Professor LAU Kwok Fai

Address

(Office): Rm 291, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People LKF 

Phone

(Office): (852) 3943 1106
(Lab): (852) 3943 6119
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
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Education

1999 Ph.D., Chinese University of Hong Kong
1994 M.Phil., Chinese University of Hong Kong
1992 B.Sc., Hong Kong Baptist University


Position

  • Associate Professor, School of Life Sciences


Research Interests

  • The roles of the amyloid precursor protein (APP) interacting proteins in Alzheimer's disease
  • The role of APP in gene regulation
  • Molecular pathogenesis of neurodegeneration


Representative Publications

  • Chau DDL, Yung KWY, Chan WWL, An Y, Hao Y, Chan HYE, Ngo JCK and Lau KF (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J 33, 12019-12035 
  • Chan WW, Li W, Chau D L and  Lau K F (2019) An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons. J. Vis. Exp. (152), e60031, doi:10.3791/60031 
  • Li W, Chan, Chan WWR, Ngo JCK and Lau KF (2018) Emerging roles of neural adaptor FE65 in neurite outgrowth. Neural Regen Res 13, 2085-2086.
  • Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE and Lau KF (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 293, 7674-7688.
  • Lee YS, Chow WNV and Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Scientific Reports 7(1):12456. doi: 10.1038/s41598-017-12334-2.
  • Chiu WY, Koon A, Ngo JCK, Chan HYE and Lau KF (2017) GULP1/CED-6 ameliorates Amyloid-β toxicity in a Drosophila model of Alzheimer's disease. Oncotarget 8, 99274-99283. doi.org/10.18632/oncotarget.20062.
  • Lee CW, Stankowski, JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW and Petrucelli L (2017) The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration 12(1):55. doi: 10.1186/s13024-017-0196-6.
  • Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
  • Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
  • Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
  • Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
  • Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
  • Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
  • Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
  • Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
  • Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
  • Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
  • Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.


Research Grants

  • Principal Investigator, Investigate the role of protein kinase C zeta in regulating GULP1-mediated APP metabolism (03140086), HMRF, 28/07/2016 - 27/07/2018, HK$1,122,468
  • 2014-2016, HMRF, Investigation on FE65 Serine-610 Phosphorylation and Its Functional Implications in Alzheimer’s Disease Amyloid Precursor Protein Processing, HK$977,640
  • 2013-2015, GRF, ARF6, a novel FE65 ligand: Role in FE65-Mediated Amyloid Precursor Protein Trafficking and Processing, HK$750,000
  • 2013-2014, RFCID, Generation of PE-PPE interactome of M. tuberculosis, HK$ 988,880 (as Co-I; PI, Prof AU Shannon)
  • 2012-2014, GRF, A novel labeling of proteins via peptide-peptide binding induced covalent cross-linking, $710,000 (as Co-I; PI, Prof XIA Jiang)
  • 2011-2013, GRF, GULP, a novel Alzheimer's disease amyloid precursor protein (APP) interacting protein: roles in APP processing and intracellular signaling, $524,542
  • 2007-2010, GRF, AGS1, a new Fe65 binding protein: roles in Alzheimer's disease amyloid precursor protein processing and intracellular signaling, $984,259  

 
Awards

  • Science Faculty Exemplary Teaching Award 2013/2014
  • Croucher Foundation Fellowship 1999-2001