Address

(Office): Room EG03, Science Center East Block

(Lab): Room G96, Science Center South Block

 People KKM
 

Phone

(Office): (852) 3943 1008

(Lab): (852) 3943 6287
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1997 Ph. D. Department of Biochemistry, The University of Hong Kong, Hong Kong
1990 B. Sc. (Biochemistry), The University of Hong Kong, Hong Kong


Position

  • Professor, School of Life Sciences


Research Interests

  • Genetic manipulation by transgenic and gene knockout technology
  • Study of Organogenesis and Tumorigensis using mouse as model organism
  • Neural development and neuronal cell biology
  • Stem cell research

Representative Publications 

  • Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM. (2021) SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 118(6):e2009568118. doi: 10.1073/pnas.2009568118.
  • Dong X, Kwan KM. (2020) Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 13(1):104. doi: 10.1186/s13041-020-00643-z
  • Ma TC, Vong KI,Kwan KM. (2020) Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis. Cell Rep. 30(11): 3616-3624.e4. doi: 10.1016/j.celrep.2020.02.089.
  • Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM. (2017) Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun. 8:15079. doi: 10.1038/ncomms15079.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. doi: 10.1038/nature20602.
  • Zhu J, Kwan KM, Mackem S. (2016) Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A. 113(14), 3820-3825.
  • Vong KI, Leung CK, Behringer RR, Kwan KM. (2015). Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 8, 25.
  • Tong KK, Kwan KM (2013). Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol. 33(10), 1925-1937.
  • Wong YL, Behringer RR, Kwan KM (2012). Ventral limb ectoderm Smad1/Smad5 signaling functions redundantly and is required in interdigital programmed cell death. Dev Biol. 363(1), 247-257.
  • Tam WY, Leung CK, Tong KK, Kwan KM (2011). Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Neuroscience. 172, 562-571.
  • Zhao Y*, Kwan KM*, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H (2007). LIM-homeodomain proteins Lhx1, Lhx5, and their cofactor Ldb1 control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 104, 13182-13186. * equal contribution as first author
  • Kwan KM. (2002). Conditional alleles in mice: practical considerations for tissue-specific knockouts. Genesis. 32, 49-62.
  • Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP and Cheah KS. (1997). Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol. 136, 459-471.


Research Grants

Research Grants Council (RGC) Hong Kong: General Research Fund

  • 2019-2021, Functional analysis of Sox9 in choroid plexus development and regulation of cerebrospinal fluid secretion – HKD$ 971,368 (as PI)
  • 2013-2015, Functional analysis of Foxp4 in exocrine pancreas development and homeostasis in mouse - HKD$ 850,000 (as PI)
  • 2011-2013, GRF, Functional analysis of Foxp4 in Purkinje neurons of cerebellum in mice, HKD$ 1,133,900 (as PI)
  • 2010-2012, GRF, Functional analysis of Sox9 in neural progenitor cells of cerebellum in mice, HKD$ 1,195,046 (as PI)
  • 2009-2011, GRF, Functional analysis of Smad genes in granule neurons of cerebellum in mice, HKD$ 1,064,049 (as PI)
  • 2008-2010, GRF, Functional analysis of Lhx1 and Lhx5 in Purkinje neurons of cerebellum in mice, HKD$ 1,146,611 (as PI)


Research Grants Council (RGC) Hong Kong: Collaborative Research Fund

  • 2020-2023, The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong – HKD$ 7,439,308 (as Co-I)
  • 2017-2020, The First Integrated cyco-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong – HKD$ 9,500,000 (as Co-I)
  • 2014-2017, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors - HKD$ 7,044,220 (as Co-I)
  • 2013-2016, Physical Exercise Promotes Vascular Health: Impact of Mechano-Transduction and Novel endothelium-derived Regulators - HKD$ 7,700,000 (as Co-I)
  • 2012-2015, EXPO (Exocyst-positive Organelle): Dynamics, Biogenesis and Function in Plants - HKD$ 8,459,400 (as Co-I)

Research Grants Council (RGC) Hong Kong: Area of Excellence

  • 2014-2020, Center for Organelle Biogenesis and Function - HKD$ 47,250,000 (as Co-I)


Health and Medical Research Fund (HMRF)

  • 2015-2017, Investigation on ataxia disorder by using a novel genetically-modified mouse model - HKD$ 999,880 (as PI)


