Professor KWAN Kin Ming

Address

(Office): Room EG03, Science Center East Block

(Lab): Room G96, Science Center South Block

People KKM
 

Phone

(Office): (852) 3943 1008

(Lab): (852) 3943 6287

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -

 

Education

1997 Ph. D. Department of Biochemistry, The University of Hong Kong, Hong Kong
1990 B. Sc. (Biochemistry), The University of Hong Kong, Hong Kong

Position

  • Associate Professor, School of Life Sciences

Research Interests

 

  • Genetic manipulation by transgenic and gene knockout technology
  • Study of Organogenesis and Tumorigensis using mouse as model organism
  • Neural development and neuronal cell biology
  • Stem cell research

Representative Publications 

  • Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM. (2017) Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun. 8:15079. doi: 10.1038/ncomms15079.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. doi: 10.1038/nature20602.
  • Zhu J, Kwan KM, Mackem S. (2016). Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A. 113(14):3820-3825.
  • Vong KI, Leung CK, Behringer RR, Kwan KM. (2015). Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 8, 25.
  • Tong KK, Kwan KM (2013). Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol. 33(10), 1925-1937.
  • Wong YL, Behringer RR, Kwan KM (2012). Ventral limb ectoderm Smad1/Smad5 signaling functions redundantly and is required in interdigital programmed cell death. Dev Biol. 363(1), 247-257.
  • Tam WY, Leung CK, Tong KK, Kwan KM (2011). Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Neuroscience. 172, 562-571.
  • Zhao Y*, Kwan KM*, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H (2007). LIM-homeodomain proteins Lhx1, Lhx5, and their cofactor Ldb1 control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 104, 13182-13186. * equal contribution as first author
  • Kwan KM. (2002). Conditional alleles in mice: practical considerations for tissue-specific knockouts. Genesis. 32, 49-62.
  • Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP and Cheah KS. (1997). Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol. 136, 459-471.

 

Research Grants

Research Grants Council (RGC) Hong Kong: General Research Fund

  • 2013-2015, Functional analysis of Foxp4 in exocrine pancreas development and homeostasis in mouse - HKD$ 850,000 (as PI)
  • 2011-2013, GRF, Functional analysis of Foxp4 in Purkinje neurons of cerebellum in mice, HKD$ 1,133,900 (as PI)
  • 2010-2012, GRF, Functional analysis of Sox9 in neural progenitor cells of cerebellum in mice, HKD$ 1,195,046 (as PI)
  • 2009-2011, GRF, Functional analysis of Smad genes in granule neurons of cerebellum in mice, HKD$ 1,064,049 (as PI)
  • 2008-2010, GRF, Functional analysis of Lhx1 and Lhx5 in Purkinje neurons of cerebellum in mice, HKD$ 1,146,611 (as PI)


Research Grants Council (RGC) Hong Kong: Collaborative Research Fund

  • 2014-2017, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors - HKD$ 7,044,220 (as Co-I)
  • 2013-2016, Physical Exercise Promotes Vascular Health: Impact of Mechano-Transduction and Novel endothelium-derived Regulators - HKD$ 7,700,000 (as Co-I)
  • 2012-2015, EXPO (Exocyst-positive Organelle): Dynamics, Biogenesis and Function in Plants - HKD$ 8,459,400 (as Co-I)

Research Grants Council (RGC) Hong Kong: Area of Excellence

  • 2014-2020, Center for Organelle Biogenesis and Function - HKD$ 47,250,000 (as Co-I)


Health and Medical Research Fund (HMRF)

  • 2015-2017, Investigation on ataxia disorder by using a novel genetically-modified mouse model - HKD$ 999,880 (as PI)

Awards

2009 and 2013 Science Faculty Exemplary Teaching Award, The Chinese University of Hong Kong
2008 The Young Researcher Award 2008, The Chinese University of Hong Kong
1991-1994 The Croucher Foundation Scholarship, Hong Kong