Professor WONG Yum Shing


(Office): Rm 286, Science Centre South Block

(Lab): Rm G92, Science Centre South Block

People WYS2


(Office): (852) 3943 6389

(Lab): (852) 3943 6121

Fax (852) 2603 5745
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
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1985 Ph.D. University of California at Davis
1977 M.Phil.. The Chinese University of Hong Kong
1975 B.Sc. The Chinese University of Hong Kong


  • Associate Professor, School of Life Sciences

Research Interests

  • Plant Physiology and Biochemistry
  • Phytochemicals and Nutraceuticals
  • Bioactivities of Natural and Synthetic Compounds

Representative Publications 

  • Fan C, Chen J, Wang Y, Wong YS, Zhang Y, Zheng W, Cao W, Chen T: Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering ROS-mediated DNA damage and inactivation of ERK pathway. Free Radical Biology & Medicine 2013. (in press) (
  • Wang YD, Wang X, Wong YS: Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilization with selenite. Food Chemistry 2013, 141(3):2385-2393.
  • Huang Y, He L, Liu W, Fan C, Zheng W, Wong YS, Chen T: Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials 2013, 34(29):7106-7116.
  • Gao S, Chen T, Choi MY, Xue J, Wong YS: Cyanidin reverses cisplatin-induced nephrotoxicity through inhibition of ROS-mediated DNA damage and modulation of ERK and AKT pathways. Cancer Letters 2013, 333(1):36-46.
  • Liu Y, Chen T, Liu J, Wong YS: Identification of fluorescent ruthenium complexes containing imidazole derivatives as a new class of apoptosis inducers by living cell real-time imaging. MedChemComm 2013, 4(5):865-869.
  • Su J, Lai H, Chen J, Li L, Wong YS, Chen T, Li X: Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage. PLOS ONE 2013, 8(5): e63502.
  • Liu C, Liu Z, Li M, Li X, Wong YS, Ngai SM, Zheng W, Zhang Y, Chen T: Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLOS ONE 2013, 8(1): e53945.
  • Wang YD, Wang X, Ngai SM, Wong YS: Comparative proteomics analysis of selenium responses in selenium-enriched rice grains. Journal of Proteome Research 2013, 12:808-820.
  • Luo Y, Chen T, Huang X, Wang Y, Wong YS, Zheng W: Synthesis and anticancer activity of a novel selenadiazole derivative and its interaction with bovine serum albumin. Acta Chimica Sinica 2012, 70(11):1295-1303.
  • Wang Y, Wang X, Wong YS: Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice. Journal of Proteomics 2012, 75(6):1849-1866.
  • Liu W, Li X, Wong YS, Zheng W, Yu Y, Zhang Y, Cao W, Chen T: Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism. ACS Nano 2012, 6(8):6578-6591.
  • Zheng S, Li X, Chen T, Zheng W, Wong YS: PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction.International Journal of Nanomedicine 2012, 7:3939-3949.
  • Li L, Wong YS, Chen T, Fan C, Zheng W: Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers. Dalton Transactions 2012, 41:1138-1141.
  • Luo Y, Li X, Huang X, Wong YS, Chen T, Zhang Y, Zheng W: 1,4-Diselenophene-1,4-diketone triggers caspase-dependent apoptosis in human melanoma A375 cells through induction of mitochondrial dysfunction. Chemical and Pharmaceutical Bulletin 2011, 59:1227-1232.
  • Li Y, Li X, Wong YS, Chen T, Zhang H, Liu C, Zheng W: The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials 2011, 32:9068-9076.
  • Zhang H, Chen T, Jiang J, Wong YS, Yang F, Zheng W: Selenium-containing allophycocyanin purified from selenium-enrich Spirulina platensis attenuates AAPH-induced oxidative stress in human erythrocytes through inhibition of ROS generation. Journal of Agricultural and Food Chemistry 2011, 59:8683-8690.
  • Liu Y, Zhang X, Zhang R, Chen T, Wong YS, Liu J, Zheng WJ: Ruthenium porphyrin complexes induce apoptosis by inhibiting the generation of intracellular reactive oxygen species in the human hepatoma cell line (HepG2).European Journal of Inorganic Chemistry 2011, 2011:1974-1980.
  • Li XL, Chen T, Wong YS, Xu G, Fan RR, Zhao HL, Chan JCN:  Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: an effect attenuated by phycocyanin.The International Journal of Biochemistry & Cell Biology 2011, 43:525-534.
  • Chen T, Mei WJ, Wong YS, Liu J, Liu Y, Xie HS, Zheng WJ: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers.MedChemComm 2010, 1:73-75.
  • Lau WS, Chen T, Wong YS: Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C. Molecular Medicine Report 2010, 3:1023-1030.
  • Chen T, Liu Y, Zheng WJ, Liu J, Wong YS: Ruthenium polypyridyl complexes that induce mitochondria-mediated apoptosis in cancer cells. Inorganic Chemistry 2010, 49:6366-6368.
  • Zheng L, Si J, Wong YS: Ergosterol peroxide and 9,11-dehydroergosterol peroxide from Ganoderma lucidum mycelia suppress the growth of human breast adenocarcinoma MCF-7 cells. International Journal of Medicinal Mushrooms 2009, 11:249-253.
  • Li XL, Xu G, Chen T, Wong YS, Zhao HL, Fang RR, Gu XM, Tong PCT, Chan JCN: Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress modulating JNK and p38 mitogen-activated protein kinase pathways. The International Journal of Biochemistry & Cell Biology 2009, 41:1526-1535.
  • Kong C, Lam C, Chiu L, Ooi VEC, Sun SSM, Wong YS: A rice polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochemical Pharmacology 2009, 77:1487-1496.
  • Chen T, Wong YS: Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. The International Journal of Biochemistry & Cell Biology 2009, 41:666-676.
  • Chen T, Wong YS, Zheng W, Bai Y, Huang L: Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 2008, 67:26-31.
  • Chen T, Wong YS: Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cellular and Molecular Life Sciences 2008, 65:2763-2775.
  • Chen T, Wong YS: In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry 2008, 56:4352–4358.

