Address	(Office): Rm 604, Mong Man Wai Building, CUHK (Lab): Rm 612A, Mong Man Wai Building, CUHK
Phone	(Office): (852) 3943 1530 (Lab): (852) 3943 0577
Fax	(852) 2603 7732
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web

Education

Positions

• 2019+         Assistant Professor, School of Life Sciences, CUHK
• 2015-2019   Junior Fellow, Institute for Advanced Study, HKUST
• 2015-2019   Research Assistant Professor, Division of Life Science, HKUST
• 2013-2015   Postdoctoral Fellow, Division of Life Science, HKUST
• 2010-2011   Postdoctoral Fellow, School of Electrical and Computer Engineering, Cornell University, USA

Research Interests

• Metabolic plasticity and neurodegenerative disorders
• Mitochondrial bioenergetics
• Aging and cellular senescence

 Representative Publications

        After joining CUHK

1. Deng Wu, Jacquelyne Ka Li Sun, Kim Hei-Man Chow. Neuronal cell cycle re-entry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence. PloS Biology. 2024 Apr 23;22(4):e3002559.  doi: 10.1371/journal.pbio.3002559 [Corresponding author, Impact factor₂₀₂₃: 9.8] (Journal Highlight)
2. Xiaoying Liu, Linyu Xu, Yutong Song, Zhihao Zhao, Xinyu Li, Cheuk-Yiu Wong, Rong Chen, Jianxiong Feng, Yitao Gou, Yajing Qi, Hei-Man Chow, Shuhuai Yao, Yi Wang , Song Gao, Xingguo Liu, Liting Duan. Force-induced tail-autotomy mitochondrial fission and biogenesis of matrix-excluded mitochondrial-derived vesicles for quality control. PNAS. 2024 Apr 2;121(14):e2217019121.  doi: 10.1073/pnas.2217019121. [11^th out of 16 authors, Impact factor₂₀₂₂: 12.779]
3. Dina Popova, Jacquelyne Ka Li Sun, Hei-Man Chow, Ronald P Hart. A critical review of ethanol effects on neuronal firing: A metabolic perspective. Alcohol: Clinical and Experimental Research. 2024 Jan 12. doi: 10.1111/acer.15266.  [Co-corresponding author, Impact factor₂₀₂₃: 3.455]
4. Deng Wu, Xiaoman Bi, Kim Hei-Man Chow. Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease. Journal of Neuroinflammation. 2024 Jan 4;21(1):1. doi: 10.1186/s12974-023-02987-4. [Corresponding author, Impact factor₂₀₂₃: 9.8]
5. Winnie Wan-Yee Tso, Mike Yat-Wah Kwan, Janette Siu-Yin Kwok, Lok-Kan Leung, Cuixin Li, Yuliang Wang, Mathew Siu-Chun Chow, Anita Man-Ching Tsang, Yiu-Ki Ng, Stella Chim, Chin Ying Chow, Alvin Chi Chung Ho, Sophelia Hoi Shan Chan, SM Tai, Wing Cheong Lee, Victor Chan, Eric Yau, Jacquelyne Ka Li Sun, Hei Man Chow, Yu Lung Lau, Patrick Ip, Jasper Fuk-Woo Chan. Clinical characteristics of children with neurological manifestations due to SARS-CoV-2 omicron infection (2023) Journal of Medical Virology. 2023 Jul;95(7):e28895 [19^th out of 22 authors, Impact factor₂₀₂₂: 20.639]
6. Jacquelyne Ka-Li Sun, Genper Chi-Ngai Wong and Kim Hei-Man CHOW (2023) Crosstalk between DNA damage response and the central carbon metabolic network underlies selective vulnerability of Purkinje neurons in Ataxia-telangiectasia. Journal of Neurochemistry (2023) https://doi.org/10.1111/jnc.15881 [Corresponding author, Impact factor₂₀₂₂: 5.546]
7. Deng Wu, Xiaoman Bi, Peihu Li, Dahua Xu, Jianmin Qiu, Kongning Li, Shaojiang Zheng, Kim Hei-Man Chow. Enhanced insulin-regulated phagocytic activities support extreme health span and longevity in multiple populations. Aging Cell 2023 May; 22(5):e13810. doi: 10.1111/acel.13810 [Co-corresponding author, Impact factor₂₀₂₂: 11.005]
8. Jacquelyne Ka-Li Sun, Deng Wu, Tsun-Ming Lau, Meigui Yang, Ronald P Hart, Kin-Ming Kwan, Ho-Yin Edwin Chan, Hei-Man CHOW. Chronic alcohol metabolism results in DNA repair infidelity and cell-cycle-induced senescence in neurons. Aging Cell 2023 Feb; 22(2):e13772 [Corresponding author, Impact factor₂₀₂₂: 11.005]
