Professor CHEUNG Chi Keung Peter

Address

(Office): EG09, Science Centre East Block
(Lab): Rm 381, Science Centre South Block

People CCK

Phone

(Office): (852) 3943 6144
(Lab): (852) 3943 6272

Fax

(852) 2603 5646

Email

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Web http://www.cuhk.edu.hk/lifesciences/aboutus/people/CCK.html
   


Education

Ph.D. University of New South Wales
M.Chem. University of New South Wales
B.Sc. The University of Hong Kong


Position

  • Professor, School of Life Sciences
  • Associate Director of Food and Nutritional Sciences Program
  • Director of Food Research Centre
  • Graduate Division Head of Food and Nutritional Sciences Program


Research Interests

  • Structure-function of cell wall polysaccharides
  • Bioactive substances from mushroom and edible fungi
  • Chemical properties and biological functions of dietary fiber
  • Prebiotics, probiotics and gut microbiome


Representative Publications (Past five years)

  1. Chen, L. Xu, W., Lin, S. and Cheung, P.C.K. (2014). Cell wall structure of mushroom sclerotium (Pleurotus tuber regium): Part 1. Fractionation and characterization of soluble cell wall polysaccharides. Food Hydrocolloids, 36, 189-195.
  2. Chen, L., Zhang, B.-B., Chen, J.-L.and Cheung, P.C.K. (2014). Cell wall structure of mushroom sclerotium (Pleurotus tuber regium): Part 2. Fine structure of a novel alkali-soluble hyper-branched cell wall polysaccharide. Food Hydrocolloids, 38, 48-55.
  3. Chen, L. and Cheung, P.C.K. (2014). Mushroom dietary fiber from the fruiting body of Pleurotus tuber-regium: Fractionation and structural elucidation of non-digestible cell wall components. Journal of Agricultural and Food Chemistry, 62, 2891-2899.
  4. Xu, W.W., Li, B., Lai, E.T.C., Chen, L., Huang, J.J.H., Cheung, A.L.M. and Cheung, P.C.K. (2014). Water extract from Pleurotus pulmonarius with antioxidant activity exerts in vivo chemoprophylaxis and chemosensitization for liver cancer. Cancer and Nutrition: An International Journal, 66, 989-998.
  5. Lin, S., Lai, T.C., Chen, L., Kwok, H.F., Lau, C. B-S. and Cheung, P.C.K. (2014) Anti-oxidant and anti-angiogenic properties of phenolic extract from Pleurotus tuber-regium. Journal of Agricultural and Food Chemistry, 62, 9488-9498.
  6. Chen, J., Chen, L., Lin, S., Liu, C. and Cheung P.C.K. (2015). Preparation and structural characterization of a partially depolymerized beta-glucan obtained from Poria cocos sclerotium by ultrasonic treatment. Food Hydrocolloids, 46, 1-9.
  7. Lin, S., Lai, T.C., Chen, J. and Cheung, P.C.K. (2015). Antioxidant and anti-angiogenic effects of mushroom phenolic rich fractions. Journal of Functional Foods, 17, 802-815.
  8. Hu, S.H., Cheung, P.C.K., Hung, R.P., Chen, Y.K., Wang, J.C. and Chang, S.J. (2015). Antitumor and immunomodulating activities of exopolysaccharides produced by big cup culinary-medicinal mushroom Clitocybe maxima (higher Basidiomycetes) in liquid submerged culture. International Journal of Medicinal Mushrooms, 17, 891-901.
  9. Liu, C., Chen, J., Chen, L., Huang, X. and Cheung, P.C.K. (2016). Immunomodulatory activity of polysaccharide-protein complex from the mushroom sclerotia of Polyporus rhinocerus in murine macrophages. Journal of Agricultural and Food Chemistry, 64, 3206-3214.