Awards

  • 2009 and 2013 Science Faculty Exemplary Teaching Award, The Chinese University of Hong Kong
  • 2008 The Young Researcher Award 2008, The Chinese University of Hong Kong
  • 1991-1994 The Croucher Foundation Scholarship, Hong Kong

 

 

 

Address

(Office): Rm 291, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People LKF 

Phone

(Office): (852) 3943 1106
(Lab): (852) 3943 6119
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web
   

Education

1999 Ph.D., Chinese University of Hong Kong
1994 M.Phil., Chinese University of Hong Kong
1992 B.Sc., Hong Kong Baptist University


Position

  • Associate Professor, School of Life Sciences
  • Program Director, MSc Programme in Biochemical and Biomedical Sciences, CUHK


Research Interests

  • Amyloid precursor protein interacting proteins in Alzheimer’s disease and neurodegenerative disorders
  • Amyloid precursor protein and its interacting proteins in neurodevelopment 
  • Protein Kinases in neurodegenerative disorders


Representative Publications

  • Chau DD, Ng LLH, Zhai Y and Lau KF (2023) Amyloid precursor protein and its interacting proteins in neurodevelopment. Biochem Soc Trans 51(4), 1647-1659.
  • Iyaswamy A, Thakur A, Guan X, Fung T, Krishnamoorthi S, Gaurav I, Wang X, Yang Z, Lau KF, Wong M, Zhang K, Lian Q, NG R, Chen HJ and Li M (2023) Fe65 engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathogenesis of Alzheimer’s disease. Signal Transduction and Targeted Therapy 8(1):404.
  • Zhai Y, Leung KT and Lau KF (2023) Regulation of cytohesins by their interactors. Neural Regen Res 18 (10) 2186-2187.
  • Chau DDL, Li W, Chan WWR, Sun JKI, Zhai Y, Chow HM and Lau KF (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signalling. FASEB J. 36, e22594
  • Zhai Y, Chan WWR, Li W and Lau KF (2022) ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth. Open Biol (The Royal Society) 12, 220071.
  • Chan WWR, Li W, Chang RCC, and Lau KF (2020) ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1. FASEB J. 34, 16397-16413.
  • Chan WWR, Chau DLD, Li W and Lau KF (2019) Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1. Bio-protocol 9(23): e3449. DOI: 10.21769/BioProtoc.3449.
  • Chau DDL, Yung KWY, Chan WWL, An Y, Hao Y, Chan HYE, Ngo JCK and Lau KF (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035
  • Chan WW, Li W, Chau D L and Lau KF (2019) An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons. J Vis Exp. (152), e60031, doi:10.3791/60031
  • Li W, Chan, Chan WWR, Ngo JCK and Lau KF (2018) Emerging roles of neural adaptor FE65 in neurite outgrowth. Neural Regen Res. 13, 2085-2086.
  • Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE and Lau KF (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 293, 7674-7688.
  • Lee YS, Chow WNV and Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Scientific Reports 7(1):12456. doi: 10.1038/s41598-017-12334-2.
  • Chiu WY, Koon A, Ngo JCK, Chan HYE and Lau KF (2017) GULP1/CED-6 ameliorates Amyloid-β toxicity in a Drosophila model of Alzheimer's disease. Oncotarget 8, 99274-99283. doi.org/10.18632/oncotarget.20062.
  • Lee CW, Stankowski, JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW and Petrucelli L (2017) The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration 12(1):55. doi: 10.1186/s13024-017-0196-6.
  • Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
  • Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
  • Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
  • Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
  • Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
  • Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
  • Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
  • Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
  • Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
  • Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
  • Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.


Research Grants

  • 2022-2025 Collaborative Research Equipment Grant (Co-PI)
  • 2021-2024 Health and Medical Research Fund (PI)
  • 2020-2023 RGC General Research Fund (Co-I)
  • 2019-2021 RGC General Research Fund (PI)
  • 2016-2018 Health and Medical Research Fund (PI)
  • 2015-2017 Health and Medical Research Fund (Co-I)
  • 2015-2017 RGC General Research Fund (Co-I)
  • 2014-2016 Health and Medical Research Fund (PI)
  • 2013-2015 RGC General Research Fund (PI)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2014 Research Fund for the Control of Infectious Diseases (Co-I)
  • 2012-2014 RGC General Research Fund (Co-I)
  • 2011-2013 RGC General Research Fund (PI)
  • 2007-2010 RGC General Research Fund (PI)
  • 2005-2009 Motor Neurone Disease Association UK