9. Chau DDL, Li W, Chan WWR, Sun JKI, Zhai Y, Chow HM and Lau KF (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signalling. FASEB J. 36, e22594 [6^th out of  7 authors, Impact factor₂₀₂₂: 5.834]
10. Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang. Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance. Nature Metabolism volume 4, pages 1287-1305 (2022) [22^nd out of 23 authors, Impact factor₂₀₂₂: 19.865]
11. Genper Chi-Ngai Wong and Kim Hei-Man Chow (2022) DNA damage response-associated cell cycle re-entry and neuronal senescence in brain aging and Alzheimer’s disease. Journal of Alzheimer’s Disease. 2022 Jul 11. doi: 10.3233/JAD-220203 [Corresponding author, Impact factor₂₀₂₂: 4.16]
12. Shaohong Issac Peng, Lok I Leong, Jacquelyne Ka-Li Sun, Zhefan Stephen Chen, Hei-Man Chow and Ho Yin Edwin Chan. (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Molecular Therapy-Nucleic Acids. Vol. 29:102-115 [5^th out of 6 authors, Impact factor₂₀₂₂: 10.183]
13. Zaofeng Yang, Meigui Yang, Hei-Man Chow et al., (2021) Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Acta Biomaterialia; S1742-7061(21)00588-2 [3^rd out of 6 authors, Impact factor_2022: 10.633]
14. Hei-Man Chow, Jacquelyne Ka-Li Sun et al.,. (2021) Low-density lipoprotein receptor-related protein 6 cell surface availability regulates fuel metabolism in astrocytes. Advanced Science. 2021 Aug;8(16):e2004993 [Corresponding and 1^st author, Impact factor₂₀₂₂: 17.521]
15. Shaohong Peng, Pei Guo, Xiao Lin, Ying An, Kong Hung Sze, Matthew Ho Yan Lau, Zhefan Stephen Chen, Qianwen Wang, Wen Li, Jacquelyne Ka-Li Sun, Sum Yi Ma, Ting-Fung Chan, Kwok-Fai Lau, Jacky Chi Ki Ngo, Kin Ming Kwan, Chun-Ho Wong, Sik Lok Lam, Steven C. Zimmerman, Tiziano Tuccinardi, Zhong Zuo, Ho Yu Au-Yeung, Hei-Man Chow, and Ho Yin Edwin Chan. (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. PNAS. 118(19): e2022940118. [22^nd out of 23 authors, Impact factor₂₀₂₂: 12.779] 
16. Ying Zhang, Zhongyu Zhang, Lianwei Li, Kaiyu Xu, Zhanshan Ma, Hei-Man Chow, Karl Herrup, Jiali Li. (2020) Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease. FASEB J. 34(12):16364-16382. [6^th out of 8 authors; Impact factor₂₀₂₂: 5.834]
17. Aifang Cheng, Kai-Hei Tse, Hei-Man Chow et al., (2021) ATM loss disrupts the autophagy-lysosomal pathway. Autophagy 17(8):1998-2010. [3^rd out of 9 authors, Impact factor₂₀₂₂: 13.391]
18. Jiechao Zhou, Hei-Man Chow et al., (2020) Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry 87(8):756-769. [Co-corresponding and co-1^st author, Impact factor₂₀₂₂: 13.437]
19. Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang, Karl Herrup. (2019) Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Nature Neuroscience. 2(11):1806-1819. [Co-corresponding and 1^st author, Highlighted by F1000 Prime as 2 stars article; Impact factor₂₀₂₂: 28.771;]
20. Murali Doraiswamy, Elisha London, Peter Varnum, Barbara Harvey, Shekhar Saxena, Simon Tottman, Sir Philip Campbell, Alvaro Fernández Ibáñez, Husseini Manji, Mohammad Abdul Aziz Sultan Al Olama, I-han Chou, Helen Herrman, Sung-jin Jeong, Tan Le, Caroline Montojo, Bjarte Reve, Karen S. Rommelfanger, Charlotte Stix, Nitish Thakor, Kim Hei-Man Chow, Andrew E. Welchman, and Vanessa Candeias. (2019) Empowering 8 Billion Minds: Enabling Better Mental Health for All via the Ethical Adoption of Technologies. NAM Perspectives. Policy White Paper, National Academy of Medicine, Washington, DC. [20^th out of 22 authors, Impact factor₂₀₂₀: N/A]
    
