Address	(Office): Rm G88, Science Centre South Block (Lab): Rm G90, Science Centre South Block
Phone	(Office): (852) 3943 6288 (Lab): (852) 3943 6113
Fax	(852) 2603 7246
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	http://www.sls.cuhk.edu.hk/index.php/faculty-and-staff/teaching-staff/26-sls/faculty-and-staff/teaching-staff/82-professor-zhang-jianhua

Education

Positions

• Adjunct Professor of Plant Biology at School of Life Sciences
• Director of State Key Laboratory of Agrobiotechnology

Research Interests

• Plant physiology and molecular biology under environmental stresses.
• Crop production under water-limited condition.  

Representative Publications

1. Xu W, Jia L, Shi W, Baluška F, Kronzucker HJ, Liang J, Zhang J. 2013. Tomato 14-3-3 Protein TFT4 Regulates the Integrated Modulation among Proton Efflux, Basipetal Auxin Transport and PKS5-J3 Pathway in Root Growth Response to Alkaline Stress. Plant Physiology 163, 1817-1828.
2. Xu W, Jia L, Shi W, Liang J, Zhou F, Li Q, Zhang J. 2013. Abscisic acid accumulation modulates auxin transport in the root tip to enhance proton secretion for maintaining root growth under moderate water stress. New Phytologist 197, 135-150.
3. Chen T, Xu Y, Wang J, Wang Z, Yang J, Zhang J. 2013. Polyamines and ethylene interact in rice grains in response to soil drying during grain filling. Journal of Experimental Botany 64, 2523–2538.
4. Jia L, Xu W, Li W, Ye N, Liu R, Shi L, Bin Rahman R, Fan M, Zhang J. 2013. Class III peroxidases are activated in proanthocyanidins-deficient Arabidopsis seeds. Annals of Botany 111, 839-847.
5. Xu W, Ding G, Yokawa K, Baluška F, Li Q, Liu Y, Shi W, Liang J, Zhang J. 2013. An improved agar-plate method for studying root growth and response of Arabidopsis thaliana. Scientific Reports 3, 1273.
6. Xue Y, Duan H, Liu L, Wang Z, Yang J, Zhang J. 2013. An improved crop management increases grain yield and nitrogen and water use efficiency in rice. Crop Science 53, 271-284.
7. Xing Y, Cao Q, Zhang Q, Qin L, Jia W, Zhang J. 2013. MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis. Plant and Cell Physiology 54, 1217-1227.
8. Zhang Z, Chu G, Liu L, Wang Z, Wang X, Zhang H, Yang J, Zhang J. 2013. Mid-season nitrogen application strategies for rice varieties differing in panicle size. Field Crops Research 150, 9-18.
9. Zhi H, Tang L, Xia Y, Zhang J. 2013. Ssk1p-Independent Activation of Ssk2p Plays an Important Role in the Osmotic Stress Response in Saccharomyces cerevisiae: Alternative Activation of Ssk2p in Osmotic Stress. PLoS ONE 8(2): e54867. doi:10.1371.
10. Liu L, Chen T, Wang Z, Zhang H, Yang J, Zhang J. 2013. Combination of site-specific nitrogen management and alternate wetting and drying irrigation increases grain yield and nitrogen and water use efficiency in super rice. Field Crops Research 154, 226-235.

Research Grants

1994-1997. Research Grant Council, Competitive Earmarked Research Grant, "Antitranspiration and anti-growth activities in the xylem stream of plants growing in stressed conditions." HK$ 617,000.

1996-1999. Croucher Foundation, Hong Kong, “Early senescence of wheat at grain-filling time under water-saving cultivation.” HK$ 858,000.

2000-2003. Research Grant Council, Competitive Earmarked Research Grant,, "Soil drying in relation to the remobilization of carbon reserve during grain-filling period of rice and wheat." HK$ 855,500.

2001-2004. Research Grant Council, Competitive Earmarked Research Grant, "Partial rootzone irrigation: its physiological consequences and impact on water use efficiency." HK$ 882,000.

2004-2006. Research Grant Council, Competitive Earmarked Research Grant, "Soil drying at the grain-filling stage of rice and wheat: physiology and its application in crop production. " HK$ 748,800.

