Crystal structure of UreG/UreF/UreH Complex

Prof. Kam-bo Wong’s research group at the School of Life Sciences recently discovered a novel mechanism how nickel ion is delivered to the active site of urease, an enzyme essential for the survival of Helicobactor pylori in acidic stomach. Prof Wong’s research findings have been published in PLoS Biology, the top ranking journal in biology, and recommended by Faculty of 1000.  In his recommendation to F1000, Prof. Rainer Haas wrote “The results … can explain the complex protein interactions required for urease maturation … also highlight an intriguing mechanism how bacterial cells are able to manage both the tight regulation of transition metal availability and selective incorporation of the appropriate metals into metalloproteins



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