Prof. Kam-Bo Wong published a PNAS paper on how Helicobacter pylori delivers a toxic metal to the urease to keep alive in human stomach

Prof. Kam-Bo Wong’s research group at the School of Life Sciences uncovered how Helicobacter pylori solves the problem of delivering a toxic metal, nickel, to the active site of urease, an enzyme essential for the infection of the pathogen in acidic human stomach. The discovery helps future development of novel drugs against H. pylori infection. Their research findings were published in the Proceedings of the National Academy of Sciences of the USA in December 2017. (Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation.

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