 
Awards

  • Science Faculty Exemplary Teaching Award 2013/2014; 2018/2019
  • Croucher Foundation Fellowship 1999-2001

Professional Activities

  • Associate Editor: Frontiers in Molecular Neuroscience
  • Editorial board member: International Journal of Brain Science; SOJ Biochemistry, International Journal of Neurology Research; American Journal of Psychiatry and Neuroscience

 

Address

(Office): Rm 507C, Mong Man Wai Building
(Lab): Rm 507D, Mong Man Wai Building

 People LLK
 

Phone

(Office): (852) 3943 8137
(Lab): (852) 3943 8072
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

http://www.bch.cuhk.edu.hk/lkleung/
 

 

 

Education

  Ph.D. in Nutritional Science, University of Kentucky
  M.Sc. in Food Science and Human Nutrition, University of Wyoming
  B.Sc. in Food Science, University of Alberta


Position

  • 1999 – present Assistant and Associate Professor, Food and Nutritional Sciences Programme,
    Chinese University of Hong Kong
  • 1995 – 1999 Postdoctoral Fellow, NCI-Frederick and University of Maryland


Research Interests

  •  Food Toxicology 


Representative Publications

(Total 66 journal articles & 8 abstracts)

  1. Li F, Wong TY, Lin S-M, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2014) Co-administrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. Journal of Pharmacology and Experimental Therapeutic (accepted).
  2. Wong TY, Lin S-M, Poon CH, Leung LK. (2014) The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. Chemico-Biological Interactions Sep;221:70-76.
  3. Wang Y, Wong TY, Chan FL, Chen S, Leung LK. (2014) Assessing the effect of food myco-toxins on aromatase by using a cell-based system. Toxicology In Vitro Jun;28(4):640-6.
  4. Wong TY, Li F, Lin S-M, Chan FL, Chen S, Leung LK. (2014) Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. BMC Cancer Jun 12;14:426.
  5. Wang Y, Li L, Wang CC, Leung LK. (2013) Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae. Toxicology 314(1): 148–154.
  6. Tan W, Wong TY, Wang Y, Huang J, Leung LK. (2013) CYP19 Expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Molecular and Cellular Endocrinology 375(1-2):106-112.
  7. Tan W, Huang H, Wang Y, Wong TY, Wang CC, Leung LK. (2013) Bisphenol A differentially activates protein kinase C isoforms in murine placental tissue. Toxicology and Applied Pharmacology 269(2):163-168.
  8. Wang Y, Tan W, Leung LK. (2013) Zeranol upregulates corticotrophin-releasing hormone expression in the placental cell line JEG-3. Toxicology Letters 219(3):218-222.
  9. Li FJ, Chow S, Cheung W-H, Chan FL, Chen S, Leung LK. (2013) The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. Journal of Nutritional Biochemistry Jun;24(6):1112-6.
  10. Poon CH, Wong TY, Wang Y, Tsuchiya Y, Nakajima M, Yokoi T, Leung LK. (2013)The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonizing XRE-binding. British Journal of Nutrition 109:1598-1605.


Research Grants

  • Establishing the Citrus Flavonoid Hesperetin as a Natural Alternative to Aromatase Inhibitor Direct Grants HK$38,742 Apr 30, 2011-Apr 30, 2012
  • Pharmacological properties of the licorice flavonoid isoliquiritigenin RGC Earmarked Grant HK$598,500 Jan 1, 2007-Dec 31, 2008


Professional Activities

Manuscript Reviewer
2003-present
Journal of Nutrition, British Journal of Nutrition, Toxicological Sciences, Toxicology in Vitro, BBA-Molecular Cell Research, Molecular Nutrition and Food Research, Nutrition and Cancer, Cancer Letters, BMC Cancer, Cell Biology and Toxicology, Journal of Pharmacy and Pharmacology, Journal of Agricultural and Food Chemistry, Journal of Food Biochemistry.

