Professor CHOW Hei Man Kim

Address

(Office): Rm 604, Mong Man Wai Building, CUHK
(Lab): Rm 612A, Mong Man Wai Building, CUHK

People KimC 

Phone

(Office): (852) 3943 1530
(Lab): (852) 3943 0577

Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web  
 

 


Education

2011    
PhD (Pharmacology and Pharmacy, Medicine), University of Hong Kong
2007
MPhil (Physiology), University of Hong Kong
2005 BSc (Animal and Plant Biotechnology), University of Hong Kong

Positions

  • 2019+         Assistant Professor, School of Life Sciences, CUHK
  • 2015-2019   Junior Fellow, Institute for Advanced Study, HKUST
  • 2015-2019   Research Assistant Professor, Division of Life Science, HKUST
  • 2013-2015   Postdoctoral Fellow, Division of Life Science, HKUST
  • 2010-2011   Postdoctoral Fellow, School of Electrical and Computer Engineering, Cornell University, USA

Research Interests

  • Metabolic plasticity and neurodegenerative disorders
  • Mitochondrial bioenergetics
  • Aging and cellular senescence

 Representative Publications

        After joining CUHK

  1. Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang. Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance. Nature Metabolism 2022 (Accepted) [22nd out of 23 authors, Impact factor2022: 19.865]
  2. Genper Chi-Ngai Wong and Kim Hei-Man Chow (2022) DNA damage response-associated cell cycle re-entry and neuronal senescence in brain aging and Alzheimer’s disease. Journal of Alzheimer’s Disease. 2022 Jul 11. doi: 10.3233/JAD-220203 [Corresponding author, Impact factor2022: 4.16]
  3. Shaohong Issac Peng, Lok I Leong, Jacquelyne Ka-Li Sun, Zhefan Stephen Chen, Hei-Man Chow and Ho Yin Edwin Chan. (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Molecular Therapy-Nucleic Acids. Vol. 29:102-115 [5th out of 6 authors, Impact factor2022: 10.183]
  4. Zaofeng Yang, Meigui Yang, Hei-Man Chow et al., (2021) Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Acta Biomaterialia; S1742-7061(21)00588-2 [3rd out of 6 authors, Impact factor2022: 10.633]
  5. Hei-Man Chow, Jacquelyne Ka-Li Sun et al.,. (2021) Low-density lipoprotein receptor-related protein 6 cell surface availability regulates fuel metabolism in astrocytes. Advanced Science. 2021 Aug;8(16):e2004993 [Corresponding and 1st author, Impact factor2022: 17.521]
  6. Shaohong Peng, Pei Guo, Xiao Lin, Ying An, Kong Hung Sze, Matthew Ho Yan Lau, Zhefan Stephen Chen, Qianwen Wang, Wen Li, Jacquelyne Ka-Li Sun, Sum Yi Ma, Ting-Fung Chan, Kwok-Fai Lau, Jacky Chi Ki Ngo, Kin Ming Kwan, Chun-Ho Wong, Sik Lok Lam, Steven C. Zimmerman, Tiziano Tuccinardi, Zhong Zuo, Ho Yu Au-Yeung, Hei-Man Chow, and Ho Yin Edwin Chan. (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. PNAS. 118(19): e2022940118. [22nd out of 23 authors, Impact factor2022: 12.779] 
  7. Ying Zhang, Zhongyu Zhang, Lianwei Li, Kaiyu Xu, Zhanshan Ma, Hei-Man Chow, Karl Herrup, Jiali Li. (2020) Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease. FASEB J. 34(12):16364-16382. [6th out of 8 authors; Impact factor2022: 5.834]
  8. Aifang Cheng, Kai-Hei Tse, Hei-Man Chow et al., (2021) ATM loss disrupts the autophagy-lysosomal pathway. Autophagy 17(8):1998-2010. [3rd out of 9 authors, Impact factor2022: 13.391]
  9. Jiechao Zhou, Hei-Man Chow et al., (2020) Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry 87(8):756-769. [Co-corresponding and co-1st author, Impact factor2022: 13.437]
  10. Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang, Karl Herrup. (2019) Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Nature Neuroscience. 2(11):1806-1819. [Co-corresponding and 1st author, Highlighted by F1000 Prime as 2 stars article; Impact factor2022: 28.771;]
  11. Murali Doraiswamy, Elisha London, Peter Varnum, Barbara Harvey, Shekhar Saxena, Simon Tottman, Sir Philip Campbell, Alvaro Fernández Ibáñez, Husseini Manji, Mohammad Abdul Aziz Sultan Al Olama, I-han Chou, Helen Herrman, Sung-jin Jeong, Tan Le, Caroline Montojo, Bjarte Reve, Karen S. Rommelfanger, Charlotte Stix, Nitish Thakor, Kim Hei-Man Chow, Andrew E. Welchman, and Vanessa Candeias. (2019) Empowering 8 Billion Minds: Enabling Better Mental Health for All via the Ethical Adoption of Technologies. NAM Perspectives. Policy White Paper, National Academy of Medicine, Washington, DC. [20th out of 22 authors, Impact factor2020: N/A]


