Professor SHAW Pang Chui

Address

(Office): Rm 180, Science Centre South Block
(Lab): Rm 195, Science Centre South Block

People PCS 2 

Phone

(Office): (852) 3943 1363 , 39436803
(Lab): (852) 3943 8027

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://www.bch.cuhk.edu.hk/pcshaw
 

 

Education

1987 Ph.D. Imperial College, University of London
1983 M.Phil.. The Chinese University of Hong Kong
1981 B.Sc. The Chinese University of Hong Kong


Position

  • Professor, School of Life Sciences
  • Director, Biochemistry Programme
  • Director, LDS YYC R & D Centre for Chinese Medicine
  • Deputy Director, Institute of Chinese Medicine
  • Master, Postgraduate Halls
  • Member, CUHK Council

 
Research Interests

  • Structure-function studies of proteins
  • Authentication and quality control of Chinese Medicinal material 


Representative Publications

1.

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease.

Lu JQ, Shou JW, Lo KC, Tang YS, Shi WW, Shaw PC.

Toxins (Basel). 2022 Jun 6;14(6):392. doi: 10.3390/toxins14060392.

PMID: 35737053 Free PMC article.

2.

Comparative Analysis of Chloroplast Genomes of Dalbergia Species for Identification and Phylogenetic Analysis.

Wu HY, Wong KH, Kong BL, Siu TY, But GW, Tsang SS, Lau DT, Shaw PC.

Plants (Basel). 2022 Apr 20;11(9):1109. doi: 10.3390/plants11091109.

PMID: 35567110 Free PMC article.

3.

Chromosomal level genome of Ilex asprella and insight into antiviral triterpenoid pathway.

Kong BL, Nong W, Wong KH, Law ST, So WL, Chan JJ, Zhang J, Lau TD, Hui JH, Shaw PC.

Genomics. 2022 Apr 9;114(3):110366. doi: 10.1016/j.ygeno.2022.110366.

PMID: 35413434

4.

A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein.

Lu JQ, Wong KB, Shaw PC.

Toxins (Basel). 2022 Feb 27;14(3):178. doi: 10.3390/toxins14030178.

PMID: 35324675 Free PMC article. Review.

5.

Strategies for molecular authentication of herbal products: from experimental design to data analysis.

Wu HY, Shaw PC.

Chin Med. 2022 Mar 22;17(1):38. doi: 10.1186/s13020-022-00590-y.

PMID: 35317843 Free PMC article. Review.

6.

Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract.

Xiao M, Lim-Ho Kong B, Zhang Y, Yang Y, Lu J, Lee HK, Cao F, Shaw PC.

J Ethnopharmacol. 2022 Jun 28;292:115175. doi: 10.1016/j.jep.2022.115175. Epub 2022 Mar 16.

PMID: 35306041

7.

Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms.

Shou JW, Shaw PC.

Cells. 2022 Feb 24;11(5):796. doi: 10.3390/cells11050796.

PMID: 35269418 Free PMC article. Review.

8.

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action.

Shou JW, Li XX, Tang YS, Lim-Ho Kong B, Wu HY, Xiao MJ, Cheung CK, Shaw PC.

Free Radic Biol Med. 2022 Mar;181:62-71. doi: 10.1016/j.freeradbiomed.2022.01.022. Epub 2022 Jan 29.

PMID: 35093536

9.

Lyophyllin, a Mushroom Protein from the Peptidase M35 Superfamily Is an RNA N-Glycosidase.

Lu JQ, Shi WW, Xiao MJ, Tang YS, Zheng YT, Shaw PC.

Int J Mol Sci. 2021 Oct 27;22(21):11598. doi: 10.3390/ijms222111598.

PMID: 34769028 Free PMC article.

10.

HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products.

Yik MH, Wong VCT, Wong TH, Shaw PC.

J Tradit Complement Med. 2021 Jul 24;11(6):598-600. doi: 10.1016/j.jtcme.2021.07.005. eCollection 2021 Nov.

PMID: 34765524 Free PMC article. Review.

11.

Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction.

Tang YS, Xu S, Chen YW, Wang JH, Shaw PC.

Nucleic Acids Res. 2021 Apr 19;49(7):4144-4154. doi: 10.1093/nar/gkab203.

PMID: 33784403 Free PMC article.

12.

Comparative analysis and phylogenetic investigation of Hong Kong Ilex chloroplast genomes.

Kong BL, Park HS, Lau TD, Lin Z, Yang TJ, Shaw PC.

Sci Rep. 2021 Mar 4;11(1):5153. doi: 10.1038/s41598-021-84705-9.

PMID: 33664414 Free PMC article.

13.

Assessing the reliability of medicinal Dendrobium sequences in GenBank for botanical species identification.

Wu HY, Chan KT, But GW, Shaw PC.

Sci Rep. 2021 Feb 9;11(1):3439. doi: 10.1038/s41598-021-82385-z.

PMID: 33564041 Free PMC article.

14.

Authentication of Hedyotis products by adaptor ligation-mediated PCR and metabarcoding.

Yik MH, Lo YT, Lin X, Sun W, Chan TF, Shaw PC.

J Pharm Biomed Anal. 2021 Mar 20;196:113920. doi: 10.1016/j.jpba.2021.113920. Epub 2021 Jan 26.

PMID: 33549873

15.

Differentiation of Hedyotis diffusa and Common Adulterants Based on Chloroplast Genome Sequencing and DNA Barcoding Markers.

Yik MH, Kong BL, Siu TY, Lau DT, Cao H, Shaw PC.

Plants (Basel). 2021 Jan 15;10(1):161. doi: 10.3390/plants10010161.

PMID: 33467716 Free PMC article.

16.

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties.

Lu JQ, Zhu ZN, Zheng YT, Shaw PC.

Toxins (Basel). 2020 Mar 9;12(3):167. doi: 10.3390/toxins12030167.

PMID: 32182799 Free PMC article. Review.

17.

Rapid detection of CITES-listed shark fin species by loop-mediated isothermal amplification assay with potential for field use.

But GW, Wu HY, Shao KT, Shaw PC.

Sci Rep. 2020 Mar 10;10(1):4455. doi: 10.1038/s41598-020-61150-8.

PMID: 32157111 Free PMC article.

18.

Anti-influenza virus phytochemicals from Radix Paeoniae Alba and characterization of their neuraminidase inhibitory activities.

Zhang T, Lo CY, Xiao M, Cheng L, Pun Mok CK, Shaw PC.

J Ethnopharmacol. 2020 May 10;253:112671. doi: 10.1016/j.jep.2020.112671. Epub 2020 Feb 17.

PMID: 32081739

19.

Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation.

Shou JW, Cheung CK, Gao J, Shi WW, Shaw PC.

Front Cell Neurosci. 2019 Sep 3;13:395. doi: 10.3389/fncel.2019.00395. eCollection 2019.

PMID: 31551713 Free PMC article.

20.

Application of next-generation sequencing for the identification of herbal products.

Lo YT, Shaw PC.

Biotechnol Adv. 2019 Dec;37(8):107450. doi: 10.1016/j.biotechadv.2019.107450. Epub 2019 Sep 12.

PMID: 31521786 Review.

21.

The Extended C-Terminal Region of Influenza C Virus Nucleoprotein Is Important for Nuclear Import and Ribonucleoprotein Activity.

Tang YS, Lo CY, Mok CK, Chan PK, Shaw PC.

J Virol. 2019 Apr 17;93(9):e02048-18. doi: 10.1128/JVI.02048-18. Print 2019 May 1.

PMID: 30814281 Free PMC article.

22.

A rapid sample-to-answer analytical detection of genetically modified papaya using loop-mediated isothermal amplification assay on lab-on-a-disc for field use.

Loo JF, But GW, Kwok HC, Lau PM, Kong SK, Ho HP, Shaw PC.

Food Chem. 2019 Feb 15;274:822-830. doi: 10.1016/j.foodchem.2018.09.049. Epub 2018 Sep 11.