    
    Before joining CUHK (Selected)

1. Hei-Man Chow, Aifang Cheng et al. (2019) ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. Journal of Cell Biology. 218(3):909-928. [Co-corresponding and 1^st author; Journal Spotlight with Commentary, Impact factor₂₀₂₂: 8.077]
2. Aifang Cheng, Teng Zhao, Kai-Hei Tse, Hei-Man Chow et al. (2018). ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. PNAS. 115(2):E292-E301. [4^th out of 9 authors; Impact factor₂₀₂₂: 12.779]
3. Karl Herrup, Kai-Hei Tse and Hei-Man Chow (2017) Loopholes in the DNA contract kill neurons. Nature Neuroscience.20(9):1192-1194 [Co-corresponding author; Impact factor₂₀₂₀: 28.771]
4. Jianmin Chen, Yanping Chen, Graham Vail, Hei-Man Chow et al. (2016) The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Molecular Neurodegeneration. 11(1):60 [4^th out of 10 authors; Impact factor₂₀₂₂: 18.879]
5. Hei-Man Chow, Karl Herrup. (2015) Genomic integrity and the ageing brain. Nature Reviews Neuroscience. 16(11):672-84. [1^st author; Impact factor₂₀₂₂: 38.775]
6. Hei-Man Chow, Dong Guo et al. (2014) CDK5 activator protein p25 preferentially binds and activates GSK3β. PNAS. 111(45):E4887-95. [1^st author, Impact factor₂₀₂₂: 12.779]
                   
   