    Before joining CUHK (Selected)
  1. Hei-Man Chow, Aifang Cheng et al. (2019) ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. Journal of Cell Biology. 218(3):909-928. [Co-corresponding and 1st author; Journal Spotlight with Commentary, Impact factor2022: 8.077]
  2. Aifang Cheng, Teng Zhao, Kai-Hei Tse, Hei-Man Chow et al. (2018). ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. PNAS. 115(2):E292-E301. [4th out of 9 authors; Impact factor2022: 12.779]
  3. Karl Herrup, Kai-Hei Tse and Hei-Man Chow (2017) Loopholes in the DNA contract kill neurons. Nature Neuroscience.20(9):1192-1194 [Co-corresponding author; Impact factor2020: 28.771]
  4. Jianmin Chen, Yanping Chen, Graham Vail, Hei-Man Chow et al. (2016) The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Molecular Neurodegeneration. 11(1):60 [4th out of 10 authors; Impact factor2022: 18.879]
  5. Hei-Man Chow, Karl Herrup. (2015) Genomic integrity and the ageing brain. Nature Reviews Neuroscience. 16(11):672-84. [1st author; Impact factor2022: 38.775]
  6. Hei-Man Chow, Dong Guo et al. (2014) CDK5 activator protein p25 preferentially binds and activates GSK3β. PNAS. 111(45):E4887-95. [1st author, Impact factor2022: 12.779]
                    

Research Grants

  1. PC, CUHK-Academic Equipment Grant 2021/22/. The Integrated Neuroscience and Metabolic Phenotypic Core (INMPC). HK$3,433,742, 6/03/2022-21/08/2022
  2. PI, Early Career Scheme 2021/22, Chronic alcohol consumption induces brain metabolic reprogramming: implications in accelerated brain aging and potentials of senolytics-based therapies. RGC, HK$ 1,185,691, 01/01/2022-31/12/2024.
  3. PI, Excellent Young Scientists Fund 2020, Metabolic reprogramming mechanism and regulation in cerebellar ataxia. NSFC, CYN$ 1,200,000, 01/01/2021-31/12/2023.
  4. Co-I. Collaborative Research Fund 2019/20, The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong (Project Coordinator: Prof. Liwen JIANG, CUHK). RGC, HK$ 7,439,308, 30/06/2020-29/06/2023.
  5. PI, General Research Fund 2019/20, Loss of nuclear estrogen-related receptor-a (ERRa) activity impairs metabolic plasticity and mitochondrial OXPHOS in neurons: Implications of sex differences observed in Alzheimer’s disease. GRF, HK$ 911,408, 01/01/2020-31/12/2022.
  6. PI, General Research Fund 2018/19, A novel ATM-NRF1 axis facilitates mito-nuclear communication in response to cellular energy demand—Implications for cerebellar neurodegeneration in Ataxia-telangiectasia. GRF, HK$ 972,000, 01/07/2018-31/12/2021.
  7. PI, General Research Fund 2017/18, The Wnt antagonist Dkk1 acts as a bimodal switch of Wnt signaling that controls the neurotrophic versus neurotoxic fates of astrocytes: Implications in the Alzheimer’s disease. GRF, HK$ 819,393, 01/01/2018-31/12/2019.
  8. PI, Alzheimer’s Association Research Fellowship 2017. Targeting brain insulin resistance-mediated neuronal dysfunction in AD. Alzheimer’s Association, US$ 175,000, 01/10/2017-31/09/2021.


