Address |
(Office): Room E409, Science Centre East Block |
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Phone |
(Office): (852) 3943 6336 |
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Fax | (852) 3943 6336 | |
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Web | http://137.189.43.137:8080/Publications/HML-publications.htm | |
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Education
1992 | Ph.D. Northwestern University |
1987 | M. Phil. The Chinese University of Hong Kong |
1985 | B. Sc. The Chinese University of Hong Kong |
Position
- Professor, School of Life Sciences, CUHK
- Director, Molecular Biotechnology Program, CUHK
- Director, Center for Soybean Research, CUHK
- Director, State Key Laboratory of Agrobiotechnology (CUHK)
- Director, RGC-AoE Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security (CUHK)
- Associate Director, Institute of Plant Molecular Biology & Agricultural Biotechnology, CUHK
- Student Hostel Warden, Daisy Li Hall, New Asia College, CUHK
Research Interests
- Climate-smart and sustainable agriculture
- Plant and agricultural biotechnology
- Genomic studies on crop-environment interaction
Representative Publications
- M. Xie, C.Y.-L. Chung, M.-W. Li, F.-L. Wong, X. Wang, A. Liu, Z. Wang, A.K.-Y. Leung, T.-H. Wong, S.-W. Tong, Z. Xiao, K. Fan, M.-S. Ng, X. Qi, L. Yang, T. Deng, L. He, L. Chen, A. Fu, Q. Dong, J. He, G. Chung, S. Isobe, T. Tanabata, B. Valliyodan, H.T. Nguyen, S.B. Cannon, C.H. Foyer, T.-F. Chan, H.-M. Lam. 2019. A reference-grade wild soybean genome. Nat. Commun. 10:1216. https://doi.org/10.1038/s41467-019-09142-9
- C. Foyer, H.M. Lam, H. Nguyen, K. Siddique, R. Varshney, T. Colmer, W. Cowling, H. Bramley, T. Mori, J. Hodgson, J. Cooper, T. Miller, K. Kunert, B. Vorster, C. Cullis, J. Ozga, M. Wahlqvist, Y. Liang, H. Shou, K. Shi, J. Yu, N. Fodor, B. Kaiser, F.-L. Wong, B. Valliyodan, M. Considine. 2016. Neglecting legumes has compromised global food and nutritional security. Nat. Plants 2:16112 DOI: 10.1038/NPLANTS.2016.112.
- M.-Y. Cheung, X. Li, R. Miao, Y.-H. Fong, K.-P. Li, Y.-L. Yung, M.-H. Yu, K.-B. Wong, Z. Chen, H.-M. Lam. 2016. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses. Proc. Natl. Acad. Sci. USA DOI:10.1073/pnas.1522966113.
- Y.-L. Yung, M.-Y. Cheung, R. Miao, Y.-H. Fong, K.-P. Li, M.-H. Yu, M.-L. Chye, K.-B. Wong, H.-M. Lam. 2015. Site-directed mutagenesis shows the significance of interactions with phospholipids and the G-protein OsYchF1 on the physiological functions of the rice GTPase-Activating Protein 1 (OsGAP1). J. Biol. Chem. 290:23984-23990.
- X. Qi, M.-W. Li, M. Xie, X. Liu, M. Ni, G. Shao, C. Song, A.K.-Y. Yim, Y. Tao, F.-L. Wong, S. Isobe, C.-F. Wong, K.-S. Wong, C. Xu, C. Li, Y. Wang, R. Guan, F. Sun, G. Fan, Z. Xiao, F. Zhou, T.-H. Phang, X. Liu, S.-W. Tong, T.-F. Chan, S.-M. Yiu, S. Tabata. J. Wang, X. Xu, H.-M. Lam. 2014. Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing. Nat. Commun. 5:4340 DOI: 10.1038/ncomms5340.
- M.-Y. Cheung, M.-W. Li, Y.-L. Yung, C.-Q. Wen, H.-M. Lam. 2013. The unconventional P-loop NTPase OsYchF1 and its regulator OsGAP1 play opposite roles in salinity stress tolerance. Plant Cell Environ. 36: 2008–2020.
- H.-M. Lam, J. Remais, M.-C. Fung, L. Xu, S.S.-M. Sun. 2013. Food supply and food safety issues in China. Lancet 381:2044-2053.
- H. Wang, L. Zhou, Y. Fu, M.-Y. Cheung, F.-L. Wong, T.-H. Phang, Z. Sun and H.-M. Lam. 2012. Expression of an apoplast-localized BURP-domain protein from soybean (GmRD22) enhances tolerance toward abiotic stress. Plant Cell Environ. 35:1932-1947.