Research Grants

1. PI, Young Scientist Fund 2023, NSFC, ATM as a critical mediator of insulin-regulated metabolic flexibility and the related implications in cerebellar ataxia. CYN$ 300,000, 01/01/2024-31/12/2026.
2. PI, Strategic Seed Funding for Collaborative Research Scheme, CUHK-Research Committee, A pilot multi-omics investigation at whole tissue, sub-lobular, and cellular levels to profile the spatial and temporal changes in maturing cerebellum of the Fragile X syndrome—implications in autism. HK$500,000, 1/11/2023-31/10/2025
3. Co-PI, Young Collaborative Research Fund  2021/22. Light Protects Vision: Optogenetic Activation of Trk Signaling for Neuroprotection of Retinal Ganglion Cells in Ocular Diseases. RGC, HK$ 3,755,333, 30/06/2023-29/06/2026.
4. PC, CUHK-Academic Equipment Grant 2021/22/. The Integrated Neuroscience and Metabolic Phenotypic Core (INMPC). HK$3,433,742, 6/03/2022-21/08/2022
5. PI, Early Career Scheme 2021/22, Chronic alcohol consumption induces brain metabolic reprogramming: implications in accelerated brain aging and potentials of senolytics-based therapies. RGC, HK$ 1,185,691, 01/01/2022-31/12/2024.
6. PI, Excellent Young Scientists Fund 2020, Metabolic reprogramming mechanism and regulation in cerebellar ataxia. NSFC, CYN$ 1,200,000, 01/01/2021-31/12/2023.
7. Co-I. Collaborative Research Fund 2019/20, The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong (Project Coordinator: Prof. Liwen JIANG, CUHK). RGC, HK$ 7,439,308, 30/06/2020-29/06/2023.
8. PI, General Research Fund 2019/20, Loss of nuclear estrogen-related receptor-a (ERRa) activity impairs metabolic plasticity and mitochondrial OXPHOS in neurons: Implications of sex differences observed in Alzheimer’s disease. GRF, HK$ 911,408, 01/01/2020-31/12/2022.
9. PI, General Research Fund 2018/19, A novel ATM-NRF1 axis facilitates mito-nuclear communication in response to cellular energy demand—Implications for cerebellar neurodegeneration in Ataxia-telangiectasia. GRF, HK$ 972,000, 01/07/2018-31/12/2021.
10. PI, General Research Fund 2017/18, The Wnt antagonist Dkk1 acts as a bimodal switch of Wnt signaling that controls the neurotrophic versus neurotoxic fates of astrocytes: Implications in the Alzheimer’s disease. GRF, HK$ 819,393, 01/01/2018-31/12/2019.
11. PI, Alzheimer’s Association Research Fellowship 2017. Targeting brain insulin resistance-mediated neuronal dysfunction in AD. Alzheimer’s Association, US$ 175,000, 01/10/2017-31/09/2021.

Patents

1. U.S. Provisional Patent Application No. 63/268,153. Title: A metabolic correction approach for treating accelerated brain aging caused by alcohol misuse. Inventor: Hei-Man Chow.
2. US Patent number US20110098263A1; Title: Hydroxy-Substituted Gold (III) Porphyrin Complexes as Histone Deacetylase Inhibitors; Inventors: CM Che, Yu Wang, Raymond WY Sun; Kim HM Chow.

Awards

1. US National Academy of Medicine (NAM), International Health Policy Fellowship 2023-24 (2023,06)
2. CUHK Faculty of Science, Faculty Exemplary Teaching Award 2021 (2022.08)
3. 2021《JESSICA Most Successful Women Awards》
4. National Natural Science Foundation-Excellent Young Scientist Fund 2020 (優秀青年科學家基金) (2021.01-2023-12)
5. Young Investigator Award--East Meets West Symposium 2019 on 21st Diabetes & Cardiovascular Risk Factors (2019.09)
6. L’Oreal-UNESCO-China Association of Science and Technology—2017 For Women in Science: China Future Female Scientist Award (未来女科学家奖) and China-Hong Kong representative for the 2018 L’Oreal-UNESCO International Rising Talents Award
7. Alzheimer’s Association—Alzheimer’s Association Research Fellowship (2017.10-2021.09)
8. World Economic Forum—Global Future Council Fellowship (2016.11-2019.11)
9. HKUST-Institute for Advanced Study (IAS)—Junior Fellowship (2015.09-2019.06)

Professional Activities

Professional Society Committee/Council Member (Honored service):

2019-2022       Society for Neuroscience—Global Membership Committee (GMC)

2017-2019       Society for Neuroscience—Trainee Professional Development Award (TPDA) Selection Committee

2016-2019       World Economic Forum—Global Future Council (GFC), The Future of Neurotechnologies and Brain Science Council

