Professor LAM Hon Ming

Address

(Office): Room E409, Science Centre East Block
(Lab): Room 298, Science Centre South Block

 People HML
 

Phone

(Office): (852) 3943 6336
(Lab): (852) 3943 8132
Fax (852) 3943 6336
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://137.189.43.137:8080/Publications/HML-publications.htm
 

 


Education

1992 Ph.D. Northwestern University
1987 M. Phil. The Chinese University of Hong Kong
1985 B. Sc. The Chinese University of Hong Kong


Position

  • Professor, School of Life Sciences, CUHK
  • Director, Molecular Biotechnology Program, CUHK
  • Director, Center for Soybean Research, CUHK
  • Director, State Key Laboratory of Agrobiotechnology (CUHK)
  • Director, RGC-AoE Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security (CUHK)
  • Associate Director, Institute of Plant Molecular Biology & Agricultural Biotechnology, CUHK
  • Student Hostel Warden, Daisy Li Hall, New Asia College, CUHK


Research Interests

  • Climate-smart and sustainable agriculture
  • Plant and agricultural biotechnology
  • Genomic studies on crop-environment interaction 

 
Representative Publications

  • M. Xie, C.Y.-L. Chung, M.-W. Li, F.-L. Wong, X. Wang, A. Liu, Z. Wang, A.K.-Y. Leung, T.-H. Wong, S.-W. Tong, Z. Xiao, K. Fan, M.-S. Ng, X. Qi, L. Yang, T. Deng, L. He, L. Chen, A. Fu, Q. Dong, J. He, G. Chung, S. Isobe, T. Tanabata, B. Valliyodan, H.T. Nguyen, S.B. Cannon, C.H. Foyer, T.-F. Chan, H.-M. Lam.  2019. A reference-grade wild soybean genome. Nat. Commun. 10:1216. https://doi.org/10.1038/s41467-019-09142-9
  • C. Foyer, H.M. Lam, H. Nguyen, K. Siddique, R. Varshney, T. Colmer, W. Cowling, H. Bramley, T. Mori, J. Hodgson, J. Cooper, T. Miller, K. Kunert, B. Vorster, C. Cullis, J. Ozga, M. Wahlqvist, Y. Liang, H. Shou, K. Shi, J. Yu, N. Fodor, B. Kaiser, F.-L. Wong, B. Valliyodan, M. Considine. 2016. Neglecting legumes has compromised global food and nutritional security. Nat. Plants 2:16112 DOI: 10.1038/NPLANTS.2016.112.
  • M.-Y. Cheung, X. Li, R. Miao, Y.-H. Fong, K.-P. Li, Y.-L. Yung, M.-H. Yu, K.-B. Wong, Z. Chen, H.-M. Lam. 2016. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses. Proc. Natl. Acad. Sci. USA  DOI:10.1073/pnas.1522966113.
  • Y.-L. Yung, M.-Y. Cheung, R. Miao, Y.-H. Fong, K.-P. Li, M.-H. Yu, M.-L. Chye, K.-B. Wong, H.-M. Lam. 2015. Site-directed mutagenesis shows the significance of interactions with phospholipids and the G-protein OsYchF1 on the physiological functions of the rice GTPase-Activating Protein 1 (OsGAP1). J. Biol. Chem. 290:23984-23990. 
  • X. Qi, M.-W. Li, M. Xie, X. Liu, M. Ni, G. Shao, C. Song, A.K.-Y. Yim, Y. Tao, F.-L. Wong, S. Isobe, C.-F. Wong, K.-S. Wong, C. Xu, C. Li, Y. Wang, R. Guan, F. Sun, G. Fan, Z. Xiao, F. Zhou, T.-H. Phang, X. Liu, S.-W. Tong, T.-F. Chan, S.-M. Yiu, S. Tabata. J. Wang, X. Xu, H.-M. Lam. 2014. Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing. Nat. Commun. 5:4340 DOI: 10.1038/ncomms5340.
  • M.-Y. Cheung, M.-W. Li, Y.-L. Yung, C.-Q. Wen, H.-M. Lam. 2013. The unconventional P-loop NTPase OsYchF1 and its regulator OsGAP1 play opposite roles in salinity stress tolerance. Plant Cell Environ. 36: 2008–2020.
  • H.-M. Lam, J. Remais, M.-C. Fung, L. Xu, S.S.-M. Sun. 2013. Food supply and food safety issues in China. Lancet 381:2044-2053.
  • H. Wang, L. Zhou, Y. Fu, M.-Y. Cheung, F.-L. Wong, T.-H. Phang, Z. Sun and H.-M. Lam. 2012. Expression of an apoplast-localized BURP-domain protein from soybean (GmRD22) enhances tolerance toward abiotic stress. Plant Cell Environ. 35:1932-1947.
  • H.-M. Lam, X. Xu, X. Liu, W. Chen, G. Yang, F.-L. Wong, M.-W. Li, W. He, N. Qin, B. Wang, J. Li, M. Jian, J. Wang, G. Shao, J. Wang, S.S.-M. Sun, and G. Zhang. 2010. Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat. Genet. 42:1053-1059.
  • M.-Y. Cheung, Y. Xue, L. Zhou, M.-W. Li, S.S.-M. Sun, and H.-M. Lam. 2010. An ancient P-loop GTPase in rice is regulated by a higher plant-specific regulatory protein. J. Biol. Chem. 285:37359–37369.
  • L. Zhou, M.-Y. Cheung, Q. Zhang, C.-L. Lei, S.-H. Zhang, S.S.-M. Sun, and H.-M. Lam. 2009. A novel simple extracellular leucine-rich repeat (eLRR) domain protein from rice (OsLRR1) enters the endosomal pathway and interacts with the hypersensitive induced reaction protein 1 (OsHIR1). Plant Cell Environ. 32:1804-1820.
  • M.-Y. Cheung, N.-Y. Zeng, S.-W. Tong, F.W.-Y. Li, Y. Xue, K.-J. Zhao, C. Wang, Q. Zhang, Y. Fu, Z. Sun, S.S.-M. Sun, and H.-M. Lam. 2008. Constitutive expression of a rice GTPase activating protein induces defense responses. New Phytol. 179:530-545.
  • F.W.-Y. Li, G. Shao, and H.-M. Lam. 2008. Ectopic expression of GmPAP3 alleviates oxidative damage caused by salinity and osmotic stresses. New Phytol. 178:80-91.
  • F.W.-Y. Li, F.-L. Wong, S.-N. Tsai, T.-H. Phang, G. Shao, and H.-M. Lam. 2006. Tonoplast located GmCLC1 and GmNHX1 from soybean enhance salt tolerance in transgenic Bright Yellow (BY)-2 cells. Plant Cell Environ. 29:1122-1137.