2005-2008. Research Grant Council, Competitive Earmarked Research Grant, " Assessment of irrigation methods and rice cultivars for water-limited cultivation. " HK$ 1,071,914.

2007-2011. University Grants Committee, Area of Excellence for Plant and Agricultural Biotechnology, and Hong Kong Baptist University, "Water stress on crop production: from molecular mechanism to crops in the field". HK$ 3,000,000.

2007-2010. Research Grant Council, Competitive Earmarked Research Grant, " Application of partial rootzone irrigation on cotton production in the oases of arid area" HK$ 994,406.

2008-2010. Research Grant Council, General Research Fund " Regulation of the sensitivity of stomatal movement to root signal" HK$ 659,980.

2009-2012. Research Grant Council, General Research Fund " Regulation mechanism of grain filling in inferior spikelets of super rice " HK$ 1,150,000.

2009-2012. Hong Kong Baptist University Strategic Development Fund “Using functional genomics technology to study the molecular mechanism of plant adaptation to water stress and improvement of crop water use efficiency " HK$ 3,650,000.

2011-2013. Kadoori Charitable Foundation: “Partial Rootzone Irrigation (PRI) Water Saving Technique Training Pilot Project in the arid areas of Gansu Province”. RMB 1,030,800.

2012. Ministry of Science and Technology, the National Basic Research Program of China (973 Program), "Mechanism and regulation in enhancing crop water use efficiency", as Co-PI and leader for a subgroup, RMB 40,000,000. 1 Jan 2012-31 Dec 2016. (2012CB114300).

2012 Shenzhen Government, The Peacock Scheme (Overseas Talents Innovation & Entrepreneurship Funding Scheme), as Leader of the Innovative Team on Agricultural Biotechnology, for "Applied research of plant molecular biotechnology on modern agriculture", RMB 30,000,000. Jan 2012-Dec 2016.

2012 The Chinese University of Hong Kong, A special research fund for research project in plant biology, HKD 2,200,000. March 2012-Feb 2015.

2012 The Chinese University of Hong Kong FIS-A project: Cellular and Molecular Studies on Plants for Sustainable Food Supply: Molecular mechanism of plant adaptation to water stress and improvement of crop water use efficiency, HKD 1,300,000, 1 July 2012-31 June 2016 (1907032).

2013 The Chinese University of Hong Kong State Key Laboratory of Agrobiotechnology: The molecular regulation of remobilization of carbon reserve in straws of super rice. HKD 170,000, 23 May 2013-May 2014 (8300059).

2013 The Natural Science Foundation of China (NSFC) Major Research Plan: Network pathways and its mechanisms of IHR1 in integrating the ABA modulation for maintaining primary root elongation under water stress. RMB 2,000,000. 1 Jan 2014-31 Dec 2015 (91317307).

Awards

2014-1 The State Natural Science Award (Second Class) from State Council, China (国家自然科学二等奖) for "Soil water dynamics in the soil-plant system and its control mechanism in the Loess Plateau".

2013-5-29 Chancellor's Distinguished Visitor, University of Missouri, Columbia, USA.

2010-12 The Scientific and Technological Progress Award (First Class) from Ministry of Education, China (教育部科技进步一等奖) Rice cultivation methods for high yield and better use of water and nutrients. 水稻高产与水分养分高效利用栽培技术的研究与应用

2010-12 The Natural Science Award (Second Class) from Ministry of Education, China (教育部自然科学二等奖) Oxidative stress signalling in crops under water stress. 干旱条件下作物应答氧化胁迫的信号转导研究

2009-2 President’s Award for Outstanding Performance in Scholarly Work. Hong Kong Baptist University.

2008-12 Profiled by Nature as one of ‘Five Crop Researchers Who Could Change the World’. Nature 456, 563-568, 2008.

2007-2 The State Scientific and Technological Progress Award (Second Class) from State Council, China (国家科技进步二等奖) for “High effective use of water in agriculture in northwest China” (ref 2006-J-201-2-17-R10).

2008-1 The Scientific and Technological Progress Award (Second Class) from Ministry of Education, China (教育部科技进步二等奖) for “Mechanisms of rice quality formation and cultivation technique” (ref 2007-280).