  10. Lin, S., Lai, T.C., Ke, X. and Cheung, P.C.K. (2016). Comparison of the composition and antioxidant activities of phenolics from the fruiting bodies of cultivated Asian culinary-medicinal mushrooms. International Journal of Medicinal Mushrooms, 18, 871-881. DOI:10.1615/IntJMedMushrooms.v18.i10.30
  11. Chen, L., Cheng, W.N., Zhang, B.B. and Cheung, P.C.K. (2016). Structural and thermal analysis of a hyper-branched exopolysaccharide produced by submerged fermentation of mushroom mycelium. RSC Advances, 6, 112260-112268. 10.1039/C6RA23383J
  12. Huang, J. J., Xu, W., Lin, and Cheung, P.C.K. (2016). Phytochemical profiles of marine phytoplanktons: An evaluation of their in vitro antioxidant and anti-proliferative activities. Food and Function, 7, 5002-5017. DOI: 10.1039/C6FO01033D
  13. Hu, Y., Zhang, B., Xu, G., Liao, X. and Cheung, P.C.K. (2016). A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorate. Journal of Functional Foods, 25, 70-79.
  14. Lin, S., Lai, T.C., Lam, K.L. and Cheung, P.C.K. (2017). Anti-angiogenic effect of water extract from the fruiting body of Agrocybe aegerita. LWT – Food Science and Technology, 75, 155-163. https://doi.org/10.1016/j.lwt.2016.08.044
  15. Keung, H.Y., Li, T.K., Sham, L.T., Cheung, M.K., Cheung, P.C.K. and Kwan, H.S. (2017). Mechanistic study of water insoluble yeast glucans utilization in genetically intractable Bifidobacterium breve strain JCM1192. Applied and Environmental Microbiology, 83, e03442-16. doi: 10.1128/AEM.03442-16
  16. Lin, S., Hu, J., Zhou, X. and Cheung, P.C.K. (2017). Inhibition of VEGF-induced angiogenesis by Chlorogenic acid via targeting the VEGFR2-mediated signaling pathway. Journal of Functional Foods, 32, 285-295. https://doi.org/10.1016/j.jff.2017.03.009
  17. Huang, J.J., Lin, S., Xu, W. and Cheung, P.C.K. (2017). Occurrence and biosynthesis of carotenoids in phytoplankton. Biotechnology Advances, 35, 597-618. http://dx.doi.org/10.1016/j.biotechadv.2017.05.001
  18. Lv, J. Zhang, B.-B. Liu, X.-D., Zhang, C., Chen, L., Xu, G.-R. and Cheung, P.C.K. (2017). Enhanced production of natural yellow pigments from Monascus purpureus by liquid culture: The relationship between fermentation conditions and mycelial morphology. Journal of Bioscience and Bioengineering, 124, 452-458. https://doi.org/10.1016/j.jbiosc.2017.05.010
  19. Hu, S.H., Chen, K.S., Liu, M.Y., Cheung, P.C.K., Wang, J.C. and Chang, S.J. (2017). Optimization of submerged cultivation conditions for production of big cup culinary-medicinal mushroom Clitocybe maxima (Agaricomycetes) biomass with significant antioxidative and antihyperlipidemic activities. International Journal of Medicinal Mushrooms, 19, 641-651. DOI: 10.1615/IntJMedMushrooms.2017021151
  20. Li, X., Zhou, J., Liu, C., Xiong, Q., Duan, H. and Cheung, P.C.K. (2017). Stable and biocompatible mushroom β-glucan modified gold nanorods for cancer photothermal therapy. Journal of Agricultural and Food Chemistry, 65, 9529-9536. http://dx.doi.org/10.1021/acs.jafc.7b03895
  21. Barad,A., Mackedenski, S., Li, W.M., Li, X.J., Lim, B.C.C., Rashid, F., Tackaberry, L.E., Massicotte, H.B., Egger, K.N., Reimer, K., Cheung, P.C.K. and Lee, C.H. (2018). Anti-proliferative activity of a polysaccharide isolated from the basidiomycete fungus Paxillus involutus. Carbohydrate Polymers, 181, 923-930. http://dx.doi.org/10.1016/j.carbpol.2017.11.058