Research Grants

  • 2019-2020, ENSURE, Global Food Security, Climate Change and Resilience: An International Perspective, HK$1,000,000
  • 2018-2019, "港澳台科技創新合作" 重點專項 國家重點研發計劃, RMB$980,000
  • 2018-2020, GRF, Possible roles of a plant ribosome-associated protein on translational regulation, $1,034,257
  • 2017-2025, RGC-AoE, Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security, $81,156,000
  • 2017-2019, GRF, Characterization of soybean multidrug and toxin extrusion (MATE) transporters that regulate the accumulation of flavonoid phenolic metabolites in soybean seeds, $1,181,200
  • 2016-2018, GRF, Site-directed mutagenesis to delineate the interactions of a plant regulator which loves to interact, $1,306,718
  • 2015-2017, GRF, The roles of the soybean Rj2/Rfg1 protein in the interaction with the rhizobial bacterium Sinorhizobium fredii, $878,400
  • 2013-2016, GRF, Functional dissection of a novel C2-domain protein that regulates an unconventional G-protein in plants, $1,125,842
  • 2012-2015, CRF, Genomic and molecular studies of a salinity tolerance locus in the wild soybean genome, $8,035,050
  • 2011-2013, GRF, Using a unique recombinant inbred population and genomic sequencing information to map loci controlling important agronomic traits of soybean, $2,070,000
  • 2010-2011, GRF, The functional roles of GmSAL1 in enhancing stress tolerance via regulating the basal cytosolic calcium level, $869,124
  • 2009-2010, GRF, The roles of a novel G-protein binding protein in plant defense response, $990,465
  • 2004-2007, CERG, Characterization and functional analysis of a novel NaCl-inducible purple acid phosphatase-like gene, $939,968
  • 2002-2005, CERG, Gene regulation in the signal transduction pathways of broad-spectrum bacterial blight resistance loci in rice, $876,000
  • 2000-2003, CERG, Sink-source relationship during seed development in Arabidopsis thaliana– molecular regulation of aspartate family amino acids, $1,062,600
  • 1999-2003, Molecular and biochemical characterization of a salt-tolerant soybean variety, $709,500
  • 1998-2002, CERG, Asparagine synthetase genes: their roles in plant growth and development, $1,032,000
  • 1997-1999, Ho Sin Hang Education Endowment Fund, Reclaiming the salty lands for agriculture, $250,000


Patents

U.S. Patents (Granted)

  1. Plant nitrogen regulatory P-PII polypeptides; Patent number: 6,822,079 (2004)
  2. Plant nitrogen regulatory P-PII genes; Patent number: 6,177,275 (2001)
  3. Plant glutamate receptors; Patent number: 5,824,867 (1998); 5,981,703 (1999); 5,959,174 (1999); 6,451,546 (2002)
  4. Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase; (Patent No. 7,939,712B2) (May 10, 2011)
  5. Abiotic stress tolerance conferred by J domains containing proteins (Patent No. 7,939,711B2) (May 10, 2011)
  6. Use of GmRD22-like genes to protect against abiotic stress (Patent No. 7,994,390B2) (August 9, 2011)
  7. Methods to enhance plant trauma resistance (Patent No. 7,994,392B2) (August 9, 2011)
  8. Methods to improve plant resistance to infections (Patent No. 7,994,393B2) (August 9, 2011)