Research Grants

  • 2010-2012, CUHK Research Committee Direct Grant, Anticancer activities and chemosensitization effects of selenium-containing phycocyanin and its bioactive peptides, $46,443.
  • 2008-2011, National Natural Science Foundation of China (NSFC), 含硒、碲藻藍蛋白的形態分析、抗腫瘤作用及機理研究, RMB 339,000. (Co-I)
  • 2007-2011, Institute of Plant Molecular Biology and Agricultural Biotechnology Research Fund (CUHK-Scheme A), Improvement of micronutrient bioavailability in crops: selenium-enriched rice, $1,200,000.
  • 2002-2005, Research Grants Council-General Research Fund, Isolation and characterization of flavonoid antioxidants in Vigna sinensisseeds, $780,000.
  • 2003-2005, Education Department Quality Education Fund, Multi-school collaboration in the information technology for Hong Kong flora and vegetation, $1,938,000. (Co-I)
  • 2002-2003, Education Department Quality Education Fund, A web-based database and training for Hong Kong flora and vegetation, $1,500,000. (Co-I)
  • 1998-2002, Industry Department Industrial Support Fund, Development of over-the-counter pharmaceutical products based on local medicinal plants. $8,120,000. (Co-I)


  • 螺旋藻藻藍蛋白的酶解產物及其應用,中華人民共和國國家知識產權局(CN101928743A)


  • Certificate of Appreciation, Hong Kong Examinations and Assessment Authority
  • CUHK Science Faculty Exemplary Teaching Award
  • CUHK Biology Society Best Teacher Award

Professional Activities

  • Adjunct Professor, Jinan University, China
  • Founding Member, Hong Kong Food Science and Technology Association
  • Member, Institute of Food Technologists, USA
  • Member, American Society of Plant Biologists
  • Member, Guangdong Botanical Society, China
  • Member, Sigma Xi (The Scientific Research Society, USA)

Community Services

  • Technical Expert, Hong Kong Accreditation Service, Innovation and Technology Commission, HKSAR (since 2012)
  • Chief Examiner, Advanced-Level Biology Subject, Hong Kong Examinations and Assessment Authority (1997-2010)