  22. Hu, J., Lin, S., Zeng, S., Zheng, B., Cheung, P.C.K. (2018). Short-chain fatty acids in control of energy metabolism. Critical Reviews in Food Science and Nutrition, 58, 8, 1243-1249. https://doi.org/10.1080/10408398.2016.1245650
  23. Xu, R., Wei, S., Zhou, G., Ren, J., Liu, Z., Tang, S., Cheung, P.C.K. and Wu, X. (2018). Multiplex TaqMan locked nucleic acid real-time PCR for the differential identification of various meat and meat products. Meat Science, 137, 41-46. https://doi.org/10.1016/j.meatsci.2017.11.003
  24. Lam, K.L., Keung, H.Y., Ko, K.C., Kwan, H.S. and Cheung, P.C.K. (2018). In vitro fermentation of beta-glucans and other selected carbohydrates by infant fecal inoculum: An evaluation of their potential as prebiotics in infant formula. Bioactive Carbohydrates and Dietary Fiber, 14, 20-24. https://doi.org/10.1016/j.bcdf.2017.07.009
  25. Yan, J.K., Qiu, W.Y., Wang, Y.Y., Wu, L.X. and Cheung, P.C.K. (2018). Formation and characterization of polyelectrolyte complex synthesized by chitosan and carboxylic curdlan for 5-fluorouracil delivery. International Journal of Biological Macromolecules, 107 Part A, 397-405. https://doi.org/10.1016/j.ijbiomac.2017.09.004
  26. Liu, C., Choi, M.W. Li, X. and Cheung, C.K. (2018). Immunomodulatory effect of structurally-characterized mushroom sclerotial polysaccharides isolated from Polyporus rhinocerus on human monoctyes THP-1. Journal of Functional Foods, 41, 90-99. https://doi.org/10.1016/j.jff.2017.12.039
  27. Li, X., Zhou, J., Dong, X., Cheng, W.Y., Duan, H. and Cheung, P.C.K. (2018). In vitro and in vivo photothermal cancer therapeutic effects of gold nanorods modified with mushroom β–glucan. Journal of Agricultural and Food Chemistry, 66, 4091-4098. DOI: 10.1021/acs.jafc.8b00292
  28. Hu, J., Zhou, A., Cheung, P.C.K., Zheng, B., Zeng, S., Lin, S. (2018). Expression of GPR43 in brown adipogenesis is enhanced by Rosiglitazone and controlled by PPAR?/RXR hetero-dimerization. PPAR Research, in press https://doi.org/10.1155/2018/1051074
  29. Lee, M.K., Li, X., Yap, C.S.A., Cheung, P.C.K., Tan, C.S., Ng, S.T., Roberts, R., Ting, K.N. and Fung, S.Y. (2018). Airway relaxation effects of water-soluble sclerotial extract from Lignosus rhinocerotis. Frontiers in Pharmacology, 9, 461 http://doi.org/10.3389/fphar.2018.00461
  30. Hu, J.; Lin, S.; Huang, J. Cheung, P.C.K. (2018). Mechanistic study of the in vitro and in vivo inhibitory effects of hydroxybenzoic acids (protocatechuic acid and syringic acid) on VEGF-induced angiogenesis. Journal of Agricultural and Food Chemistry 66, 6742-6751. DOI:10.1021/acs.jafc.8b0153
  31. Lam, K.L., Si, K., Wu, X., Tang, S., Sun, X., Kwan, H.S. and Cheung, P.C.K. (2018). The diploid genome of the only sclerotia-forming wide type species in the genus Pleurotus - Pleurotus tuber-regium - provides insights into the mechanism of its biomass conversion from lignocellulose substrates. Journal of Biotechnology, 283, 22-27. https://doi.org/10.1016/j.jbiotec.2018.07.009
  32. Huang, J.J., Lin, S., Xu, W. and Cheung, P.C.K. (2018). Enhancement of the production of bioactive microalgal metabolites by ultraviolet radiation (UVA 365 nm). Journal of Agricultural and Food Chemistry, 66, 10215-10224. DOI: 10.1021/acs.jafc.8b03789
