Faculty and Staff

Professor SHAW Pang Chui

Address

(Office): Rm 180, Science Centre South Block

(Lab): Rm 195, Science Centre South Block

People PCS
 

Phone

(Office): (852) 3943 1363 , 39436803

(Lab): (852) 3943 8027

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.bch.cuhk.edu.hk/pcshaw
 

 

Education

1987 Ph.D. Imperial College, University of London
1983 M.Phil.. The Chinese University of Hong Kong
1981 B.Sc. The Chinese University of Hong Kong

Position

  • Professor, School of Life Sciences
  • Director, Biochemistry Programme
  • Director, Centre for Protein Science and Crystallography
  • Deputy Director, Institute of Chinese Medicine
  • Master, Postgraduate Halls

Research Interests

  • Structure-function studies of proteins
  • Authentication and quality control of Chinese Medicinal material 

Representative Publications

  • Ng, Y.M., Yang, Y.H., Sze, K.H., Zhang, X., Zheng, Y.T. and Shaw, P.C. (2011) Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa cylindrical). J. Str. Biol. 174: 164-172.
  • Li, M., Cao, H., But, P.P.H. and Shaw, P.C. (2011) Identification of herbal medicinal materials using DNA barcodes. J. System. Evol. 49: 271-283.
  • Law, S.K., Simmons, M.P., Techen, N., Khan, I.A., He, M.F., Shaw, P.C. and But, P.P.H. (2011) Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook f.). Phytochemistry 72: 21-26.
  • Su, C., Wong, K.L., But, P.P.H., Su W.W. and Shaw P.C. (2010) Molecular authentication of the Chinese herb Huajuhong and related medicinal material by DNA sequencing and ISSR markers. J. Food Drug Anal. 18: 161-170.
  • Lou S.K., Wong, K.L., Li, M., But, P.P.H. and Shaw, P.C. (2010) An integrated web medicinal materials DNA database: MMDBD (Medicinal materials DNA barcode database). BMC Genomics 11: 402.
  • Law, S.K.Y., Wang, R.R., Mak, A.N.S., Wong, K.B., Zheng, Y.T. and Shaw, P.C. (2010) A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells. Nucl. Acids Res. 38: 6803-6812.
  • Chan, W.H., Ng, A.K., Robb, N.C., Lam, M.K., Chan, P.K., Au, S.W., Wang, J.H., Fodor, E. and Shaw, P.C. (2010) Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol. 84: 7337-7345.
  • Too, P.H.M., Ma, M.K.W., Mak, A.N.S., Wong, Y.T., Tung, C.K.C., Zhu, G., Au, S.W.N., Wong, K.B. and Shaw, P.C. (2009) The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome. Nucl. Acids Res. 37: 602-610.
  • Ng, A.K.L., Zhang, H., Tan, K., Li, Z., Liu, J.H., Chan, P.K.S., Li, S.M., Chan, W.Y., Au, S.W.N., Joachimiak, A., Walz, T., Wang, J. and Shaw, P.C. (2008) Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization and vaccine design. FASEB J. 22: 3638-3647.
  • Mak, A.N.S., Wong, Y.T., An, Y.J., Cha, S.S., Sze, K.H., Au, S.W.N., Wong, K.B. and Shaw, P.C. (2007) Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site. Nucl. Acids Res. 35: 6259-6267.

Research Grants

  • 2011-2012, General Research Fund of Research Grants Council, Structural study and characterization of influenza b virus nucleoprotein, HK$1,111, 612
  • 2011-2013, Research Fund for the Control of Infectious Diseases, Modified maize ribosome-inactivating proteins as possible anti-HIV agent by the SIV-infected rhesus macaque model HK$999,240
  • 2010-2011,中國科學院大科學裝置開放研究項目, 中國涼茶藥用植物的DNA條形碼研究, RMB$100,000
  • 2010-2012, Research Fund for the Control of Infectious Diseases, In silico structure-based screening and characterization of inhibitors for influenza A virus nucleoprotein and RNA polymerase, $996,520
  • 2009-2011, General Research Fund of Research Grants Council, The refinement of the influenza virus H5N1 nucleoprotein structure and the structure-function study of its oligomerization and interaction with RNA, $930,246
  • 2008-2011, The Croucher Foundation, Advanced Study Institute on ‘Structure based screening and design of ligands for protein targets, HK$600,000

Patents

  • But, P.P.H., Xu, Y.T., Shaw, P.C., Jiang, R.W. and Hon, P.M. (2011) Method of making antitussive medicine and relieving cough. US Patent No. 7,867,998.
  • Shaw, P.C., Wang, J., But, P.P.H., Lau, T.W. (2004) The DNA sequences of medicinal Dendrobium and the application of these sequences for species identification and authentication. Chinese Patent ZL 01 1 02434.8.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2003) Application of RFLP of DNA for the authentication of Chinese medicinal material. Chinese patent 98100001.0.
  • Shaw, P.C., Wang, J., But, P.P.H., Ha, W.Y., Yau, F.C.F. (2004) Sequence characterized amplified region (SCAR) test for the authentication of traditional Chinese medicinal materials. US Patent No. 6,803,215.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2001) Polymerase chain reaction-restriction fragment length polymorphism test for the authentication of herbal Chinese medicines. U.S. Patent No. 6,309,840.

Professional Activities

  • Associate Editor, Chinese Medicine
  • Editorial Board, Protein Engineering, Design and Selection
  • Visiting professor, Sun Yat-sen University
  • Vice-chairman, Hong Kong Bioethics Association
  • Council member, Chinese Crystallographic Society, China
  • Council member, Chinese Genetics Society, China