2002-6. First Class Award for research project “Water-soil-crop relationship and its optimum regulation in Yellow Loess Plateau”, by Yanglin Agricultural Sci-Tech Development and Industry Demonstration Park, Shaanxi, China (ref 03-1-17-R9).

2006-1. The Scientific and Technological Progress Award (Second Class) from Ministry of Education, China (教育部科技进步二等奖) for “Study and application of controlled alternative partial rootzone irrigation and deficit irrigation in crop production” (ref 2005-245).

2004-3. The Science and Technology Award (Fist Class) from Government of Shaanxi Province, China (陕西省科学技术一等奖)for “Water-soil-crop relationship and its optimum regulation in Yellow Loess Plateau”. (ref 03-1-17-R9).

2003-11. The Scientific and Technological Progress Award (Second Class) from Ministry of Education, China (教育部科技进步二等奖) for “The mechanism and regulation of rice grain filling” (ref 2003-232).

2003-11. 2003-11. The Scientific and Technological Progress Award (Second Class) from Ministry of Education, China (教育部科技进步二等奖) for “Water-saving agriculture and sustainable use of water resources” (Ref 2003-251).

Professional Activities

For editorial duties:

Associate Editor of Journal of Experimental Botany (2009- )

Associate Editor of Food and Energy Security (2011- )

Co-Editor of Journal of Integrative Plant Biology (2008- )

Handling Editor of Chinese Bulletin of Botany (2009- )

Associate Editor of Cereal Research Communications (2009-- )

Associate Editor of Plant Physiology Journal (2009-- )

Member of Journal Editorial Boards of

The Crop Journal (2013-      )

Acta Agronomica Sinica (2006-      )

Journal of Integrative Agriculture (2012-       )

Agricultural Research in the Arid Areas (2006-      )

Journal of Science, Technology and Development (2012-      )

Functional Plant Biology (2009-2012)

Journal of Experimental Botany (2002-2008)

Journal of Integrative Plant Biology (formerly Acta Botanica Sinica) (2004-2008)

For decision-making:

Board member, Content Selection & Advisory Board, Scopus, Elsevier (2009-2012 )

Board member, Yunus Center at Asian Institute of Technology (AIT)

Panel member, National Natural Science Foundation of China (NSFC). (2010- )

Panel member, Ministry of Science and Technology (MOST). (2011- )

Member of Selection Panel, Ministry of Education. (2010- )

Member of the Selection Panel for Hong Kong PhD Fellowship Scheme 2010 of University Grants Committee in Hong Kong

Member of Biology Panel in the Research Assessment Exercise (RAE) 2006 of University Grants Committee in Hong Kong

Member of Biology Panel in the Research Assessment Exercise (RAE) 2014 of University Grants Committee in Hong Kong

International Panelist for the First ASAIHL (Association of Southeast Asian Institutions of Higher Learning) Young Scientist Awards (Nov 2008), sponsored by Elsevier.

International Chief Panelist for the First Annual ProSPER.Net-Scopus Young Scientist Award (June 2009), organised by the Promotion of Sustainability in Postgraduate Education and Research (ProSPER.Net), network of leading higher education institutions in Asia and the Pacific areas.

International Chief Panelist for the Young Women Researcher Award 2009 (Nov 2009), organised by the Third World Academy of Science (TWAS), Third World Organization for Women in Science (TWOWS), National Science Centre of Malaysia and Scopus of Elsevier.

International Chief Panelist for the Second Annual ProSPER.Net-Scopus Young Scientist Award (July 2010)

For advices:

Member of Government Advisory Committee, Department of Agriculture, Fisheries and Conservation, Hong Kong Government (20 May 2000-19 May 2005)

Council member (Standing Committee) of Chinese Society of Plant Physiology (2009 -  )

Council member of the Botanical Society of China (2008-2012)

Council member of the Soil Science Society of China (2012-2016)

Council member of the Hong Kong Institute of Science (2008- )

Address	(Office): Rm 107A, Marine Science Laboratory, CUHK (Lab): Rm 107, Marine Science Laboratory, CUHK
Phone	(Office): (852) 3943 6133 (Lab): (852) 3943 6770
Fax	(852) 2603 5391
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Research Associate Professor, School of Life Sciences

Research Interests

•  Coral and Coral Reef Biology, Ecology and Ecophysiology
• Seaweed Ecology, Ecophysiology, Phylogeography and Applications
• Environmental and Functional Responses of Marine Ecosystems