2015-2018       Society for Neuroscience—Trainee Advisory Committee (TAC)

Professional Society Membership

2018+  Alzheimer’s Association (AA)

2013+  Society for Neuroscience (SfN)

2008+  American Association for Cancer Research (AACR)

Research Proposal Review (Selected):

1. A-T Society Research Grants (UK)
2. Israel Science Foundation Research Grants (Israel)

Manuscript Review (Selected):

1. Nature Review Neurology
2. Science Advances
3. Alzheimer’s Research & Therapy

Others (Research-related news and Interviews)

1. Hong Kong Laurate Forum 香港桂冠論壇—Wonder Women in Science: Inspiring and Empowering the Next Generation https://fb.watch/e_GIfiiCYP/ (July 2022)
2. RTHK 32 凝聚香港-科學界女強人 https://www.youtube.com/watch?v=TXCVt2mfkqM&list=PLuwJy35eAVaIQQ--HY2Q1be3Bbb_Owk8v&index=52 (July 2022)
3. Our Eminent Scientists @ CUHK —Big Data X Traditional Molecular Biology: Decoding Biological Signalling Network: http://www.sci.cuhk.edu.hk/en-gb/faculty/faces-of-cuhk-science/article/539-20-10-hmchow
4. L’Oreal HK—Hong Kong woman scientist selected for 2017 Rising Talents in 14^th China Young Women in Science Fellowships https://www.loreal.hk/en-hk/media/news/2018/jan/hong-kong-woman-scientist-selected-for-2017-rising-talents
5. Nature—Career Feature 27 June 2018
   Title: How to build a lab in East Asia’s science hot sports? https://www.nature.com/articles/d41586-018-05513-2?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf192841411=1
6. Society for Neuroscience—Neuronline—Capital Hill Day March 2018
   Title: If You Get Involved in Science Advocacy, Here’s the Impact You Can Make. https://neuronline.sfn.org/advocacy/if-you-get-involved-in-science-advocacy-heres-the-impact-you-can-make/

Address	(Office): Rm LG89, Science Centre South Block (Lab): Rm LG90, Science Centre South Block
Phone	(Office): (852) 3943 1272 (Lab): (852) 3943 1214
Fax	(852) 2603 6382
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Research Associate Professor, School of Life Sciences
• Principal Investigator, State Key Lab of Agricultural Biotechnology

Research Interests

• Molecular and genetic analysis of seed development in maize
• Carotenoid metabolism and vitamin A fortification in crop seeds
• Regulation of ABA biosynthesis under biotic and abiotic stresses

Representative Publications

• Liu Y, Xiu ZH, Meeley R, Tan BC*. (2013) Empty pericarp5 encodes a pentatricopeptide repeat protein that is required for mitochondrial RNA editing and seed development in maize. Plant Cell 25: 868-883.
• Shen Y., Li C, Meeley R, McCarty DR, Tan BC*. (2013) Embryo defective12 encodes translation initiation factor3 and is essential to maize embryogenesis. Plant J. 74: 792-804.
• Zhang YF, Hou MM, Tan BC*. (2013) The requirement of WHIRLY1 for embryogenesis is dependent on genetic background in maize. PLoS One 8(6): e67369.
• Tan BC*, Chen Z, Shen Y, Zhang Y, Lai J, Sun SSM. (2011) Identification of an active new Mutator transposable element in maize. Genes Genomes Genetics 1:293-302.
• Messing SA, Gabelli SB, Echeverria I, Vogel, JT, Guan JC. Tan BC, Klee HJ, McCarty DR, Amzel LM*. (2010) Structural insights into maize Viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell 22: 2970-2980.
• Vogel JT, Tan BC, McCarty DR, Klee HJ*. (2008) The carotenoid cleavage dioxygenase 1 enzyme has broad substrate specificity, cleaving multiple carotenoids at two different bond positions. J. Biol. Chem. 283: 11364-1137.
• Tan BC*, Joseph LM, Deng WT, Liu LJ, Li QB, Cline K, McCarty DR. (2003) Molecular characterization of the Arabidopsis nine-cis expoxycarotenoid dioxygenase gene family. Plant J. 35: 44-56.
• Tan BC*, Cline K, McCarty DR. (2001) Localization and targeting of VP14 epoxy-carotenoid dioxygenase to the chloroplast membrane. Plant J. 27: 373-382.
• Tan BC, Schwartz S, Zeevaart JA, McCarty DR*. (1997) Genetic control of abscisic acid synthesis in maize. Proc. Natl. Acad. Sci. USA 94: 12235-12240.
• Schwartz S, Tan BC (Co-first author), Gage DA, Zeevaart JA, McCarty DR*. (1997) Specific oxidative cleavage of carotenoids by VP14 of maize. Science 276, 1872-1875.

