Professor TSANG Suk Ying Faye

Address

(Office): Rm 607, Mong Man Wai Building

(Lab): Rm 612B, Mong Man Wai Building

People TSY
 

Phone

(Office): (852) 3943 1020

(Lab): (852) 3943 8071

Fax (852) 2603 7732
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Web -
 

 

Education

2003 Ph.D. Chinese University of Hong Kong
1999 B.Sc. Chinese University of Hong Kong (1st class honor)

Position

  • Associate Professor, School of Life Sciences
  • Investigator, State Key Laboratory in Agrobiotechnology
  • Investigator, Ministry of Education (MOE) Key Laboratories for Regenerative Medicine
  • Investigator, Institute for Tissue Engineering and Regenerative Medicine (iTERM), CUHK
  • Program Director, Food and Nutritional Sciences Program. CUHK

Research Interests

1. Embryonic stem cells and their cardiac derivatives:

a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.

b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.

c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.

2. Ion channels and cardiovascular physiology.

3. Adult stem cells and cancer stem cells.

Representative Publications

  • Liu X, Zhao R, Ding Q, Yao X, Tsang SY (2021) TRPC7 regulates the electrophysiological functions and structures of embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther. 12(1):262.
  • Zhao R, Liu X, Qi Z, Yao X, Tsang SY (2021) TRPV1 channels regulate the automaticity of embryonic stem cells-derived cardiomyocytes through stimulating the Na+/Ca2+ exchanger current. J Cell Physiol. Online ahead of print.
  • Chan HC, Lau YT, Ding Q, Li CK, Wong CM, Shaw PC, Waye MMY, Tsang SY (2020) PinX1t, a novel PinX1 transcript variant, positively regulates cardiogenesis of embryonic stem cells. J Am Heart Assoc. 9:e010240.  
  • Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL, Tsang SY (2020). Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. 235:6794-6807.
  • Qi Z, Chen M, Song Y, Wang X, Chen ZF, Tsang SY *, and Cai Z* (2019) Acute exposure to Triphenyl Phosphate (TPHP) inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish. J Cell Physiol. 234(11):21235-21248.
  • Wang Y, Qi YX, Qi Z, Tsang SY (2019) TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3/RASA4/MAPK pathway. Cancers. 11:558. 
  • Xu Y, So C, Lam HM, Fung MC, Tsang SY (2018) Apoptosis reversal promotes cancer stem-like cell formation. Neoplasia. 20:295-303.
  • Zhao R, and Tsang SY (2017) Versatile roles of intracellularly located TRPV1 channel. J Cell Physiol. 232:1957-65.
  • Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2016). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. 203:169-81.
  • Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY (2016) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 231:403-13.
  • Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.
  • Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol. 168:3458-72.
  • Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res. 97:520-32.
  • Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)
  • Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)
  • Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111:11-20.
  • Tsang SY, Lesso H, Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem 279:43752-9.
  • Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I, Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44:1-5.
  • Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M, Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35:1709-14.


Research Grants

  • 2021-2023, GRF, Role of TRPA1 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes through mediating mitochondrial biogenesis and/or dynamics, HKD $ 996,285
  • 2018-2020, GRF, The role of TRPC7 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes, HKD $ 854,494
  • 2017-2019, GRF, The role of TRPV1 channels in regulating the functions of embryonic stem cell-derived cardiomyocytes, HKD $ 893,792
  • 2014-2016, GRF, The role of Angiotensin II and the underlying mechanisms in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 744,788
  • 2013-2014, RGC Germany/Hong Kong Joint Research Scheme, Role of transient receptor potential (TRP) channels in mediating cardiotrophin-1-induced cardiac differentiation in embryonic stem cells, HKD $ 28,600
  • 2013-2014, GRF, The role of TRPC3 in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 650,000
  • 2012-2013, RGC Germany/Hong Kong Joint Research Scheme, Effects of Inflammatory Cytokines on the Cardiac Differentiation of Embryonic Stem Cells: Role of Reactive Oxygen Species, HKD$ 59,200
  • 2011-2014, GRF, Characterization of PinX1 and a novel truncated form of PinX1: their role in maintaining the characteristics of embryonic stem cells, HK$ 752,321
  • 2007-2011, GRF, Directed differentiation of human embryonic stem cells into cardiac lineage and the molecular mechanisms involved, HK$ 1,136,464
  • 2004-2006, Croucher Foundation, Genetic engineering of human embryonic stem cells to create a self-renewable ex vivo library of “custom-tailored” heart cells for transplantation, US$ 71,728


Awards

  • 2017, The Faculty Exemplary Teaching Award, CUHK

  • 2004-2006, The Croucher Foundation Fellowship

 

Professional Activities

 

Activities for Science Promotion