Representative Publications 

• Chui, A.P.Y., Ang, P.O. 2010. Massive overgrow of coral recruits by barnacles in winter low-temperature conditions, Hong Kong, China. Coral Reefs 29: 1017.
• Cheang, C. C., Chu, K. H., Ang, P. O. 2010. Phylogeography of the marine macroalga Sargassum hemiphyllum (Phaeophyceae, Heterokontophyta) in northwestern Pacific. Mol. Ecol. 19:2933-2948.
• Cheang, C. C., Chu, K. H., Fujita, D., Yoshida, G., Hiraoka, M., Critchley, M., Choi, H.G., Duan, D.L., Seriwasa, Y. & Ang, P. O. 2010. Low genetic variability of Sargassum muticum (Yendo) Fensholt (Phaeophyceae) revealed by a global analysis of its native and introduced populations. J. Phycol. 46: 1063-1074.
• Figueroa, F.L., Israel A., Neori, A., Martinez, B., Malta, E.J., Ang, P., Inken, S., Marquardt, R., Abdala, R., Korbee, N. 2010. Effect of nutrient supply on photosynthesis and pigmentation to short-term stress (UV radiation) in Gracilaria conferta (Rhodophyta). Mar. Poll. Bull. 60: 1768–1778.
• Wang H., Chiu, L.M.C., Ooi, V.E.C., Ang, P.O. 2010. A potent antitumor polysaccharide from edible brown seaweed Hydroclathrus clathratus. Botanica Marina 53:265-274.
• Tam, T.W., Ang, P.O. 2009. Catastrophic regime shifts in coral communities exposed to physical disturbances: Simulation results from object-oriented 3-dimensional coral reef model. J. Theor. Biology 259: 193-208.
• Tam, T.W., Ang, P.O. 2009. Structures, dynamics and stability of reef fish assemblages in non-reefal coral communities in Hong Kong, China. Aquatic Conserv: Mar. Freshw. Ecosyst. 19: 301-321.
• Cheang, C.C., Chu, K.H., Ang, P.O. 2008. Morphological and genetic variations in the populations of Sargassum hemiphyllum (Phaeophyceae) in northwestern Pacific. J. Phycol. 44: 855-865.
• Tam, T.W., Ang, P.O. 2008. Repeated physical disturbances and the stability of sub-tropical coral communities in Hong Kong, China. Aquatic Conserv: Mar. Freshw. Ecosyst. 18: 1005–1024.
• Zhao, Fengjuan, Liu Fuli, Liu Jidong, Ang, P. O. Jr., Duan Delin. 2008. Genetic structure analysis of natural Sargassum muticum (Fucales, Phaeophyta) populations using RAPD and ISSR markers. J. Appl. Phycol. 20: 191-198.

Research Grants

• 2011-2013, GRF, Physiological Ecology of the Brown Alga Sargassum in NW Pacific. HK$ 1,044,000.
• 2010-2012, NSFC/RGC Joint Research Scheme, Potential Impacts of Global Climate Change and Environmental Deterioration on Coral Reefs in South China Sea. HK$ 688,200.
• 2009-2011, GRF, Phylogeography and Morphological Analysis of the Brown Alga Sargassum from the South China Sea (RGC Earmarked Grant), HK$ 783,967.
• 2008-2009, AFCD, Provision of Services on Research Collection and Study on Octocorals and Black Corals in Hong Kong Waters Extension (AFCD, HKSAR Government), HK$ 300,000.
• 2007-2009, NSFC/RGC Joint Research Scheme, Genetic and Propagation Study of Brown Algae Sargassum spp. HK$ 685,000.
• 2006-2008, AFCD, Provision of Services on Research Collection and Study on Octocorals and Black Corals in Hong Kong Waters (AFCD, HKSAR Government), HK$ 695,000.
• 2006-2007, Ocean Park Conservation Foundation, An Evaluation of the Effectiveness of Sha Chau and Lung Kwu Chau Marine Park (SLMP) as a Sanctuary for the Chinese White Dolphin (CWD) HK$ 138,000.