Patents

  1. U.S. Provisional Patent Application No. 63/268,153. Title: A metabolic correction approach for treating accelerated brain aging caused by alcohol misuse. Inventor: Hei-Man Chow.
  2. US Patent number US20110098263A1; Title: Hydroxy-Substituted Gold (III) Porphyrin Complexes as Histone Deacetylase Inhibitors; Inventors: CM Che, Yu Wang, Raymond WY Sun; Kim HM Chow.

Awards

  1. CUHK Faculty of Science, Faculty Exemplary Teaching Award 2021 (2022.08)
  2. 2021《JESSICA Most Successful Women Awards
  3. National Natural Science Foundation-Excellent Young Scientist Fund 2020 (優秀青年科學家基金) (2021.01-2023-12)
  4. Young Investigator Award--East Meets West Symposium 2019 on 21st Diabetes & Cardiovascular Risk Factors (2019.09)
  5. L’Oreal-UNESCO-China Association of Science and Technology—2017 For Women in Science: China Future Female Scientist Award (未来女科学家奖) and China-Hong Kong representative for the 2018 L’Oreal-UNESCO International Rising Talents Award
  6. Alzheimer’s Association—Alzheimer’s Association Research Fellowship (2017.10-2021.09)
  7. World Economic Forum—Global Future Council Fellowship (2016.11-2019.11)
  8. HKUST-Institute for Advanced Study (IAS)—Junior Fellowship (2015.09-2019.06)


Professional Activities

Professional Society Committee/Council Member (Honored service):

2019-2022       Society for Neuroscience—Global Membership Committee (GMC)

2017-2019       Society for Neuroscience—Trainee Professional Development Award (TPDA) Selection Committee

2016-2019       World Economic Forum—Global Future Council (GFC), The Future of Neurotechnologies and Brain Science Council

2015-2018       Society for Neuroscience—Trainee Advisory Committee (TAC)

Professional Society Membership

2018+  Alzheimer’s Association (AA)

2013+  Society for Neuroscience (SfN)

2008+  American Association for Cancer Research (AACR)

Research Proposal Review (Selected):

  1. A-T Society Research Grants (UK)
  2. Israel Science Foundation Research Grants (Israel)

Manuscript Review (Selected):

  1. Nature Review Neurology
  2. Science Advances
  3. Alzheimer’s Research & Therapy


Others (Research-related news and Interviews)

  1. Hong Kong Laurate Forum 香港桂冠論壇—Wonder Women in Science: Inspiring and Empowering the Next Generation https://fb.watch/e_GIfiiCYP/ (July 2022)
  2. RTHK 32 凝聚香港-科學界女強人 https://www.youtube.com/watch?v=TXCVt2mfkqM&list=PLuwJy35eAVaIQQ--HY2Q1be3Bbb_Owk8v&index=52 (July 2022)
  3. Our Eminent Scientists @ CUHK —Big Data X Traditional Molecular Biology: Decoding Biological Signalling Network: http://www.sci.cuhk.edu.hk/en-gb/faculty/faces-of-cuhk-science/article/539-20-10-hmchow
  4. L’Oreal HK—Hong Kong woman scientist selected for 2017 Rising Talents in 14th China Young Women in Science Fellowships https://www.loreal.hk/en-hk/media/news/2018/jan/hong-kong-woman-scientist-selected-for-2017-rising-talents
  5. Nature—Career Feature 27 June 2018
    Title: How to build a lab in East Asia’s science hot sports? https://www.nature.com/articles/d41586-018-05513-2?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf192841411=1
  6. Society for Neuroscience—Neuronline—Capital Hill Day March 2018
    Title: If You Get Involved in Science Advocacy, Here’s the Impact You Can Make. https://neuronline.sfn.org/advocacy/if-you-get-involved-in-science-advocacy-heres-the-impact-you-can-make/