Grant Reviewer
2004-5, 2010 Cancer Research UK

 

 

Address

(Office): Rm 607, Mong Man Wai Building

(Lab): Rm 612B, Mong Man Wai Building

 People TSY
 

Phone

(Office): (852) 3943 1020

(Lab): (852) 3943 8071
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

2003 Ph.D. Chinese University of Hong Kong
1999 B.Sc. Chinese University of Hong Kong (1st class honor)

Position

  • Professor, School of Life Sciences
  • Investigator, State Key Laboratory in Agrobiotechnology
  • Investigator, Ministry of Education (MOE) Key Laboratories for Regenerative Medicine
  • Investigator, Institute for Tissue Engineering and Regenerative Medicine (iTERM), CUHK
  • Program Director, Food and Nutritional Sciences Program. CUHK
  • Fellow, Assembly of Fellows, United College, CUHK 
  • Trustee, Board of Trustees, United College, CUHK
  • Warden, Pak Chuen Hall, United College, CUHK 

Research Interests

1. Embryonic stem cells and their cardiac derivatives:

a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.

b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.

c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.

2. Ion channels and cardiovascular physiology.

3. Adult stem cells and cancer stem cells.

Representative Publications

  • Liu X, Zhao R, Ding Q, Yao X, Tsang SY (2021) TRPC7 regulates the electrophysiological functions and structures of embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther. 12(1):262.
  • Zhao R, Liu X, Qi Z, Yao X, Tsang SY (2021) TRPV1 channels regulate the automaticity of embryonic stem cells-derived cardiomyocytes through stimulating the Na+/Ca2+ exchanger current. J Cell Physiol. Online ahead of print.
  • Chan HC, Lau YT, Ding Q, Li CK, Wong CM, Shaw PC, Waye MMY, Tsang SY (2020) PinX1t, a novel PinX1 transcript variant, positively regulates cardiogenesis of embryonic stem cells. J Am Heart Assoc. 9:e010240.  
  • Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL, Tsang SY (2020). Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. 235:6794-6807.
  • Qi Z, Chen M, Song Y, Wang X, Chen ZF, Tsang SY *, and Cai Z* (2019) Acute exposure to Triphenyl Phosphate (TPHP) inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish. J Cell Physiol. 234(11):21235-21248.
  • Wang Y, Qi YX, Qi Z, Tsang SY (2019) TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3/RASA4/MAPK pathway. Cancers. 11:558. 
  • Xu Y, So C, Lam HM, Fung MC, Tsang SY (2018) Apoptosis reversal promotes cancer stem-like cell formation. Neoplasia. 20:295-303.
  • Zhao R, and Tsang SY (2017) Versatile roles of intracellularly located TRPV1 channel. J Cell Physiol. 232:1957-65.
  • Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2016). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. 203:169-81.
  • Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY (2016) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 231:403-13.
  • Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.
  • Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol. 168:3458-72.
  • Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res. 97:520-32.
  • Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)
  • Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)
  • Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111:11-20.
  • Tsang SY, Lesso H, Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem 279:43752-9.
  • Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I, Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44:1-5.
  • Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M, Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35:1709-14.


Research Grants

  • 2021-2023, GRF, Role of TRPA1 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes through mediating mitochondrial biogenesis and/or dynamics, HKD $ 996,285
  • 2018-2020, GRF, The role of TRPC7 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes, HKD $ 854,494
  • 2017-2019, GRF, The role of TRPV1 channels in regulating the functions of embryonic stem cell-derived cardiomyocytes, HKD $ 893,792
  • 2014-2016, GRF, The role of Angiotensin II and the underlying mechanisms in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 744,788
  • 2013-2014, RGC Germany/Hong Kong Joint Research Scheme, Role of transient receptor potential (TRP) channels in mediating cardiotrophin-1-induced cardiac differentiation in embryonic stem cells, HKD $ 28,600
  • 2013-2014, GRF, The role of TRPC3 in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 650,000
  • 2012-2013, RGC Germany/Hong Kong Joint Research Scheme, Effects of Inflammatory Cytokines on the Cardiac Differentiation of Embryonic Stem Cells: Role of Reactive Oxygen Species, HKD$ 59,200
  • 2011-2014, GRF, Characterization of PinX1 and a novel truncated form of PinX1: their role in maintaining the characteristics of embryonic stem cells, HK$ 752,321
  • 2007-2011, GRF, Directed differentiation of human embryonic stem cells into cardiac lineage and the molecular mechanisms involved, HK$ 1,136,464
  • 2004-2006, Croucher Foundation, Genetic engineering of human embryonic stem cells to create a self-renewable ex vivo library of “custom-tailored” heart cells for transplantation, US$ 71,728