Professional Activities

• Editorial Board, Journal of Phycology
• Executive Council, Asia Pacific Phycological Association
• Executive Council, International Society for Applied Phycology
• Executive Council, Asia Pacific Marine Biotechnology Society
• Steering Committee, Asia Pacific Coral Reef Society
• Advisory Committee, Hong Kong Ocean Park Conservation Foundation 

Address	(Office): Rm 178, Science Centre South Block (Lab): Rm 193, Science Centre South Block
Phone	(Office): (852) 3943 4170 (Lab): (852) 3943 6118
Fax	(852) 2603 7246
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Professor, School of Life Sciences
• Director, Centre for Protein Science and Crystallography
  
• Assistant Dean (Student Affairs), Faculty of Sciences
• Fellow, Shaw College

Research Interests

• Structure-function studies of macromolecular assembly in pathogenic bacteria
  
• Structure-function studies of metabolic enzymes
  

Representative Publications

1. Lu, P., Zhang, H., Gao, Y., Jia, X., Liu, Z., Wang, D., Au, S.W.*, Zhang, Q.*(2022) Cryo-electron tomography reveals the roles of FliY in Helicobacter pylori flagellar motor assembly. mSphere 7(1):e0094421. 
2. Wang, K.*, Chan, Y.C., So, P.K., Liu, X., Feng, L., Cheung, W.T., Lee, S.S., Au, S.W.*(2021). Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7-hydroxyl bile acids. Lipid Res. 62:100074.
3. Lam, W. W., Sun, K., Zhang, H. & Au, S.W.*(2020) Crystal structure of flagellar export chaperone FliS in complex with flagellin and HP1076 of Helicobacter pylori. Front Microbiol. 11:787-
4. Zhang, K., Zhang, H., Li, S., Pintille, G., Mou, T.C., Gao, Y., Zhang, Q., van den Bedem, H., Schmid, M., Au, S.W.* & Chiu, W*. (2019) Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies near-atomic resolution. Proc Natl Acad Sci USA 116:6800-6805.
5. Lam, K.H., Xue, C., Sun, K., Zhang, H., Lam W.W.L., Zhu, Z., Ng, J.T.Y., Sause, W.E, Lertsethtakarn, P., Lau, K.F., Ottemann, K.M. & Au, S.W.*(2018) Three SpoA-domain proteins interact in the creation of the flagellar Type III secretion system of Helicobacter pylori. J Biol Chem 293:13961-73
6. Xue, C., Lam, K.H., Zhang, H., Sun, K., Lee, S.H., Chen, X. & Au, S.W.*(2018) Crystal structure of the FliF-FliG complex from Helicobacter pylori yields insight into the assembly of the motor MS-C ring in the bacterial flagellum. J Biol Chem 293:2066-2078.
7. Zhang, H., Lam, K.H., Lam, W.W.L., Wong, S.Y.Y., Chan, V.S.F. & Au, S.W.*(2017) A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. Mol Microbiol 106:690-703.
8. Chen, X., Cheng, H.F., Zhou, J., Chan, C.Y., Lau, K.F., Tsui, S.K. & Au, S.W.*(2017) Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis. J Biol Chem 292:16880-16890.
9. Li, J., Lam, W.W., Lai, T.W. & Au, S.W.*(2017) Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K+ efflux. Biochemical and Biophysical Research Communications, 493:1115-1121.
10. Lam, H., Lam, W.W., Wong, J.Y., Chan, L.C., Kotaka, M., Ling, T.K., Jin, D.Y., Ottemann, K.M., & Au, S.W.*(2013). Structural basis of FliG-FliM interaction in Helicobacter pylori. Mol Microbiol 88(4), 798-812. (Selected for cover image)
11. Lam, H., Ip, W.S., Lam, Y.W., Chan, S.O., Ling, T.K., & Au, S.W.*(2012). Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching. Structure 20(2), 315-325.
12. Lam, W., Woo, E.J., Kotaka, M., Tam, W.K., Leung, Y.C., Ling, T.K. & Au, S.W.*(2010). Molecular interaction of flagellar export chaperone FliS and cochaperone HP1076 in Helicobacter pylori. FASEB J 24(10), 4020-4032.