  33. Lam, K.L., Lin, S., Liu, C., Wu, X., Tang, S., Kwan, H.S. and Cheung, P.C.K. (2018). A low-cost method generating in situ anaerobic conditions on a 96-well plate for microbial fermentation in food research. Journal of Agricultural and Food Chemistry, 66, 11839-11845. DOI: 10.1021/acs.jafc.8b04888
  34. Hu, J., Ge, S., Huang, C., Cheung, P.C.K., Lin, L., Zhang, Y., Zheng, B. and Lin, S. (2018). Tenderization effect of whelk meat using ultrasonic treatment. Food Science and Nutrition, 6, 1848-1857. DOI: 10.1002/fsn3.686
  35. Ke, X., Walker, A., Haange, S.-B., Lagkouvardos, I., Liu, Y., Schmitt-Kopplin, P., von Bergen, M., Jehmlich, N., He, X., Clavel, T., and Cheung, P.C.K. (2019). Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice. Molecular Metabolism, 22, 96-109.10.1016/j.molmet.2019.01.012
  36. Lam, K.L., Ko, K.C., Li, X., Ke, X., Cheng, W.Y., Chen, T.F., You, L., Kwan, H.S. and Cheung, P.C.K. (2019). In vitro infant fecal fermentation of low viscosity barley beta-glucan and its acid hydrolyzed derivatives: Evaluation of their potential as novel prebiotics. Molecules, 24, 828. https://doi.org/10.3390/molecules24050828
  37. Huang, S., Pang, D., Li, X., You, L., Zhao, Z., Cheung, P.C.K., Zhang, M. and Liu, D. (2019). A sulfated polysaccharide from Gracilaria lemaneiformis regulate cholesterol and bile acid metabolism in high-fat diet mice. Food and Function, 10, 3224-3236. 10.1039/C9FO00263
  38. Chen, X., Li, X., Zhang, X., You, L., Cheung, P.C.K., Huang, R. and Xiao, J. (2019). Antihyperglycemic and antihyperlipidemic activities of a polysaccharide from Physalis pubescens in streptozotocin (STZ)-induced diabetic mice. Food and Function, 10, 4868-4876. 10.1039/C9FO00687G
  39. Chen, L., Ge, M., Zhu, Y., Song, Y., Cheung, P.C.K., Zhang, B., Liu, L. (2019). Structure, bioactivity and applications of natural hyperbranched polysaccharides. Carbohydrate Polymers, 223, 115076. https://doi.org/10.1016/j.carbpol.2019.115076
  40. Liu, C. and Cheung, P.C.K. (2019).Structure and immunomodulatory activity of microparticulate mushroom sclerotial β-glucan prepared from Polyporus rhinocerus. Journal of Agricultural and Food Chemistry, 67, 9070-9078. https://doi.org/10.1021/acs.jafc.9b03206
  41. Tang, H.M. and Cheung, P.C.K. (2019). Gallic acid triggers iron-dependent cell death with apoptotic, ferroptotic, and necroptotic features. Toxins, 11, 492. doi:10.3390/toxins11090492
  42. Javed, S., Li, W.M., Yaqoob, A., Zeb, M., Tackaberry, L., Massicotte, H., Egger, K., Cheung, P.C.K., Payne, G. and Lee, C.H. (2019). Anti-inflammatory activity of the wild mushroom, Echinodontium tinctorium, in RAW264.7 macrophage cells and mouse microcirculation. Molecules, 24, 9 DOI: 10.3390/molecules24193509
  43. Liu, C., Choi, M.W. and Cheung, P.C.K. (2019). Immunomodulatory effect of structurally-characterized mushroom sclerotial polysaccharides isolated from Polyporus rhinocerus on bone marrow dendritic cells (BMDCs). Journal of Agricultural and Food Chemistry, https://doi.org/10.1021/acs.jafc.9b03294
  44. Lam, K.L. and Cheung, P.C.K. (2019). Carbohydrate-based prebiotics in targeted modulation of gut microbiome. Journal of Agricultural and Food Chemistry, http://dx.doi.org/10.1021/acs.jafc.9b04811.


