Professor LAU Kwok Fai

Address

(Office): Rm 291, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People LKF 

Phone

(Office): (852) 3943 1106
(Lab): (852) 3943 6119
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
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Education

1999 Ph.D., Chinese University of Hong Kong
1994 M.Phil., Chinese University of Hong Kong
1992 B.Sc., Hong Kong Baptist University


Position

  • Professor, School of Life Sciences
  • Program Director, MSc Programme in Biochemical and Biomedical Sciences, CUHK


Research Interests

  • Amyloid precursor protein interacting proteins in Alzheimer’s disease and neurodegenerative disorders
  • Amyloid precursor protein and its interacting proteins in neurodevelopment 
  • Protein Kinases in neurodegenerative disorders


Representative Publications

  • Chan WWR, Chow J, Chau DDL, Zhai Y and Lau KF (2025) Beclin 1-mediated autophagy is potentiated by an interaction with the neuronal adaptor FE65. Biology 14(1):97. https://doi.org/10.3390/biology14010097
  • Ng LL, Chow J and Lau KF (2024) The AICD interactome: implications in neurodevelopment and neurodegeneration. Biochem Soc Trans. 52(6):2539-2556. doi: 10.1042/BST20241510
  • Chau, DDL., Yu, Z, Chan, WWR, Zhai Y, Chang RCC, Ngo JCK, Chan HYE and Lau KF (2024) The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing. Cell. Mol. Life Sci. 81, 323.
  • Chau DD, Ng LLH, Zhai Y and Lau KF (2023) Amyloid precursor protein and its interacting proteins in neurodevelopment. Biochem Soc Trans 51(4), 1647-1659.
  • Iyaswamy A, Thakur A, Guan X, Fung T, Krishnamoorthi S, Gaurav I, Wang X, Yang Z, Lau KF, Wong M, Zhang K, Lian Q, NG R, Chen HJ and Li M (2023) Fe65 engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathogenesis of Alzheimer’s disease. Signal Transduction and Targeted Therapy 8(1):404.
  • Zhai Y, Leung KT and Lau KF (2023) Regulation of cytohesins by their interactors. Neural Regen Res 18 (10) 2186-2187.
  • Chau DDL, Li W, Chan WWR, Sun JKI, Zhai Y, Chow HM and Lau KF (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signalling. FASEB J. 36, e22594
  • Zhai Y, Chan WWR, Li W and Lau KF (2022) ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth. Open Biol (The Royal Society) 12, 220071.
  • Chan WWR, Li W, Chang RCC, and Lau KF (2020) ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1. FASEB J. 34, 16397-16413.
  • Chan WWR, Chau DLD, Li W and Lau KF (2019) Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1. Bio-protocol 9(23): e3449. DOI: 10.21769/BioProtoc.3449.
  • Chau DDL, Yung KWY, Chan WWL, An Y, Hao Y, Chan HYE, Ngo JCK and Lau KF (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035
  • Chan WW, Li W, Chau D L and Lau KF (2019) An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons. J Vis Exp. (152), e60031, doi:10.3791/60031
  • Li W, Chan, Chan WWR, Ngo JCK and Lau KF (2018) Emerging roles of neural adaptor FE65 in neurite outgrowth. Neural Regen Res. 13, 2085-2086.
  • Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE and Lau KF (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 293, 7674-7688.
  • Lee YS, Chow WNV and Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Scientific Reports 7(1):12456. doi: 10.1038/s41598-017-12334-2.
  • Chiu WY, Koon A, Ngo JCK, Chan HYE and Lau KF (2017) GULP1/CED-6 ameliorates Amyloid-β toxicity in a Drosophila model of Alzheimer's disease. Oncotarget 8, 99274-99283. doi.org/10.18632/oncotarget.20062.
  • Lee CW, Stankowski, JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW and Petrucelli L (2017) The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration 12(1):55. doi: 10.1186/s13024-017-0196-6.
  • Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
  • Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
  • Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
  • Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
  • Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
  • Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
  • Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
  • Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
  • Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
  • Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
  • Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.


Research Grants

  • 2022-2025 Collaborative Research Equipment Grant (Co-PI)
  • 2021-2024 Health and Medical Research Fund (PI)
  • 2020-2023 RGC General Research Fund (Co-I)
  • 2019-2021 RGC General Research Fund (PI)
  • 2016-2018 Health and Medical Research Fund (PI)
  • 2015-2017 Health and Medical Research Fund (Co-I)
  • 2015-2017 RGC General Research Fund (Co-I)
  • 2014-2016 Health and Medical Research Fund (PI)
  • 2013-2015 RGC General Research Fund (PI)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2014 Research Fund for the Control of Infectious Diseases (Co-I)
  • 2012-2014 RGC General Research Fund (Co-I)
  • 2011-2013 RGC General Research Fund (PI)
  • 2007-2010 RGC General Research Fund (PI)
  • 2005-2009 Motor Neurone Disease Association UK

 
Awards

  • Science Faculty Exemplary Teaching Award 2013/2014; 2018/2019
  • Croucher Foundation Fellowship 1999-2001

Professional Activities

  • Associate Editor: Frontiers in Molecular Neuroscience
  • Editorial board member: International Journal of Brain Science; SOJ Biochemistry, International Journal of Neurology Research; American Journal of Psychiatry and Neuroscience