PMID: 30373016

 
Books

  1. 曹暉、邵鵬柱、畢培曦主編(2016) 中藥分子鑒定 - 技術與應用。694頁。人民衛生出版社。
  1. 邵鵬柱、曹暉主編 (2004)中藥分子鑒定。329頁。復旦大學出版社。
  1. Shaw, P.C., Wang, J. and But, P.P.H. (ed.) (2002) Authentication of Chinese Medicinal Materials by DNA Technology. World Scientific Publishing Co. Ltd. Singapore. (The first international reference in this field of study)


Patents

  • 邵鵬柱, 鄭永唐, 黃錦波, 羅嘉懿, 王睿睿, 麥雅絲.2013. 修飾的玉米核糖體失活蛋白前體及其應用和蛋白純化方法. 中國專利CN102234638.
  • 邵鵬柱,畢培曦,徐宏喜,陳耀文,黃家樂. 2012. 用於鑒定有毒中藥材馬錢子品種的多核苷酸序列及其使用方法.中國專利CN10124537.
  • But, P.P.H., Xu, Y.T., Shaw, P.C., Jiang, R.W. and Hon, P.M. (2011) Method of making antitussive medicine and relieving cough. US Patent No. 7,867,998.
  • Shaw, P.C., Wang, J., But, P.P.H., Lau, T.W. (2004) The DNA sequences of medicinal Dendrobium and the application of these sequences for species identification and authentication. Chinese Patent ZL 01 1 02434.8.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2003) Application of RFLP of DNA for the authentication of Chinese medicinal material. Chinese patent 98100001.0.
  • Shaw, P.C., Wang, J., But, P.P.H., Ha, W.Y., Yau, F.C.F. (2004) Sequence characterized amplified region (SCAR) test for the authentication of traditional Chinese medicinal materials. US Patent No. 6,803,215.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2001) Polymerase chain reaction-restriction fragment length polymorphism test for the authentication of herbal Chinese medicines. U.S. Patent No. 6,309,840.


Research Grants

  1. Evaluation of anti-influenza properties of antrafenine and its analogs (Health and Medical Research Fund, 2019-22, HK$1,499,440)
  2. Molecular authentication of endangered timber samples – protocol development and evaluation on the scope of application (Environment and Conservation Fund, 2019-21, HK$1,290,562)
  3. Screening nickase enzyme candidates for the NGS technology designed by Genvida (Contract Research from Genvida (HK) Co. Ltd, 2019, $375,000)
  4. Isolation and characterization of unique RNA-N glycosidases from mushroom (Research Grants Council, 2018-20, HK$1,229,089)
  5. Development of rapid screening protocol to identify shark fins from endangered species (Environment and Conservation Fund, 2016-18, HK$986,696)
  6. Investigation of the antitussive effects of a folk medicine, cardiocrinum seeds. (Health and Medical Research Fund, 2015-17, $995,128)
  7. Study on the interaction of influenza A virus nucleoprotein and polymerase PB2 N-terminal region (Research Grants Council, 2015-17, $624,538)
  8. Establishment of new paradigm with feasible models in teaching and learning science for problem solving and future development (University Grants Committee, 2014-17, HK$10,000,000, as Co-PI)
  9. Structure-based drug design of anti-influenza compounds targeting influenza polymerase (Health and Medical Research Fund, 2014-16, $998,750)
  10. Preclinical Safety Evaluation and Mechanism Study of Nacre Protein N16:A New First-class Medicine for the Treatment of Osteoporosis (Innovation Technology Commission Fund, 2013-15, $689,955), with additional support of HK$406,993.54 for two additional interns
  11. Interaction study of PinX1 and nucleophosmin and the effect of inhibiting this interaction on tumor growth (Research Grants Council-National Natural Science Foundation of China Joint Research Scheme, 2013-2016, $1,016,658 + 15% on-cost)

 
Professional Activities

  • Editorial Board, Protein Engineering, Design and Selection
  • Co-Editor, Biodesign (Korea)
  • Editorial Board, Toxins (Basel)