Awards

  • 2021, The Faculty Exemplary Teaching Award, CUHK
  • 2017, The Faculty Exemplary Teaching Award, CUHK
  • 2004-2006, The Croucher Foundation Fellowship

 

Professional Activities

 

Activities for Science Promotion

 

 

 

 

 

Address

(Office): Rm 286, Science Centre South Block

(Lab): Rm G92, Science Centre South Block

 People WYS2
 

Phone

(Office): (852) 3943 6389

(Lab): (852) 3943 6121
Fax (852) 2603 5745
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1985 Ph.D. University of California at Davis
1977 M.Phil.. The Chinese University of Hong Kong
1975 B.Sc. The Chinese University of Hong Kong

Position

  • Associate Professor, School of Life Sciences

Research Interests

  • Plant Physiology and Biochemistry
  • Phytochemicals and Nutraceuticals
  • Bioactivities of Natural and Synthetic Compounds

Representative Publications 

  • Fan C, Chen J, Wang Y, Wong YS, Zhang Y, Zheng W, Cao W, Chen T: Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering ROS-mediated DNA damage and inactivation of ERK pathway. Free Radical Biology & Medicine 2013. (in press) (http://dx.doi.org/10.1016/j.freeradbiomed.2013.07.002)
  • Wang YD, Wang X, Wong YS: Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilization with selenite. Food Chemistry 2013, 141(3):2385-2393.
  • Huang Y, He L, Liu W, Fan C, Zheng W, Wong YS, Chen T: Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials 2013, 34(29):7106-7116.
  • Gao S, Chen T, Choi MY, Xue J, Wong YS: Cyanidin reverses cisplatin-induced nephrotoxicity through inhibition of ROS-mediated DNA damage and modulation of ERK and AKT pathways. Cancer Letters 2013, 333(1):36-46.
  • Liu Y, Chen T, Liu J, Wong YS: Identification of fluorescent ruthenium complexes containing imidazole derivatives as a new class of apoptosis inducers by living cell real-time imaging. MedChemComm 2013, 4(5):865-869.
  • Su J, Lai H, Chen J, Li L, Wong YS, Chen T, Li X: Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage. PLOS ONE 2013, 8(5): e63502.
  • Liu C, Liu Z, Li M, Li X, Wong YS, Ngai SM, Zheng W, Zhang Y, Chen T: Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLOS ONE 2013, 8(1): e53945.
  • Wang YD, Wang X, Ngai SM, Wong YS: Comparative proteomics analysis of selenium responses in selenium-enriched rice grains. Journal of Proteome Research 2013, 12:808-820.
  • Luo Y, Chen T, Huang X, Wang Y, Wong YS, Zheng W: Synthesis and anticancer activity of a novel selenadiazole derivative and its interaction with bovine serum albumin. Acta Chimica Sinica 2012, 70(11):1295-1303.
  • Wang Y, Wang X, Wong YS: Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice. Journal of Proteomics 2012, 75(6):1849-1866.
  • Liu W, Li X, Wong YS, Zheng W, Yu Y, Zhang Y, Cao W, Chen T: Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism. ACS Nano 2012, 6(8):6578-6591.
  • Zheng S, Li X, Chen T, Zheng W, Wong YS: PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction.International Journal of Nanomedicine 2012, 7:3939-3949.
  • Li L, Wong YS, Chen T, Fan C, Zheng W: Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers. Dalton Transactions 2012, 41:1138-1141.
  • Luo Y, Li X, Huang X, Wong YS, Chen T, Zhang Y, Zheng W: 1,4-Diselenophene-1,4-diketone triggers caspase-dependent apoptosis in human melanoma A375 cells through induction of mitochondrial dysfunction. Chemical and Pharmaceutical Bulletin 2011, 59:1227-1232.
  • Li Y, Li X, Wong YS, Chen T, Zhang H, Liu C, Zheng W: The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials 2011, 32:9068-9076.
  • Zhang H, Chen T, Jiang J, Wong YS, Yang F, Zheng W: Selenium-containing allophycocyanin purified from selenium-enrich Spirulina platensis attenuates AAPH-induced oxidative stress in human erythrocytes through inhibition of ROS generation. Journal of Agricultural and Food Chemistry 2011, 59:8683-8690.
  • Liu Y, Zhang X, Zhang R, Chen T, Wong YS, Liu J, Zheng WJ: Ruthenium porphyrin complexes induce apoptosis by inhibiting the generation of intracellular reactive oxygen species in the human hepatoma cell line (HepG2).European Journal of Inorganic Chemistry 2011, 2011:1974-1980.
  • Li XL, Chen T, Wong YS, Xu G, Fan RR, Zhao HL, Chan JCN:  Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: an effect attenuated by phycocyanin.The International Journal of Biochemistry & Cell Biology 2011, 43:525-534.
  • Chen T, Mei WJ, Wong YS, Liu J, Liu Y, Xie HS, Zheng WJ: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers.MedChemComm 2010, 1:73-75.
  • Lau WS, Chen T, Wong YS: Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C. Molecular Medicine Report 2010, 3:1023-1030.
  • Chen T, Liu Y, Zheng WJ, Liu J, Wong YS: Ruthenium polypyridyl complexes that induce mitochondria-mediated apoptosis in cancer cells. Inorganic Chemistry 2010, 49:6366-6368.
  • Zheng L, Si J, Wong YS: Ergosterol peroxide and 9,11-dehydroergosterol peroxide from Ganoderma lucidum mycelia suppress the growth of human breast adenocarcinoma MCF-7 cells. International Journal of Medicinal Mushrooms 2009, 11:249-253.
  • Li XL, Xu G, Chen T, Wong YS, Zhao HL, Fang RR, Gu XM, Tong PCT, Chan JCN: Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress modulating JNK and p38 mitogen-activated protein kinase pathways. The International Journal of Biochemistry & Cell Biology 2009, 41:1526-1535.
  • Kong C, Lam C, Chiu L, Ooi VEC, Sun SSM, Wong YS: A rice polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochemical Pharmacology 2009, 77:1487-1496.
  • Chen T, Wong YS: Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. The International Journal of Biochemistry & Cell Biology 2009, 41:666-676.
  • Chen T, Wong YS, Zheng W, Bai Y, Huang L: Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 2008, 67:26-31.
  • Chen T, Wong YS: Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cellular and Molecular Life Sciences 2008, 65:2763-2775.
  • Chen T, Wong YS: In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry 2008, 56:4352–4358.