- H.-M. Lam, X. Xu, X. Liu, W. Chen, G. Yang, F.-L. Wong, M.-W. Li, W. He, N. Qin, B. Wang, J. Li, M. Jian, J. Wang, G. Shao, J. Wang, S.S.-M. Sun, and G. Zhang. 2010. Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat. Genet. 42:1053-1059.
- M.-Y. Cheung, Y. Xue, L. Zhou, M.-W. Li, S.S.-M. Sun, and H.-M. Lam. 2010. An ancient P-loop GTPase in rice is regulated by a higher plant-specific regulatory protein. J. Biol. Chem. 285:37359–37369.
- L. Zhou, M.-Y. Cheung, Q. Zhang, C.-L. Lei, S.-H. Zhang, S.S.-M. Sun, and H.-M. Lam. 2009. A novel simple extracellular leucine-rich repeat (eLRR) domain protein from rice (OsLRR1) enters the endosomal pathway and interacts with the hypersensitive induced reaction protein 1 (OsHIR1). Plant Cell Environ. 32:1804-1820.
- M.-Y. Cheung, N.-Y. Zeng, S.-W. Tong, F.W.-Y. Li, Y. Xue, K.-J. Zhao, C. Wang, Q. Zhang, Y. Fu, Z. Sun, S.S.-M. Sun, and H.-M. Lam. 2008. Constitutive expression of a rice GTPase activating protein induces defense responses. New Phytol. 179:530-545.
- F.W.-Y. Li, G. Shao, and H.-M. Lam. 2008. Ectopic expression of GmPAP3 alleviates oxidative damage caused by salinity and osmotic stresses. New Phytol. 178:80-91.
- F.W.-Y. Li, F.-L. Wong, S.-N. Tsai, T.-H. Phang, G. Shao, and H.-M. Lam. 2006. Tonoplast located GmCLC1 and GmNHX1 from soybean enhance salt tolerance in transgenic Bright Yellow (BY)-2 cells. Plant Cell Environ. 29:1122-1137.
Research Grants
- 2019-2020, ENSURE, Global Food Security, Climate Change and Resilience: An International Perspective, HK$1,000,000
- 2018-2019, "港澳台科技創新合作" 重點專項 國家重點研發計劃, RMB$980,000
- 2018-2020, GRF, Possible roles of a plant ribosome-associated protein on translational regulation, $1,034,257
- 2017-2025, RGC-AoE, Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security, $81,156,000
- 2017-2019, GRF, Characterization of soybean multidrug and toxin extrusion (MATE) transporters that regulate the accumulation of flavonoid phenolic metabolites in soybean seeds, $1,181,200
- 2016-2018, GRF, Site-directed mutagenesis to delineate the interactions of a plant regulator which loves to interact, $1,306,718
- 2015-2017, GRF, The roles of the soybean Rj2/Rfg1 protein in the interaction with the rhizobial bacterium Sinorhizobium fredii, $878,400
- 2013-2016, GRF, Functional dissection of a novel C2-domain protein that regulates an unconventional G-protein in plants, $1,125,842
- 2012-2015, CRF, Genomic and molecular studies of a salinity tolerance locus in the wild soybean genome, $8,035,050
- 2011-2013, GRF, Using a unique recombinant inbred population and genomic sequencing information to map loci controlling important agronomic traits of soybean, $2,070,000
- 2010-2011, GRF, The functional roles of GmSAL1 in enhancing stress tolerance via regulating the basal cytosolic calcium level, $869,124
- 2009-2010, GRF, The roles of a novel G-protein binding protein in plant defense response, $990,465
- 2004-2007, CERG, Characterization and functional analysis of a novel NaCl-inducible purple acid phosphatase-like gene, $939,968
- 2002-2005, CERG, Gene regulation in the signal transduction pathways of broad-spectrum bacterial blight resistance loci in rice, $876,000
- 2000-2003, CERG, Sink-source relationship during seed development in Arabidopsis thaliana– molecular regulation of aspartate family amino acids, $1,062,600
- 1999-2003, Molecular and biochemical characterization of a salt-tolerant soybean variety, $709,500
- 1998-2002, CERG, Asparagine synthetase genes: their roles in plant growth and development, $1,032,000
- 1997-1999, Ho Sin Hang Education Endowment Fund, Reclaiming the salty lands for agriculture, $250,000
Patents
U.S. Patents (Granted)
- Plant nitrogen regulatory P-PII polypeptides; Patent number: 6,822,079 (2004)
- Plant nitrogen regulatory P-PII genes; Patent number: 6,177,275 (2001)
- Plant glutamate receptors; Patent number: 5,824,867 (1998); 5,981,703 (1999); 5,959,174 (1999); 6,451,546 (2002)
- Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase; (Patent No. 7,939,712B2) (May 10, 2011)
- Abiotic stress tolerance conferred by J domains containing proteins (Patent No. 7,939,711B2) (May 10, 2011)
- Use of GmRD22-like genes to protect against abiotic stress (Patent No. 7,994,390B2) (August 9, 2011)
- Methods to enhance plant trauma resistance (Patent No. 7,994,392B2) (August 9, 2011)
- Methods to improve plant resistance to infections (Patent No. 7,994,393B2) (August 9, 2011)
China Patents (Granted)
- Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same (Patent No. CN1281759C) (Feb 2007)
- Methods to improve plant resistance to infections (Patent No. CN101686646B) (May 23, 2012)
- Gmrd22-like genes and use thereof to protect against abiotic stress (Patent No. CN101548013B) (March 21, 2012)
- Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase (Patent No. CN101541165B) (May 15, 2013)
- Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. CN101553569B) (June 20, 2013)
- Methods to enhance plant trauma resistance (Patent No. CN101686642B) (January 1, 2014)
Hong Kong Patents (Granted)
- Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same; Patent number 1071908 (August 2007)
- Use of GmRD22-like genes to protect against abiotic stress (Patent No. 1137776) (December 2, 2012)
- Methods to improve plant resistance to infections (Patent No. 1140910) (March 1, 2013)
- Method to alleviate abiotic stress in plants (Patent No. HK1132878) (September 19, 2013)
- Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. HK1138033) (March 14, 2014)
Awards
- 2017, Higher Education Outstanding Scientific Research Award 2016 (Science and Technology; Second Class), Ministry of Education of the People's Republic of China
- 2016-2021, Outstanding Fellow of the Faculty of Science
- 2012-2013, Research Excellence Award, The Chinese University of Hong Kong
- 2007, Second-Class Award for Science and Technology, Zhejiang Province, PRC: Establishment and Large Scale Application of an Efficient and Safe System for Transgenic Rice Technology.
- 2001, Second-Class Award for Scientific and Technological Achievements, Beijing City, PRC: Research and Application of Salt Tolerance Study in Soybean
- 1999-2000 &2005-2006, Exemplary Teaching Award Faculty of Science, CUHK
- 1998, Award for Excellence in Presentation, 6th Pacific Rim Biotechnology Conference and BioExpo '98
- 1992, Raymond W. Sarber Award, American Society for Microbiology
Professional Activities
Visiting Professorships
- 2006-present, Visiting Professor (Institute of Plant Sciences, Jilin University, China)
- 2000-present, Visiting Research Professor (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, China)
- 2012-present, Visiting Research Professor (Gansu Academy of Agricultural Sciences, China)
- 2011-present, Visiting Research Professor (Institute of Economic Crops, Shanxi Academy of Agricultural Sciences, China)
Editorial Boards
- 2014-present, PLOS ONE
- 2013-present, Journal of Proteomics and Genomics
- 2013-present, The Crop Journal
- 2010-present, Acta Agronomica Sinica
- 2010-present, Soybean Science
- 2009-present, Botanical Studies
Professional Services
- 2017 – present, Director, State Kay Laboratory of Agrobiotechnology (The Chinese University of Hong Kong)
- 2012 – present, Member of the Academic Committee, State Key Laboratory of Agrobiotechnology, China Agricultural University
- 2018 – present, Member of the Academic Committee, State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A & F University
- 2017 – 2019, Chairperson, Genetically Modified Organisms (Control of Release) Expert Group, Department of Fishery, Agriculture and Conservation, Government of HKSAR
- 2013 – 2019, Member, Genetically Modified Organisms (Control of Release) Expert Group, Department of Fishery, Agriculture and Conservation, Government of HKSAR
- 2012 – present, Director, Center for Soybean Research, The Chinese University of Hong Kong
- 2006 – present, Associate Director, Institute of Plant Molecular Biology and Agricultural Biotechnology at The Chinese University of Hong Kong
Others
Services in Education
- 2016 – 2017, Chair, Assessment Panel on Science Education Key Learning Area, Chief Executive's Award for Teaching Excellence (2016/17)
- 2014 – 2018, Member of the Committee on Certification for Principalship, Education Bureau, Government of HKSAR
- 2013 – 2019, Member of Sub-committee on Initial Teacher Education, COTAP, Education Bureau, Government of HKSAR
- 2013 – 2018, Member of CDC Ad Hoc Committee for the Revision of the Science (S1-3) Curriculum, Education Bureau, Government of HKSAR
- 2003 – 2017, Chairman, Curriculum Development Institute and Hong Kong Examinations and Assessment Authority Joint Committee on Integrated Science (Senior Secondary), Education Bureau, Government of HKSAR
- 2003 – present, Member, Curriculum Development Institute and Hong Kong Examinations and Assessment Authority Joint Committee on Integrated Science (Senior Secondary), Education Bureau, Government of HKSAR