Address	(Office): Rm 178, Science Centre South Block (Lab): Rm 193, Science Centre South Block
Phone	(Office): (852) 3943 4170 (Lab): (852) 3943 6118
Fax	(852) 2603 7246
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Education

Position

• Professor, School of Life Sciences

Research Interests

• Protein post-translational modification
• Macromolecular assembly

Representative Publications

• Lam KH, Ip WS, Lam YW, Chan SO, Ling TK, Au SW: Multiple Conformations of FliG C-terminal domain Provide Insight into Flagellar Motor Switching. Structure 2011, (In press)
• Cheng M, Chan SY, Zhao Q, Chan EY, Au SW, Lee SS, Cheung WT: Construction and characterization of single-chain variable fragment antibody library derived from germline rearranged immunoglobulin variable genes.PLoS One 2011, 6:e27406.
• Cheung KK, Yeung SS, Au SW, Lam LS, Dai ZQ, Li YH, Yeung EW: Expression and association of TRPC1 with TRPC3 during skeletal myogenesis.Muscle Nerve 2011, 44:358-65.
• Han Z, Chang YY, Au SW, Zheng B: Measuring rapid kinetics by a potentiometric method in droplet-based microfluidic devices.Chem Commun (Camb) 2011, (In press)
• Wong JH, Legowska A, Rolka K, Ng TB, Hui M, Cho CH, Lam WW, Au SW, Gu OW, Wan DC: Effects of cathelicidin and its fragments on three key enzymes of HIV-1.Peptides 2011, 32:1117-22.
• Kok KH, Lui PY, Ng MH, Siu KL, Au SW, Jin DY: The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe 2011, 9:299-309.
• Lam WL, Woo EJ, Kotaka M, Tam WK, Leung YC, Ling TK, Au SW: Molecular interaction of flagellar export chaperone FliS and co-chaperone HP1076 in Helicobacter pylori. FASEB J 2010, 24:4020-32.
• Lam KH, Ling TK, Au SW: Crystal structure of activated CheY1 from Helicobacter pylori. J Bacteriol 2010,192:2324-34. (Selected for the Journal Highlights section of Microbe)
• Xu Z, Chan HY, Lam WL, Lam KH, Lam LS, Ng TB, Au SW: SUMO proteases: Redox regulation and biological significance. Antioxid Redox Signal 2009, 11:1453-84. (Invited comprehensive review)
• Ng AK, Zhang H, Tan K, Li Z, Liu JH, Chan PK, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC: Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J 2008, 22:3638-47.
• Xu Z, Lam LS, Lam LH, Chau SF, Ng TB, Au SW: Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation. FASEB J 2008,22:127-37.
• Xu Z, Chau SF, Lam KH, Chan HY, Ng TB, Au SW: Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO specific protease. Biochem J 2006,398:345-352. (Selected as a high-quality Chinese science and published in a special issue “Spotlight on China”)
• Xu Z, Au SW: Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. Biochem J 2005, 386:325-330.
• Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D: Doc1/APC10 mediates the E3 ubiquitin ligase activity of the anaphase promoting complex by contributing to APC-substrate recognition. EMBO J 2003, 22: 786-96.
• Au SW, Leng X, Harper JW, Barford D: Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. J Mol Biol 2002, 316:955-68.

Research Grants

• 2010-2013, GRF, Understanding the molecular architecture of motor switch complex in H. pylori, $1,127,158
• 2006-2010, RGC Earmarked Grant, Structural characterization of flagellar export chaperon FliS of Helicobacter pylori, $1,081,750
• 2005-2008 , RGC Earmarked Grant, Proteomic approach for specific identification of SUMO protease substrates, $718,957
• 2004-2007, RGC Earmarked Grant, Structural and functional studies of SUMO E3 ligases and SUMO specific proteases, $1,015,968

Professional Activities

• Secretary, Hong Kong Society of Biochemistry and Molecular Biology
• Member, Biochemical Society
• Member, American Society of Microbiology