Research Grants
 

  • 2020-2024, Theme-based Research (TBR), A paradigm-shifting, fully-integrated, compact wastewater-to-resource facility – Chemical and biological properties of sulfated polysaccharides recovered from sludge. $1,646,000
  • 2019-2024, Research Impact Fund (GIF), Tackling grand challenges in food safety: A bug data and IoT enabled approach $ 790160
  • 2018-2020, General Research Fund (GRF), Post-transcriptional modification of early stages of fruiting body development and alternate destinies of the model mushroom Coprinopsis cinerea.$ 817,190
  • 2015-2016, General Research Fund (GRF), In vitro bifidogenicity of prebiotic mushroom beta-glucan and its effect on human gut microbiota: A mechanistic study using transcriptomics, fractional proteomics and 16S rDNA sequences. $844,130
  • 2013-2014, General Research Fund (GRF), A comparative study of the in vitro immunomodulating effects of structurally well-defined purified mushroom and fungal beta-glucans in human immune cells. $542,136
  • 2011-2012, General Research Fund (GRF), Ultrasonication-induced changes in the higher order structures of high molecular weight polysaccharides from medicinal fungi and their relationship to immunoactivity, $710,000
  • 2009-2011, General Research Fund (GRF), Controlled degradation of high molecular weight polysaccharides from a medicinal fungus by ultrasonication for improvement of medicinal properties, $620,000
  • 2006-2009, National Natural Science Foundation of China (NSFC), The effect of molecular dimension and solution conformation of mushroom polysaccharides with their biological activities and mechanisms, $1,300,000
  • 2005-2007, Research Grants Council (RGC) Earmarked Grants, Mushroom non-digestible carbohydrates as novel β-glucan type prebiotics: Their preparation and in vitromicrobial fermentation, $ 718,957
  • 2002-2004, Research Grants Council (RGC) Earmarked Grants, A mechanistic study of the immunopotentiating and antitumor effects of native and chemically modified nonstarch polysaccharides [(1®3)-b-D-glucans] from mushroom sclerotia, $1,036,000
  • 2002-2004, Research Grants Council (RGC) Earmarked Grants, In vitro and in vivoanticancer studies of novel polyunsaturated fatty acids (DHA, EPA) purified and characterized from several enriched microalgae, $876,000
  • 2002-2004, University Grants Council Area of Excellence (AoE) in Plant and Fungal Biotechnology, Immunopharmacological activities of native and chemically modified mushroom non-starch polysaccharides $500,000
  • 2000-2002, University Grants Council Area of Excellence (AoE) in Plant and Fungal Biotechnology, Isolation, characterization, bioassay and functional tests of mushroom polysaccharides with anti-tumor and immuno-potentiating activities, $700,000
  • 1999-2001, Research Grants Council (RGC) Earmarked Grants, Correlation between antitumor activities and structural characteristics of mushroom polysaccharides $580,000
  • 1999-2004, Strategic Grant of the Chinese University of Hong Kong, Pharmaceutical, nutritional and biotechnological application of seaweed resources in Hong Kong $600,000
  • 1996-1998, Research Grants Council (RGC) Earmarked Grants, Characterization of pharmacologically active substances and nutritional evaluation of selected seaweeds in Hong Kong, $500,000


