Professor CHAN Michael Kenneth

Address
(Office): Room 603B, Mong Man Wai Building
(Lab): Room 611, Mong Man Wai Building
People MC
Phone
(Office): (852) 3943 1487
(Lab): (852) 3943 6162
Fax 
(852) 2603 5646 
Email
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Web


Education

B.S. (Chemistry)  Harvey Mudd College, Claremont, CA
Ph.D. (Chemistry)  University of California, Berkeley, CA
Postdoctoral Fellow (Protein Crystallography)     California Institute of Technology, Pasadena, CA 


Positions

  • 1995-2001        Assistant Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2001-2005        Associate Professor of Chemistry & Biochemistry, The Ohio State University, Columbus, OH
  • 2005-2012        Professor of Chemistry/Biochemistry, The Ohio State University, Columbus, OH
  • 2010-2012        Interim-Chair of Biochemistry, The Ohio State University, Columbus, OH
  • 2012-2015        Director, School of Life Sciences, The Chinese University of Hong Kong
  • 2012- Present  Professor, School of Life Sciences, The Chinese University of Hong Kong


Research Interests

  • Chemical Biology -  We are working to capitalize on our discovery of pyrrolysine, the 22nd genetically-encoded amino acid, to engineer proteins with novel structures and properties.
  • Protein crystallography - We wish to use protein crystallography to elucidate the structure function relationships of proteins.
  • Protein Delivery -  We are exploring new technologies to deliver proteins to cells.

 Representative Publications

  1. Yang, Z.,; Zheng, J.; Chan, C.-F.; Wong, I.L.K.; Heater, B.S.; Chow, L.M.C.; Lee, M.M.; Chan; M.K. “Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection”, Biomaterials, 2019,217:119286. doi: 10.1016/j.biomaterials.2019.119286.
  2. Heater, B.S.; Chan, W.S.; Lee, M.M.; Chan, M.K. “Directed evolution of a genetically-encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil”, Biotechnol Biofuels, 2019, 12: 165. doi.org/10.1186/s13068-019-1509-5.
  3. Sun, Q.; Cheng, S.W.; Cheung, K.; Lee, M.M.; Chan, M.K. “Cry protein crystal-immobilized metallothioneins for bioremediation of heavy metals from water”, Crystals, 2019, 9(6), 287.
  4. Heater, B.S.; Lee, M.M.; Chan, M.K. “Direct production of a genetically-encoded immobilized biodiesel catalyst”, Sci Rep, 2018, 8:12783, doi:10.1038/s41598-018-31213-y
  5. Nair, M.N.*, Lee, M.M.*, Bonnegarde-Bernard, A., Wallace, J.A., Dean, D.H., Ostrowski, M.C., Burry, R.W., Boyaka, P.N., Chan, M.K. "Cry protein crystals: a novel platform for protein delivery" PLoS One, 2015, 10, 1-16.
  6. Lee, M.M. *; Fekner,T.*; Lu, J.; Heater, B.S; Behrman, E.J., Zhang, L., Hsu, P-H; Chan, M.K. "Pyrrolysine-Inspired Protein Cyclization", Chembiochem, 2014, 15, 1769-72.
  7. Li, X.*; Fekner, T.*; Ottesen, J.J.; Chan, M.K., “A pyrrolysine analog for site-specific protein ubiquitination”, Angew. Chem., 2009, 48, 9184-7.
  8. Gong, W.*; Hao, B.*; Wei, Z.; Ferguson, D.J. Jr.; Tallant, T.; Krzycki, J.A.; Chan, M.K., “Structure of the CODH component of the barkeri ACDS complex” Proc. Natl. Acad. Sci. USA 2008, 105, 9558-63.
  9. Li, X.; Jayachandran, S.; Nguyen, H.H.-T; Chan, M.K. “Structure of the Nitrosomonas europaea Rh protein” Natl. Acad. Sci. USA 2007, 104, 19279-19284.
  10. Blight, S.K.; Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E. Zhao, G., Kang, P., Green-Church, K.B., Chan, M.K., Krzycki, J.A., “Direct charging of tRNACUA with pyrrolysine in vitro and in vivoNature, 2004, 431, 333-5. (cited in Nature, C&E News)
  11. Hao, B., Gong, W., Ferguson, T.K., James, C.M., Krzycki, J.A., Chan, M.K., “Identification of novel UAG encoded residue: structure of a methanogen methyltransferase” Science, 2002, 296, 1462-1466. (cited in C&E News, Nature, Science, CNN Headline News, Reuters)
  12. Gong, W.* Hao, B., Mansy, S.S., Gonzalez, G. Gilles-Gonzalez, M.A., Chan, M.K., “Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction” Natl. Acad. Sci. USA, 1998, 95, 15177-15182.


Research Grants

  1. 2017-2019, Research Grants Council GRF, "Immobilized lipases for biodiesel conversion"
  2. 2016-2018, Health and Medical Research Fund (Co-I, PI: M.M. Lee), "A novel anti-microbial crystal for the treatment of Helicobacter pylori infection"
  3. 2016-2018, Research Grants Council GRF, "Exploring the Potential of Myoglobin as an Anti-Cancer Agent"
  4. 2015-2017, Health and Medical Research Fund, "Biological Crystal Subunit Vaccines for Mycobacterial diseases"
  5. 2014-2017, Research Grants Council GRF, “Studies of a copper peptide complex that can mediate methane oxidation”
  6. 2013-2015, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 10: “Novel dawadawa therapy for intestinal helminthic infections
  7. 2012-2014, Bill and Melinda Gates Foundation, Grand Challenges Explorations: Round 9: “A new system for dual bacterial/insecticidal crop protection


Awards

Lando-SOHIO Fellowship, University of Minnesota (1984), Sigma Xi (1986), Phi-Lambda Upsilon (1986), Regents Fellowship, University of California (1986), Amoco Foundation Fellowship in Chemistry (1991), NIH Postdoctoral Fellowship (1992-1994), NSF Career Award (2000), Alfred P. Sloan Fellowship (2000), Member, NIH Study Section-BMT (2002-2006), Mr. and Mrs. Sun Chan Award in Organic Chemistry (2002), Visiting Scholar of the National Research Council of the Republic of China (2002), OSU College of Biological Sciences Award for Research and Graduate Education (2004), Visiting Scholar of the National Research Council of the Republic of China (2005, 2011), Japan Society for Promotion of Science Fellowship (2006), OSU Distinguished Scholar Award (2009), S. Y. Chung Visiting Fellow of New Asia College, CUHK (2010), Fellow of the American Association for the Advancement of Science (2011), Cynthia Anne Chan Memorial Lecturer, UC Berkeley (2011), RGC Physical Science Panel (2011, Chair 2012).


Others

We are currently recruiting highly motivated graduate students, research assistants, and postdocs for positions in our laboratory.