Honors and Awards

• Suffrage Science Heirloom, MRC London Institute of Medical Sciences (LMS), UK, 2014
• Croucher Foundation Postdoctoral Fellowship, 1998

Research Grants

* RGC General Research Fund (GRF)

• 2022/23: Structure-function study of C-terminal processing protease CtpA and its association with Cag type IV secretion system in Helicobacter pylori 
• 2019/20: Structural studies of vacuolating cytotoxin VacA from Helicobacter pylori
• 2018/19: Structure-function studies of ESX-5 associated PE/PPE proteins in Mycobacterium tuberculosis
• 2014/15: Molecular interactome and functional characterization of the Helicobacter pylori export chaperone FliS
• 2013/14: Dissecting the interactome of motor switch complex and the functional importance of FliG-VacA interaction in H. pylori
• 2012/13: Molecular basis of flagellar rotational switching: Structural study of FliF-FliG assembly
• 2010/11: Understanding the molecular architecture of motor switch complex in Helicobacter pylori
• 2006/07: Structural Characterization of Flagellar Export Chaperon FliS of Helicobacter Pylori
• 2005/06: Proteomic Approach for Specific Identification of SUMO Proteases Substrates
• 2004/05: Structural and Functional Studies of SUMO E3 Ligases and SUMO Specific Proteases
  
  

* Health and Medical Research Fund

• 2018/19: Study of the type VII secretion system in Mycobacterium tuberculosis
• 2017/18: Dissecting the Roles of PE-PPE Subsets in ESX-5 Duplicated Regions in Mycobacterium Tuberculosis
  
• 2014/15: Structure-based screening for G6PD stabilizers to overcome primaquine-induced hemolysis in anti-malaria treatment
• 2013/14: Role of HP1076 in type IV secretion pathway in H. pylori
• 2012/13: Generation of PE-PPE interactome of Mycobacterium tuberculosis

* NSFC/RGC Joint Research Scheme

• 2013/14: Structural studies of flagellar motor switch from H. pylori: A combination of X-ray crystallography and cryo-electron microscopy approaches

* NSFC-General Programme

• 2013/14: Stoichiometry analysis of flagellar motor switch complex in Helicobacter pylori

Professional Activities

• Treasurer, Federation of Asian and Oceanian Biochemists and Molecular Biology (FAOBMB), 2020-2022
• Academic Editor, PLoS One, 2014 - present
• Secretary, Hong Kong Society of Biochemistry and Molecular Biology (HKSBMB), 2007-2017

Address	(Office): Rm 509B, Mong Man Wai Building (Lab): Rm 509A, Mong Man Wai Building
Phone	(Office): (852) 3943 4021 (Lab): (852) 3943 8032
Fax	(852) 2603 7732
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	i. http://www.bch.cuhk.edu.hk/LDR/LDR_news.html ii. http://www.bch.cuhk.edu.hk/LDR/LDR_publication.aspiii. iii. http://scholars.croucher.org.hk/scholars/chan-ho-yin-edwin

Education

Positions

• Professor, School of Life Sciences
• Director, Biochemistry Programme
• Deputy Director, Natural Sciences Programme, Science Faculty
• Director, Laboratory of Drosophila Research
• Warden, Postgraduate Halls

Research Interests 

• Human disease modelling
• Cellular, genetic and biochemical analyses of RNA and protein toxicity in neurological diseases
• Therapeutic intervention of neurological diseases

Representative Publications

• Chen, Z.S., Ou, M., Taylor, S., Dafinca, R., Peng, S.I., Talbot, K.* and Chan, H.Y.E.* (2023) Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulate Wnt/b-catenin pathway in C9ALS/FTD. Nat. Commun. 14(1):8420
• An, Y., Chen, Z.S., Chan, H.Y.E.* and Ngo, J.C.K.* (2022) Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases. Nucl. Acids Res. 50(13), 7655-7668.
• Peng, S.I., Leong, L.I., Sun, J.K., Chen, Z.S., Chow, H.M. and Chan, H.Y.E.* (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Mol. Ther. Nucleic Acids 29, 102-115.
• Peng, S., Guo, P., Lin, X., An, Y., Sze, K.H., Lau, M.H.Y., Chen, Z.S., Wang, Q., Li, W., Sun, J.K., Ma, S.Y., Chan, T.F., Lau, K.F., Ngo, J.C.K., Kwan, K.M., Wong, C.H., Lam, S.L., Zimmerman, S.C., Tuccinardi, T., Zuo, Z., Au Yeung, H.Y., Chow, H.M. and Chan, H.Y.E.* (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proc. Natl. Acad. Sci. USA. 118(19) e2022940118
• Chen, Z.S., Huang, X., Talbot, K. and Chan, H.Y.E.* (2021) A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell Death Dis. 12(2):136
• Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.* and Chan, H.Y.E.* (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Mol. Ther. Nucleic Acids 16, 172-185.
• Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Chan, T.F., Lau, K.F., Ngo, J.C., Wong, W.T., Kwan, K.M. and Chan, H.Y.E.* (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative diseases. EMBO Rep. 19, e45419
• Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595.
• Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.
• Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA. 109, 13428-13433. 

