Professor KONG Siu Kai

Address

(Office): Rm 609, Mong Man Wai Building
(Lab): Rm 610, Mong Man Wai Building

People KSK

Phone

(Office): (852) 3943 6799
(Lab): (852) 3943 8034

Fax (852) 2603 5123
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.bch.cuhk.edu.hk/skkong
 

 

Education

1996 MBA, University of Strathclyde
1989 PhD, The Chinese University of Hong Kong
1986 MSc, University of Salford
1984 SrDip HonDip, Hong Kong Baptist College

Position

  • Professor, School of Life Sciences

Research Interests

  • Development of Biosensors
  • Erythropoiesis and Apoptosis
  • Mitochondria as regulators of cell death
  • Cancer Biochemistry 

Representative Publications 

  • He H, Ong RCY, Chan KT, Ho HP, and Kong SK (2010) Practical considerations in acquiring biological signals from confocal microscope, published in Techniques in Confocal Microscopy. Academic Press, Chapter 2, pg.21-26.
  • Lau IP, Ngan EK, Loo JF, Suen YK, Ho HP, Kong SK (2010) Aptamer-based bio-barcode assay for the detection of cytochrome-c released from apoptotic cells. Biochem Biophys Res Commun,395:560-564.
  • Ng SP, Wu CM, Wu SY, Ho HP, Kong SK (2010) Differential spectral phase interferometry for wide dynamic range surface plasmon resonance biosensing. Biosens Bioelectron.26:1593-8.
  • He H, Chan KT, and Kong SK (2010) Role of nuclear tubule on the apoptosis of HeLa cells induced by femtosecond laser. Appl Phys Lett, 96:223701-3. (Highlighted by Virtual Journal of Biological Physics Research 2010 June 15; also highlighted by Virtual Journal of Ultrafast Science, 2010, July.)
  • He H, Chan KT, Kong SK, Lee RKY (2008) All-optical human cell fusion by a fiber femtosecond laser. Appl Phys Lett, 93:163901-3 (Highlighted by ‘Femtosecond Fusion’ Nature Photonics 2008, 2:709).
  • Lui JC, Kong SK (2007) Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis. FEBS Lett,581, 109-117.
  • Ho HP, Law WC, Wu SY, Lin Chinlon and Kong SK (2005) Real-time optical biosensor based on differential phase measurement of surface plasmon resonance. Biosenors Bioelectronics,20:2177-80.
  • Suen YK, Fung KP, Choy YM, Lee CY, Chan CW, Kong SK (2000) Concanavalin A induced apoptosis in murine macrophage PU5-1.8 cells through clustering of mitochondria and release of cytochrome c. Apoptosis, 5:369-77.
  • Lui PPY, Kong SK, Fung KP, Lee CY (1998) The rise of nuclear and cytosolic Ca2+ can be uncoupled in HeLa cells. Pflügers Arch (Eur J Physiol),436, 371-6.
  • Kong SK et al (1996) Concanavalin A induced apoptosis in murine macrophages through Ca2+-independent pathway. Cell Death Different, 3:307-14.