Patents

  • The preparation and application of a water-soluble heteropolysaccharide [一種水溶性雜多糖及其制備方法和用途]. Chinese Patent CN 1425693A (published on 25 June 2003)
  • The preparation and application of an antitumor water-soluble heteropolysaccharide [一種具有抗腫瘤活性的水溶性雜多糖及其製備方法和用途]. Chinese Patent CN 1425694A (published on 25 June 2003)
  • Extract of a medicinal mushroom, Polyporus rhinocerusCooke and composition of the same having antiproliferation of cancer cells and immune enhancing activity[具有抗癌與免疫增强活性的虎乳灵芝提取物及其制備方法]. Chinese Patent CN 200510114299.4 (published on 5 February 2010)
  • Extraction of Polyporus rhinocerus Cooke with antitumor and immune-enhancing activities and preparation thereof [具有抗癌與免疫增强活性的虎乳灵芝提取物及其制備方法]. Hong Kong SAR Patent HK1101770 (published on 21 January 2011)


Professional Activities

Editorial membership

  • Associate Editor of the Bioactive Carbohydrates and Dietary Fibre
  • Member of the Advisory Board of Journal of Agricultural and Food Chemistry
  • Member of the Editorial Board of International Journal of Medicinal Mushrooms
  • Editorial Board of the International Society for Medicinal Mushrooms Newsletter
  • Member of the Editorial Board of Food Science (Shipin Kexue)

Professional membership

  • Member of the Institute of Food Technologists (IFT)
  • Member of the American Chemical Society (ACS)
  • Professional Member of the Australian Institute of Food Science and Technology (MAIFST)
  • Chartered Chemist (Australia) (CChem)
  • Member of the Royal Australian Chemical Institute (MRACI)

Professional services

  • Served as Vice-chairman of the International Food Safety Association (since 2011)
  • Served as the Expert Panel member (Food Science and Nutrition) of the Hong Kong Food Science and Technology Association (since 2011)
  • Served as the Advisor of the Hong Kong Nutrition Association (since 2010)
  • Served as the Advisor of the Hong Kong Public Health Inspector Association (since 2009)
  • Served as the Chairman of the Hong Kong Food Science and Technology Association (2004-2005).
  • Served as the Vice-chairman of the Hong Kong Food Science and Technology Association (1997-2003).


Others

Community and Educational Services

  • Appointed as Specialist of the Hong Kong Council for Accreditation of Academic and Vocational Qualifications (HKCAAVQ) (2016-2019)
  • Chairperson of the Internal Validation Panel for the Bachelor of Science (Hons) in Food Science and Safety of the Technological and Higher Education Institute of Hong Kong (THEi) (since 2014)
  • External Academic Adviser and Examination Paper Moderator of the HKBU College of International Education on Associate Degree of Food Safety and Environmental Health (since 2014)
  • External Member of the Internal Validation Panel for BA (Hons) in Chinese Culinary Management with Design of the Technological and Higher Education Institute of Hong Kong (THEi) (since 2012)
  • External Examiner of the Professional Diploma in Waste Management and Meat and Foods Inspection for Food and Environmental Hygiene Department of the Li Ka Shing Institute of Professional and Continuing Education (since 2008)
  • External Examiner of the Hospitality Industry Training and Development Centre (HITDC) and Chinese Cuisine Training Institute (CCTI) of the Vocational Training Council (VTC) (since 2008)
  • Member of the Curriculum Development Council (CDC) and Hong Kong Examinations and Assessment Authority (HKEAA) Committee on Technology and Living (senior Secondary), Education Bureau of the HKSAR Government (since 2008)
  • Appointed as Moderator of the Technology and Living (Food Science and Technology) Papers 1 & 2 (E & C) (Practice Paper) of the Hong Kong Examinations and Assessment Authority (2010-2015)
  • Appointed as member of the Expert Committee on Food Safety, Food and Health Bureau, Government Secretariat of the HKSAR Government (2008-2010)