Research Grants

• 2014-2016, Research Grants Council, GRF. "Functional analysis of SMALL KERNEL 11 and identification of its interacting proteins". (PI, HK$ 736,128).
• 2013-2015, Research Grants Council, GRF. "Functional analysis of Empty pericarp 5 in maize seed development". (PI, HK$ 890,000).
• 2012-2014, Research Grants Council, GRF. "Functional analysis of EMB15 in maize seed development". (PI, HK$ 1,265,000).
• 2010-2012, Research Grants Council, GRF, "Genetic and functional dissection of Emb12 and Emb14 in maize embryo development", (PI, HK$1,724,595).
• 2012-2015, National Science Foundation of China, "Cloning and functional analysis of Small kernel2 gene in maize". (PI, RMB 550,000).
• 2012-2016, Shenzhen Peacock Scheme, "Applied research of plant molecular biotechnology on modern agriculture". (Co-PI, RMB 30,000,000).
• 2012-2015, CUHK Shenzhen Research Institute Start-up Support Scheme, "Functional analysis of SMK2 in maize". (PI, HK$ 250,000).
• 2009-2011, China Transgenic Initiative, Sub-project: Identification and mechanistic study of genes related to crop yield, nutrition and stress resistance", (PI, RMB500,000; HK$700,000).
• 2008-2011, Area of Excellence Scheme, Sub-project: Functional genomics of seed development in maize and rice. (PI, HK$1,650,000).
• 2005-2008, National Science Foundation (USA), Functional analysis of plant carotenoid dioxygenases", (Co-PI, US$600,000).

Professional Activities

• Editorial Board, Bulletin of Botany
• Member of the International Association for Plant Biotechnology (IAPB)

Address	(Office): Rm G78, Science Centre South Block (Lab): LG 105, Run Run Shaw Science Building
Phone	(Office): (852) 3943 6148 (Lab): (852) 3943 6280
Fax	(852) 2603 5646
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Research Professor, School of Life Sciences

Research Interests

• Fish osmoregulatory physiology
• Biology of stress and heat stock proteins
• Fish diseases