China Patents (Granted)

  1. Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same (Patent No. CN1281759C) (Feb 2007)
  2. Methods to improve plant resistance to infections (Patent No. CN101686646B) (May 23, 2012)
  3. Gmrd22-like genes and use thereof to protect against abiotic stress (Patent No. CN101548013B) (March 21, 2012) 
  4. Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase (Patent No. CN101541165B) (May 15, 2013)
  5. Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. CN101553569B) (June 20, 2013) 
  6. Methods to enhance plant trauma resistance (Patent No. CN101686642B) (January 1, 2014)

Hong Kong Patents (Granted)

  1. Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same; Patent number 1071908 (August 2007)
  2. Use of GmRD22-like genes to protect against abiotic stress (Patent No. 1137776) (December 2, 2012) 
  3. Methods to improve plant resistance to infections (Patent No. 1140910) (March 1, 2013)
  4. Method to alleviate abiotic stress in plants (Patent No. HK1132878) (September 19, 2013) 
  5. Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. HK1138033) (March 14, 2014)

 
Awards

  • 2017, Higher Education Outstanding Scientific Research Award 2016 (Science and Technology; Second Class), Ministry of Education of the People's Republic of China
  • 2016-2021, Outstanding Fellow of the Faculty of Science
  • 2012-2013, Research Excellence Award, The Chinese University of Hong Kong
  • 2007, Second-Class Award for Science and Technology, Zhejiang Province, PRC: Establishment and Large Scale Application of an Efficient and Safe System for Transgenic Rice Technology.
  • 2001, Second-Class Award for Scientific and Technological Achievements, Beijing City, PRC: Research and Application of Salt Tolerance Study in Soybean
  • 1999-2000 &2005-2006, Exemplary Teaching Award Faculty of Science, CUHK
  • 1998, Award for Excellence in Presentation, 6th Pacific Rim Biotechnology Conference and BioExpo '98
  • 1992, Raymond W. Sarber Award, American Society for Microbiology


Professional Activities

Visiting Professorships

  • 2006-present, Visiting Professor (Institute of Plant Sciences, Jilin University, China)
  • 2000-present, Visiting Research Professor (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, China)
  • 2012-present, Visiting Research Professor (Gansu Academy of Agricultural Sciences, China)
  • 2011-present, Visiting Research Professor (Institute of Economic Crops, Shanxi Academy of Agricultural Sciences, China)

Editorial Boards

  • 2014-present, PLOS ONE
  • 2013-present, Journal of Proteomics and Genomics
  • 2013-present, The Crop Journal
  • 2010-present, Acta Agronomica Sinica
  • 2010-present, Soybean Science
  • 2009-present, Botanical Studies

Professional Services

  • 2017 – present, Director, State Kay Laboratory of Agrobiotechnology (The Chinese University of Hong Kong)
  • 2012 – present, Member of the Academic Committee, State Key Laboratory of Agrobiotechnology, China Agricultural University
  • 2018 – present, Member of the Academic Committee, State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A & F University
  • 2017 – 2019, Chairperson, Genetically Modified Organisms (Control of Release) Expert Group, Department of Fishery, Agriculture and Conservation, Government of HKSAR
  • 2013 – 2019, Member, Genetically Modified Organisms (Control of Release) Expert Group, Department of Fishery, Agriculture and Conservation, Government of HKSAR
  • 2012 – present, Director, Center for Soybean Research, The Chinese University of Hong Kong
  • 2006 – present, Associate Director, Institute of Plant Molecular Biology and Agricultural Biotechnology at The Chinese University of Hong Kong


Others

Services in Education

  • 2016 – 2017, Chair, Assessment Panel on Science Education Key Learning Area, Chief Executive's Award for Teaching Excellence (2016/17)
  • 2014 – 2018, Member of the Committee on Certification for Principalship, Education Bureau, Government of HKSAR
  • 2013 – 2019, Member of Sub-committee on Initial Teacher Education, COTAP, Education Bureau, Government of HKSAR
  • 2013 – 2018, Member of CDC Ad Hoc Committee for the Revision of the Science (S1-3) Curriculum, Education Bureau, Government of HKSAR
  • 2003 – 2017, Chairman, Curriculum Development Institute and Hong Kong Examinations and Assessment Authority Joint Committee on Integrated Science (Senior Secondary), Education Bureau, Government of HKSAR
  • 2003 – present, Member, Curriculum Development Institute and Hong Kong Examinations and Assessment Authority Joint Committee on Integrated Science (Senior Secondary), Education Bureau, Government of HKSAR