomodulatory activities of Herbsnsenses TM Cordyceps in healthy subjects: A randomized double-blind placebo-controlled cross-over study. HKD 1,118,000.
  • 2003-2005, RGC Earmarked Grants, Establishment of a SARS coronavirus protein/peptide library and an antibody library as common platforms for biological and medical applications. HKD 800,000.
  • 2002-2005, Shanghai/Hong Kong/Anson Research Foundation,, Mechanistic study of anti-tumour effect of natural and synthetic saponins. HKD 1,325,000.
  • 2001-2003, RGC Earmarked Grants, Functional analysis of a novel gene over-expressed in doxorubicin resistant human cancer cells. HKD 699,600.
  • 1994-1996, RGC Earmarked Grants, Signal transduction in normal macrophages & macrophage cell lines. HKD 1,291,000.
  • 1992-1994, RGC Earmarked Grants, Signal transduction in PU5-1.8 cells & normal macrophages. HKD 372,000. [This project was externally assessed and ranked “EXCELLENT” by the RGC panel.]


  • Optical Sensing Devices with SPR Sensors Based on Differential Phase Interrogation and Measuring Method Using the Same. Filing Country/City: US, Preliminary US Class Code / Class Code: 356, Patent No.7365855 B2, Date of Patent: 29 April 2008. 

  • Surface Plasmon Resonance Sensors and Methods for Detecting Samples Using the Same. Filing Country/City: US, Preliminary US Class Code / Class Code: 435, Patent No./ Application No.: 11/337,034, Filing Date: 19/Jan/2006. 

  • Method and Apparatus for Phase Sensitive Surface Plasmon Resonance, U.S. Provisional Patent Pending (03/2008).

Professional Activities

  • Chartered Biologist, MSB, Society of Biology (UK)
  • Member, Society of Chinese Bioscientists in America
  • Member, Hong Kong Society of Molecular Biology & Biochemistry


  • Hong Kong-CUHK 2010 iGEM team member