Research Grants

• 2024-2026, Research Grants Council (RGC) GRF Grant, Investigating the heterozygous mutational effect of the CCDC88C gene on causing spinocerebellar ataxia, $1,592,000
• 2021-2022, Research Grants Council (RGC) GRF Grant, The role of adhesion molecule FasII/NCAM in synaptic dysfunction and neurodegeneration in myotonic dystrophy type I, $892,655
• 2020-2022, Research Grants Council (RGC) GRF Grant, How can we handle DNA damage induced by toxic RNAs?, $1,097,419
• 2019-2020, Research Grants Council (RGC) GRF Grant, Investigating the role of PAPD5 and its target microRNAs in RNA toxicity of polyglutamine diseases., $677,160
• 2016-2017, Research Grants Council (RGC) GRF Grant, Dissecting the regulatory mechanism of ubiquitin E3 ligase activity and understanding the importance of such regulation in polyglutamine pathogenesis., $768,202
• 2015-2019, The French National Research Agency (ANR)/Research Grants Council (RGC) Joint Research Scheme, Refining the bioactivity of P42, a hit therapeutic peptide, and developing a combined therapeutic peptide approach for treating Huntington’s Disease., $2,540,083
• 2015-2017, Research Grants Council (RGC) GRF Grant, Characterization of a novel pathogenic pathway of Huntington's Disease., $877,717
• 2014-2017, Research Grants Council (RGC) CRF Grant, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors., $7,044,220
• 2014-2016, Research Grants Council (RGC) GRF Grant, Characterization of a novel type of protein nuclear export signal in polyalanine expansion disease proteins., $866,032
• 2013-2015, Health and Medical Research Fund (HMRF) Grant, An inhibitory peptide approach to simultaneously target RNA and protein toxicities in polyglutamine degeneration., $999,908
• 2013-2015, Research Grants Council (RGC) GRF Grant, The role of nucleolin in CAG trinucleotide repeat-mediated RNA toxicity., $790,000
• 2009-2012, Research Grants Council (RGC) GRF Grant, Probing the nuclear transport role of the mutant polyglutamine domain in neurodegeneration., $929,247
• 2009-2011, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Investigating the involvement of P13K/PDK-1/Akt pathways and Notch signals in SARS-CoV Membrane-induced apoptosis., $741,448
• 2009-2010, Cure Huntington’s Disease Initiative Foundation Early Discovery Initiative Fund, USA, Using the 3B5H10 Monoclonal Antibody to Investigate Huntingtin Oligomer and Toxicity in vivo., $444,149
• 2004-2007, Research Grants Council (RGC) Earmarked Grant, Nucleocytoplasmic transport and polyglutamine toxicity: A cellular genetic study., $1,265,677
• 2004-2006, Research Fund for the Control of Infectious Diseases Research (RFCID) Grant, Molecular and Genetic Characterization of the SARS Coronavirus Auxiliary Protein X1 in Drosophila., $675,144
• 2003-2007, Research Grants Council (RGC) Earmarked Grant, Genetic and proteomic studies of chaperone-mediated suppression of polyglutamine toxicity in Drosophila., $1,203,000

