Professor ZHAI Liting


(Lab): LG 101, Run Run Shaw Science Building

ZHAI Liting


(Lab): (852) 3943 6379


(852) 2603 5745


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2009-2016  PhD, University of Chinese Academy of Sciences
2005-2009   B.Sc, Shan Dong University


2023-       Research Assistant Professor, School of Life Sciences, CUHK 
Postdoctoral Fellow, Stanford University
Postdoctoral Fellow, Hong Kong University of Science and Technology

Research Interests

  • Structure-function study (using X-ray crystallography and Cryo-EM) of the molecular mechanism in bacteria and plant.
  • Structural and functional study of suppressors of free1 in plant.

Representative Publications

(1co-first author; *co-corresponding author)

  1. Maolu Yin, Manizheh Izadi, Karin Tenglin, Thibault Viennet, Liting Zhai, Ge Zheng, Haribabu Arthanari, Laura MK Dassama, Stuart H Orkin. Evolution of nanobodies specific for BCL11A. Proceedings of the National Academy of Sciences. 2023
  2. Fangfang Shen, Ge Zheng, Mekedlawit Setegne, Karin Tenglin, Manizheh Izadi, Henry Xie, Liting Zhai, Stuart H. Orkin*, Laura M. K. Dassama*. A cell-permeant nanobody-based degrader that induces fetal hemoglobin. ACS Central Science.
  3. Liting Zhai, Amber C. Bonds, Hannah Oo, Paula V. Welander*, Laura M. K. Dassama*. Structural insights into bacterial sterol transporter BioRxiv. 2022.
  4. Fengquan Dong; Cang Wu; Weipeng Jiang; Maocai Zhai; Haiying Li*; Liting Zhai*, Xi Zhang*. Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3. Biochemical and Biophysical Research Communications. 2022.
  5. Xi Zhang; Tianzi Wei; Cang Wu; Junyi Jiang; Shengming chend; yinqing Hua; Yi Lu; Dayong Sun*; Liting Zhai*; Jian Zhang*; Chuang Liu*. Cryo-EM structure reveals polymorphic ligand-bound states of IGF1R. Journal of Molecular Biology. 2022.
  6. Xi Zhang, Cang Wu; Zhihong Song; Dayong Sun*; Liting Zhai*; Chuang Liu*. Cryo-EM structures reveal distinct apo conformations of sortilin-related receptor SORLA. Biochemical and Biophysical Research Communications. 2022.
  7. Miaomiao Shen, Nalini Dhingra, Quan Wang, Chen Cheng, Songbiao Zhu, Xiaolin Tian, Jun Yu, Xiaoxin Gong, Xuzhichao Li, Hongwei Zhang, Xin Xu, Liting Zhai, Min Xie, Ying Gao, Haiteng Deng, Yongning He, Hengyao Niu, Xiaolan Zhao, Song Xiang. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nature communications. 2021
  8. Yihui Song1, Liting Zhai1, Jonathan Valencia Swain, Yaqiong Chen, Pengfei Wang, LiChen, YiLiu, Song Xiang*. Structural Insights into the CRTC2–CREB Complex Assembly on CRE. Journal of Molecular Biology. 2018.
  9. Liting Zhai, Lingling Feng, Lin Xia, Huiyong Yin, Song Xiang*. Crystal Structure of Glycogen Debranching Enzyme and Molecular Insights into Its Catalysis and Disease-Causing Mutations. Nature communications. 2016.
  10. Liting Zhai, Song Xiang*. mRNA quality control at the 5' end. Journal of Zhejiang University SCIENCE B. 2014.


  1. Luke BURMAN, Yee Ting CHONG, Yanyan GENG, Leslie Nangle GREENE, Kristina HAMEL, David KING, Ann MENEFEE, Kaitlyn RAUCH, Zhiwen XU, Liting ZHAI, COMPOSITIONS AND METHODS COMPRISING ANTI-NP2 ANTIBODIES, Taiwanese Patent Application No. 108112147. 2019


  • ‘Best Poster’ award entitled ‘Targeting undruggable proteome’ in QBI Bay Area Chemical Biology Symposium, San Francisco, Sep 26-27, 2022.
  • DBC Travel Award and oral presentation of American Chemical Society (ACS) meeting, Chicago, IL, USA, 2022
  • Stanford Bio-X Travel Award. Stanford, CA, USA, 2022
  • Outstanding Paper Award in New World Research scholarship; Shanghai, China, 2016
  • “Zhu Li Yue Hua” Scholarship of Chinese Academy of Sciences; Shanghai, China, 2016
  • Excellent Report Award in 16th Shanghai Structural Biology Conference; Shanghai, China, 2015
  • Merit student of Chinese Academy of Sciences; Shanghai, China, 2010-2014

Professional Activities

  • Guest editor of the Journal of Visualized Experiments (JoVE) (Methods Collection titled “Biochemical and Biophysical Studies of Lipid Transporters).