Representative Publications

• Deane, E. E., Luk, J. C. Y. and Woo, N. Y. S. (2011) Aquaporin 1a expression in gill, intestine and kidney of the euryhaline silver sea bream. Frontiers in Physiology 2: 39 doi: 10.3389/fphys.2011.00039
• Deane, E. E. and Woo, N. Y. S. (2011) Advances and perspectives on the regulation and expression of piscine heat shock proteins. Reviews in Fish Biology and Fisheries 21: 153-185.
• Leung, L. Y., and Woo, N. Y. S. (2010) Effects of growth hormone, insulin-like growth factor I, triiodothyronine, thyroxine, and cortisol on gene expression of carbohydrate metabolic enzymes in sea bream hepatocytes. Comparative Biochemistry and Physiology A157: 272-282.
• Jia, A., Woo, N. Y. S., and Zhang, X.-H. (2010) Expression, purification and characterization of thermolabile hemolysin (TLH) from Vibrio alginolyticus. Diseases of Aquatic Organisms90: 121-127.
• Bai, F., Sun, B., Woo, N. Y. S., and Zhang, X-H (2010) Vibrio harveyi hemolysin induces ultrastructural changes and apoptosis in flounder (Paralichthys olivaceus) cells. Biochemical and Biophysical Research Communications395: 70-75.
• Deane, E. E. and Woo, N. Y. S. (2009) Modulation of fish growth hormone levels by salinity, temperature, pollutants and aquaculture related stress: a review. Reviews in Fish Biology and Fisheries 19: 97-120.
• Kwong, A. K. Y. and Woo, N. Y. S. (2008) Prolactin-releasing peptide, a possible modulator of prolactin in the euryhaline silver sea bream (Sparus sarba): a molecular study. General and Comparative Endocrinology 158: 154-160.
• Man, A. K. Y. and Woo, N. Y. S. (2008) Upregulation of metallothionein and glucose-6-dehydrogenase expression in silver sea bream, Sparus sarba, exposed to sublethal levels of cadmium. Aquatic Toxicology 89: 214-221.
• Deane, E. E., Zhou, L. R. and Woo, N. Y. S. (2006) Cortisol can be pro- or anti-apoptotic in sea bream cells: potential role of HSP70 induction for cytoprotection. Molecular and Cellular Endocrinology 259: 57-64.
• Deane, E. E. and Woo, N. Y. S. (2006) Tissue distribution, effects of salinity acclimation and ontogeny of aquaporin 3 in the marine teleost silver sea bream (Sparus sarba). Marine Biotechnology 8: 663-671.

Research Grants

• 2011-2013: RGC GRF, Function and regulation of cystic fibrosis transmembrane regulator (CFTR) in gill and intestine of the euryhaline seabream. PI. $690,000
• 2009-2012: RGC GRF: Do salinity and hormones influence apoptosis and transformation of gill chloride cells? PI, $1,636,666.
• 2005-2008: RGC Earmarked Grant: Molecular strategies of temperature acclimation in the sea bream. PI, $815,957.
• 2003-2006: RGC Earmarked Grant: Role of aquaporin water channels in the osmoregulatory strategy of the euryhaline marine teleost Sparus sarba. PI: $1,388,000.
• 2002-2005: RGC Earmarked Grant: Growth hormone and insulin-like growth factor – I as anti-apoptotic factors via modulated HSP70 expression in sea bream. PI: $1,354,000.
• 2001-2004 RGC Earmarked Grant: Stimulation of glucose-6-phosphate dehydrogenase activity in sea bream: metabolic significance and potential applications. PI: $1,078,000.
• 2000-2002 RGC Earmarked Grant: Modulation of gill Na+-K+-ATPase expression by salinity and hormonal factors in the sea bream, Sparus sarba. PI: $679,200.
• 1999 – 2002 RGC Earmarked Grant: Protective effects of heat shock protein 70 (HSP70) against environmental and pathogenic stress in the marine teleost Sparus sarba. PI: $920,640.
• 1998-2000 RGC Earmarked Grant: Enhancing immunological competence of silver sea bream (Sparus sarba) through the combined application of salinity adaptation, hormonal factors and specific vaccines. PI: $645,000.
• 1997-2000: RGC Earmarked Grant: Evaluation of novel microencapsulated formulations for the improved survival and development of cultured marine fish larvae. PI: $849,500.
• 1995-1997: RGC Earmarked Grant: An iso‑osmotic marine fish factory. PI: $531,000.
• 1991-1994: RGC Earmarked Grant: An assessment of the feasibility of developing ‘factory‑based' marine fish culture. PI; $400,000.
• 2004-2009: Area of Excellence (AoE): Centre for Marine Environmental Research and Innovative Technology (MERIT): $925,000.
• 2009-2012: Area of Excellence (AoE) Extension: Centre for Marine Environmental Research and Innovative Technology (MERIT): $300,000.
• 2009-2011: NSFC-RGC Joint Research Scheme: Elucidation of the role played by Vibrio virulence factors on cytoprotection and apoptosis in fish cells. PI: $656,400.