Patents

• Chan, H. Y. E.; Ngo, J. C.; Wong, C.; Zhang, Q.; Peng, S. Small molecule inhibitors targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US 10,143,666, Dec 4, 2018
• Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitors targeting C9ORF72 hexanucleotide repeat-mediated neurodegeneration. U.S. Patent US-2018-0214515-A1, August 2, 2018
• Chan, H.Y.E.; Ngo, J.C.; Zhang, Q. Peptidylic inhibitor targeting CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent US-2017-0233442-A1, August 17, 2017
• Chan, H.Y.E.; Jensen, K.J.; Ngo, J.C.; Sorensen, K.K.; Zhang, Q.; Zuo, Z. P3 Peptidylic inhibitors for treating CAG-repeat RNA toxicity in polyglutamine diseases. U.S. Patent 62/465,513, March 10, 2017
• Chan, H. Y. E.; Tsoi, H.; Ngo, J. C.; Lau, K. F. Therapeutic approach for polyglutamine degeneration. U.S. Patent US 9,297,798, March 29, 2016

Awards

• 2014 Churchill College Visiting By-Fellowship, University of Cambridge, UK
• 2011 Genetics Society of China Thirteenth Ju-Chi Li Animal Genetics Prize (第十三届李汝祺动物遗传学奖)
• The 2009 Young Researcher Award, The Chinese University of Hong Kong
• The 2009 Faculty Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong

 
Professional Activities

• Council Member, Genetics Society of China
• Member, Biology and Medicine Panel (Joint Research Scheme), Research Grants Council (RGC) of Hong Kong
• Member, Ataxia Global Initiative, a worldwide multi-stakeholder research platform to systematically enhance trial-readiness in degenerative ataxias
• Associate Editor, Frontiers in Neurodegeneration
• Founding member, The Hong Kong Young Academy of Sciences
• Topic Editor, Frontiers in Cellular Neuroscience
• Editoral Board, Advances in Alzheimer's Disease
• Editoral Board, RNA & DISEASE
• Member, Scientific Advisory Committee, Society for Research on the Cerebellum

Others

• Session Chair (Models and Mechanism 1), Pan-Asian Consortium for Treatment and Research in ALS (PACTALS), Malaysia, 2023
• Co-Founder, Rare Power Limited
• Member, Charter of the Ataxia Global Initiative working group, Ataxia Global Initiative
• Member, Medical Advisory Board, Advancing CTNNB1 Cures and Treatments Inc.
• Member, Academic Committee of Asia Pacific Drosophila Neuroscience Conference, Academia Sinica, Taiwan, 2019
• Organizer, Inaugural Asia-Pacific Drosophila Neurobiology Conference, Wuhan, China, 2017
• Session Chair (Drosophila models for human diseases), 2nd Asia-Pacific Drosophila Research Conference, Seoul, Korea, 2013
• Chairperson, Scientific and Medical Advisory Committee, Hong Kong Spinocerebellar Ataxia Association, 2012 – present

Current Academic/Research Positions of Lab Alumni

• Dr. An Ying, Research Assistant Professor, School of Life Sciences, Southern University of Science and Technology, China
• Dr. Chan Kam Leung, Lecturer, School of Chinese Medicine, CUHK
• Dr. Chan Priscilla, Director of Research & Development (Healthcare), Nano and Advanced Materials Institute Limited, HK
• Dr. Chen Stephen, Postdoc Fellow, University of Oxford, UK
• Dr. Cheng Tat Cheung, CryoEM scientist, University of Gottingen, Germany
• Dr. Chuck Chi Pang, Research Scientist, Polytide Technology Inc., Canada
• Dr. Choi Ching Gee, Postdoc Fellow, HKU
• Professor Choi Jonathan, Associate Professor, Department of Biomedical Engineering, CUHK
• Dr. Huen Macy, Manager, Technology Transfer and Commercialization, Intellectual Property Management, Hong Kong Polytechnic University
• Dr. Koon Alex Chun, Senior Lecturer, School of Life Sciences, CUHK
• Dr. Law Carman, Postdoc Fellow, City University of Hong Kong
• Dr. Li Li, Postdoc Fellow, College of Physics Science and Technology, Shenzhen University
• Dr. Ng Nelson, Postdoc Fellow, HKU
• Dr. Peng Isaac, Project Scientist, UC Irvine, USA
• Professor Wong Siu Lun Alan, Associate Professor, School of Biomedical Sciences, HKU
• Dr. Wu Chi Chung, Junior Group Leader, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University
• Dr. Zhang Qian, Clinical Trial Manager, Medpace, Bavaria, Germany