Professor TSANG Suk Ying Faye

Address

(Office): Rm 607, Mong Man Wai Building

(Lab): Rm 612B, Mong Man Wai Building

People TSY
 

Phone

(Office): (852) 3943 1020

(Lab): (852) 3943 8071

Fax (852) 2603 7732
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Web -
 

 

Education

2003 Ph.D. Chinese University of Hong Kong
1999 B.Sc. Chinese University of Hong Kong (1st class honor)

Position

  • Associate Professor, School of Life Sciences
  • Investigator, State Key Laboratory in Agrobiotechnology
  • Investigator, Ministry of Education (MOE) Key Laboratories for Regenerative Medicine

Research Interests

1. Embryonic stem cells and their cardiac derivatives:

a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.

b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.

c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.

2. Ion channels and cardiovascular physiology.

3. Adult stem cells and cancer stem cells.

Representative Publications

  • Xu Y, So C, Lam HM, Fung MC, and Tsang SY (2018) Apoptosis reversal promotes cancer stem-like cell formation. Neoplasia. 20:295-303.

  • Zhao R, and Tsang SY (2017) Versatile roles of intracellularly located TRPV1 channel. J Cell Physiol. 232:1957-65.

  • Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2016). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. 203:169-81

  • Lo IC, Chan HC, Qi Z, Ng KL, So C and Tsang SY (2016) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 231:403-13.

  • Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, and Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.

  • Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol.168:3458-72.

  • Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, and Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res.97:520-32.

  • Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)

  • Peng LH, Tsang SY, Tabata Y, Gao JQ (2011) Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration. J Control Release. Epub ahead of print.

  • Lau YT, Wong CK, Luo J, Leung LH, Tsang PF, Bian ZX, and Tsang SY (2011) Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Archiv Eur J Physiol.461(1):191-202.

  • Ng SY, Wong CK, and Tsang SY (2010) Differential expression of genes in atrial and ventricular myocytes: insights into the application of embryonic stem cell-derived cardiomyocytes for future therapies. Am J Physiol Cell Physiol. 299:C1234-12.

  • Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, and Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)

  • Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF and Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation111:11-20.

  • Tsang SY, Lesso H and Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem279:43752-9.

  • Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I and Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension44:1-5.

  • Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M and Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke35:1709-14.


Research Grants

  • 2018-2020, GRF, The role of TRPC7 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes, HKD $ 854,494
  • 2017-2019, GRF, The role of TRPV1 channels in regulating the functions of embryonic stem cell-derived cardiomyocytes, HKD $ 893,792
  • 2014-2016, GRF, The role of Angiotensin II and the underlying mechanisms in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 744,788
  • 2013-2014, RGC Germany/Hong Kong Joint Research Scheme, Role of transient receptor potential (TRP) channels in mediating cardiotrophin-1-induced cardiac differentiation in embryonic stem cells, HKD $ 28,600
  • 2013-2014, GRF, The role of TRPC3 in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 650,000
  • 2012-2013, RGC Germany/Hong Kong Joint Research Scheme, Effects of Inflammatory Cytokines on the Cardiac Differentiation of Embryonic Stem Cells: Role of Reactive Oxygen Species, HKD$ 59,200
  • 2011-2014, GRF, Characterization of PinX1 and a novel truncated form of PinX1: their role in maintaining the characteristics of embryonic stem cells, HK$ 752,321
  • 2007-2011, GRF, Directed differentiation of human embryonic stem cells into cardiac lineage and the molecular mechanisms involved, HK$ 1,136,464
  • 2004-2006, Croucher Foundation, Genetic engineering of human embryonic stem cells to create a self-renewable ex vivo library of “custom-tailored” heart cells for transplantation, US$ 71,728


Awards

  • 2017, The Faculty Exemplary Teaching Award, CUHK

  • 2004-2006, The Croucher Foundation Fellowship

 

Professional Activities

  • Member, International Society for Stem Cell Research (United States)

  • Member, Physiology Society (United Kingdom)

  • Member, Biophysical Society (United States)