 Awards

• Ocean Services Award, PACON International, USA
• Distinguished Member Award, PACON International, USA

Professional Activities

• Editorial Board, Frontiers in Aquatic Physiology
• Editorial Board, Journal of Marine Biology
• Editorial Board, Open Marine Biology Journal

Others

• Partner Laboratory - State Key Laboratory in Marine Pollution

Address	(Office): Rm G01D, Science Centre East Block (Lab): --
Phone	(Office): (852) 3943 0549 (Lab): --
Fax
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	--

Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Fat and cholesterol metabolism
• Anti-aging and nutraceutical
• Food Toxicology
  

Representative Publications

1. Li YM, Chan HYE, Huang Y, Chen ZY. Green Tea Catechins Upregulate Superoxide Dismutase and Catalase in Fruit Flies (2007). Molecular Nutrition and Food Research 51(5):546-54.
2. Li YM, Chan HYE, Yao XQ, Huang Y, Chen ZY. Green Tea Catechins and Broccoli Reduce Fat-Induced Mortality in Drosophila melanogaster (2008). Journal of Nutritional Biochemistry 19,376-383.
3. Li YM, Chan HYE, Huang Y, Chen ZY. Broccoli (Brassica oleracea var. botrytis L.) improves the survival and up regulates endogenous antioxidant enzymes in Drosophila melanogaster challenged with reactive oxygen species (2008). Journal of the Science of Food and Agriculture 88(3): 499-506.
4. Peng C, Chan HY, Li YM, Huang Y, Chen ZY. Black Tea Theaflavins extend the Lifespan of Fruit Flies (2009). Experimental Gerontology 44(12):773-83.
5. Peng C, Wang Z, Chen J, Jian R, Wang L, Li YM, Zuo Y, Liu Y, Lei L, Ma KY, Huang Y, Chen ZY. Biology of ageing and role of dietary antioxidants (2014). BioMed Research International http://dx.doi.org/10.1155/2014/831841
6. Wang L, Li YM, Lei L, Liu Y, Wang X, Ma KY, Chen ZY. Cranberry anthocyanin extract prolongs lifespan of fruit flies (2015). Experimental gerontology 69, 189-195.
7. Wang L, Li YM, Lei L, Liu Y, Wang X, Ma KY, Zhang C, Zhu H, Zhao Y, Chen ZY. Purple sweet potato anthocyanins attenuates fat-induced mortality in Drosophila melanogaster (2016). Experimental Gerontology, 82, 95-103.
8. Lei L, Li YM, Wang X, Liu Y, Ma KY, Wang L, Man SW, Zhang C, Chen ZY. Plasma Triacylglycerol-lowering activity of citrus polymethoxylated flavones is mediated by modulating the genes involved in lipid metabolism in hamsters (2016). European Journal of Lipid Science and Technology 118, 147-156.
9. Zhang C, Zhang R, Li YM, Liang N, Zhao Y, Zhu H, He Z, Liu J, Hao W, Jiao R, Ma KY, Chen ZY. Cholesterol-Lowering Activity of Tartary Buckwheat Protein (2017). Journal of Agricultural and Food Chemistry 8:65(9), 1900-1906.

Professional Activities

• Registered Nutritionist, Association for Nutrition, UK
• Executive Committee, Hong Kong Nutrition Association
• Honorary Secretary, Hong Kong Nutrition Association
• Member (Secretary), Working Task Force of Nutritionist Accreditation, Hong Kong Nutrition Association
• Member, Working Task Force of StartSmart@School Campaign, Department of Health, HKSAR