Professor SHAW Pang Chui


(Office): Rm 180, Science Centre South Block
(Lab): Rm 195, Science Centre South Block

People PCS


(Office): (852) 3943 1363 , 39436803
(Lab): (852) 3943 8027

Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.



1987 Ph.D. Imperial College, University of London
1983 M.Phil.. The Chinese University of Hong Kong
1981 B.Sc. The Chinese University of Hong Kong


  • Professor, School of Life Sciences
  • Director, Biochemistry Programme
  • Director, Centre for Protein Science and Crystallography
  • Deputy Director, Institute of Chinese Medicine
  • Master, Postgraduate Halls


Research Interests

  • Structure-function studies of proteins
  • Authentication and quality control of Chinese Medicinal material 

Representative Publications

  • Ng, Y.M., Yang, Y.H., Sze, K.H., Zhang, X., Zheng, Y.T. and Shaw, P.C. (2011) Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa cylindrical). J. Str. Biol. 174: 164-172.
  • Li, M., Cao, H., But, P.P.H. and Shaw, P.C. (2011) Identification of herbal medicinal materials using DNA barcodes. J. System. Evol. 49: 271-283.
  • Law, S.K., Simmons, M.P., Techen, N., Khan, I.A., He, M.F., Shaw, P.C. and But, P.P.H. (2011) Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook f.). Phytochemistry 72: 21-26.
  • Su, C., Wong, K.L., But, P.P.H., Su W.W. and Shaw P.C. (2010) Molecular authentication of the Chinese herb Huajuhong and related medicinal material by DNA sequencing and ISSR markers. J. Food Drug Anal. 18: 161-170.
  • Lou S.K., Wong, K.L., Li, M., But, P.P.H. and Shaw, P.C. (2010) An integrated web medicinal materials DNA database: MMDBD (Medicinal materials DNA barcode database). BMC Genomics 11: 402.
  • Law, S.K.Y., Wang, R.R., Mak, A.N.S., Wong, K.B., Zheng, Y.T. and Shaw, P.C. (2010) A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells. Nucl. Acids Res. 38: 6803-6812.
  • Chan, W.H., Ng, A.K., Robb, N.C., Lam, M.K., Chan, P.K., Au, S.W., Wang, J.H., Fodor, E. and Shaw, P.C. (2010) Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol. 84: 7337-7345.
  • Too, P.H.M., Ma, M.K.W., Mak, A.N.S., Wong, Y.T., Tung, C.K.C., Zhu, G., Au, S.W.N., Wong, K.B. and Shaw, P.C. (2009) The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome. Nucl. Acids Res. 37: 602-610.
  • Ng, A.K.L., Zhang, H., Tan, K., Li, Z., Liu, J.H., Chan, P.K.S., Li, S.M., Chan, W.Y., Au, S.W.N., Joachimiak, A., Walz, T., Wang, J. and Shaw, P.C. (2008) Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization and vaccine design. FASEB J. 22: 3638-3647.
  • Mak, A.N.S., Wong, Y.T., An, Y.J., Cha, S.S., Sze, K.H., Au, S.W.N., Wong, K.B. and Shaw, P.C. (2007) Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site. Nucl. Acids Res. 35: 6259-6267.

Research Grants

  • 2011-2012, General Research Fund of Research Grants Council, Structural study and characterization of influenza b virus nucleoprotein, HK$1,111, 612
  • 2011-2013, Research Fund for the Control of Infectious Diseases, Modified maize ribosome-inactivating proteins as possible anti-HIV agent by the SIV-infected rhesus macaque model HK$999,240
  • 2010-2011,中國科學院大科學裝置開放研究項目, 中國涼茶藥用植物的DNA條形碼研究, RMB$100,000
  • 2010-2012, Research Fund for the Control of Infectious Diseases, In silico structure-based screening and characterization of inhibitors for influenza A virus nucleoprotein and RNA polymerase, $996,520
  • 2009-2011, General Research Fund of Research Grants Council, The refinement of the influenza virus H5N1 nucleoprotein structure and the structure-function study of its oligomerization and interaction with RNA, $930,246
  • 2008-2011, The Croucher Foundation, Advanced Study Institute on ‘Structure based screening and design of ligands for protein targets, HK$600,000


  • But, P.P.H., Xu, Y.T., Shaw, P.C., Jiang, R.W. and Hon, P.M. (2011) Method of making antitussive medicine and relieving cough. US Patent No. 7,867,998.
  • Shaw, P.C., Wang, J., But, P.P.H., Lau, T.W. (2004) The DNA sequences of medicinal Dendrobium and the application of these sequences for species identification and authentication. Chinese Patent ZL 01 1 02434.8.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2003) Application of RFLP of DNA for the authentication of Chinese medicinal material. Chinese patent 98100001.0.
  • Shaw, P.C., Wang, J., But, P.P.H., Ha, W.Y., Yau, F.C.F. (2004) Sequence characterized amplified region (SCAR) test for the authentication of traditional Chinese medicinal materials. US Patent No. 6,803,215.
  • Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2001) Polymerase chain reaction-restriction fragment length polymorphism test for the authentication of herbal Chinese medicines. U.S. Patent No. 6,309,840.

Professional Activities

  • Associate Editor, Chinese Medicine
  • Editorial Board, Protein Engineering, Design and Selection
  • Visiting professor, Sun Yat-sen University
  • Vice-chairman, Hong Kong Bioethics Association
  • Council member, Chinese Crystallographic Society, China
  • Council member, Chinese Genetics Society, China