Research Grants

  • 2010-2012, CUHK Research Committee Direct Grant, Anticancer activities and chemosensitization effects of selenium-containing phycocyanin and its bioactive peptides, $46,443.
  • 2008-2011, National Natural Science Foundation of China (NSFC), 含硒、碲藻藍蛋白的形態分析、抗腫瘤作用及機理研究, RMB 339,000. (Co-I)
  • 2007-2011, Institute of Plant Molecular Biology and Agricultural Biotechnology Research Fund (CUHK-Scheme A), Improvement of micronutrient bioavailability in crops: selenium-enriched rice, $1,200,000.
  • 2002-2005, Research Grants Council-General Research Fund, Isolation and characterization of flavonoid antioxidants in Vigna sinensisseeds, $780,000.
  • 2003-2005, Education Department Quality Education Fund, Multi-school collaboration in the information technology for Hong Kong flora and vegetation, $1,938,000. (Co-I)
  • 2002-2003, Education Department Quality Education Fund, A web-based database and training for Hong Kong flora and vegetation, $1,500,000. (Co-I)
  • 1998-2002, Industry Department Industrial Support Fund, Development of over-the-counter pharmaceutical products based on local medicinal plants. $8,120,000. (Co-I)

Patents

  • 螺旋藻藻藍蛋白的酶解產物及其應用，中華人民共和國國家知識產權局(CN101928743A)

Awards

  • Certificate of Appreciation, Hong Kong Examinations and Assessment Authority
  • CUHK Science Faculty Exemplary Teaching Award
  • CUHK Biology Society Best Teacher Award

Professional Activities

  • Adjunct Professor, Jinan University, China
  • Founding Member, Hong Kong Food Science and Technology Association
  • Member, Institute of Food Technologists, USA
  • Member, American Society of Plant Biologists
  • Member, Guangdong Botanical Society, China
  • Member, Sigma Xi (The Scientific Research Society, USA)

Community Services

  • Technical Expert, Hong Kong Accreditation Service, Innovation and Technology Commission, HKSAR (since 2012)
  • Chief Examiner, Advanced-Level Biology Subject, Hong Kong Examinations and Assessment Authority (1997-2010)