Research Grants

  • 011-2012, GRF, To develop an aptamer-based surface plasmon resonance biosensor to detect apoptosis for anticancer drug discovery, HKD 855,437.
  • 2010-2012, HHSRF, A mechanistic study of Scutellaria baicalensis Georgi(Huangqin) and rosiglitazone coadministration on the treatment of type 2 diabetes mellitus. HKD 988,728.
  • 2010-2011, GRF, High precision and high efficiency laser induced cell-cell fusion assisted by nanorods. HKD 642,400.
  • 2010-2011, GRF, The oncogenic pathway of riboregulator H19: From microRNA to DNA methylation. HKD 1,100,000.
  • 2010-2011, Funding from the CUHK Research Committee Group Research Scheme, Functional plasmonics for biosensing applications. HKD 500,000.
  • 2009-2011, GRF, To develop a novel surface plasmon resonance biosensor for real-time DNA amplification and detection, HKD 488,109.
  • 2009-2011, GRF, Suppression of caspase 3 by a novel non-coding RNA CUDR: A miRNA Perspective. HKD 1,080,520.
  • 2009-2010, GRF, Femtosecond-laser-induced transfection of living cells with foreign DNA. HKD 462,219.
  • 2008-2011, QEF, The development of student-Oriented Teaching and Learning resources in Science and a Science Enrichment Programme for Secondary 3-4 students. HKD 3,500,000.
  • 2008-2011, GRF, Integrated wide dynamic range photonic biosensors and label-free DNA detection using surface-plasmon enhanced magneto-optical phase change. HKD 769,790.
  • 2008-2010, GRF, A novel regulator of insulin release by HMG CoA reductase inhibitors (statins) in porcine isolated pancreatic islets beta-cells. HKD 1,085,729.
  • 2008, UGC Special Equipment Grant, Acquisition of fluorescence lifetime imaging (FLIM) system, HKD 4,098,173.
  • 2008, ITF (Tier 3), Phase-sensitive surface plasmon resonance biosensors for healthcare applications. HK$ 999,350.
  • 2008-2010, GRF, Femtosecond-laser-induced fusion of living cells with liposomes for the delivery of foreign DNA. HKD 462,219.
  • 2008-2010, GRF, Integrated wide dynamic range photonic biosensors and label-free DNA detection using surface-plasmon-enhanced magneto-optical phase change. HKD 769,790.
  • 2007-2009, GRF, Electro-optically tunable surface plasmon resonance biosensor micro-arrays. HKD 557,700.
  • 2006-2010, Funding from The Hong Kong Jockey Club Charities Trust - CE Community, To set up food composition database for nutrition labeling. HKD 17,770,000.
  • 2006-2008, RGC Earmarked Grants, Phase imaging of surface plasmon resonance and sensor surface engineering for multi-analyte biosensor chips. HKD 448,000.
  • 2006-2008, RGC Earmarked Grants, Regulation of therapeutics induced apoptosis in human cancer cells by an apoptotic factor on chromosome 1q. HKD 884,957.
  • 2006-2008, Funding from Shun Hing Institute of Advanced Engineering, Photonic biosensor microarrays diagnostics applications. HKD 724,000.
  • 2006-2008, QEF, A science enrichment programme for secondary 3-4 students. HKD 2,000,000.
  • 2004-2006, QEF, Case-based learning of high school science subjects to support learning to learn. HKD 2,820,000.
  • 2005-2006, RGC Earmarked Grants, Riboregulator modulation of drug resistance in human cancer cells. HKD 939,968.
  • 2003-2005, RGC Earmarked Grants, Bioassay-guided isolation, characterization, and mechanistic study of the bioactive components from Paeonia lactiflora, Sophora flavescens, Oldenlandia diffusa and Scutellaria barata for the anti-proliferative effect on human hepatoma cells in vitro and in vivo. HKD 716,000.
  • 2003-2004, Funding from Greater China Technology Group Limited, Study of immunomodulatory activities of Herbsnsenses TM Cordyceps in healthy subjects: A randomized double-blind placebo-controlled cross-over study. HKD 1,118,000.
  • 2003-2005, RGC Earmarked Grants, Establishment of a SARS coronavirus protein/peptide library and an antibody library as common platforms for biological and medical applications. HKD 800,000.
  • 2002-2005, Shanghai/Hong Kong/Anson Research Foundation,, Mechanistic study of anti-tumour effect of natural and synthetic saponins. HKD 1,325,000.
  • 2001-2003, RGC Earmarked Grants, Functional analysis of a novel gene over-expressed in doxorubicin resistant human cancer cells. HKD 699,600.
  • 1994-1996, RGC Earmarked Grants, Signal transduction in normal macrophages & macrophage cell lines. HKD 1,291,000.
  • 1992-1994, RGC Earmarked Grants, Signal transduction in PU5-1.8 cells & normal macrophages. HKD 372,000. [This project was externally assessed and ranked “EXCELLENT” by the RGC panel.]

Patents

  • Optical Sensing Devices with SPR Sensors Based on Differential Phase Interrogation and Measuring Method Using the Same. Filing Country/City: US, Preliminary US Class Code / Class Code: 356, Patent No.7365855 B2, Date of Patent: 29 April 2008. 


  • Surface Plasmon Resonance Sensors and Methods for Detecting Samples Using the Same. Filing Country/City: US, Preliminary US Class Code / Class Code: 435, Patent No./ Application No.: 11/337,034, Filing Date: 19/Jan/2006. 


  • Method and Apparatus for Phase Sensitive Surface Plasmon Resonance, U.S. Provisional Patent Pending (03/2008).

Professional Activities

  • Chartered Biologist, MSB, Society of Biology (UK)
  • Member, Society of Chinese Bioscientists in America
  • Member, Hong Kong Society of Molecular Biology & Biochemistry

Others

  • Hong Kong-CUHK 2010 iGEM team member