Education

Current Positions

• Associate Professor, School of Life Sciences, CUHK

Research Interests

• Genomics and bioinformatics
• Systems biology
• Plant stress response
• Plant secondary metabolism and trichome function

Representative Publications

• Jiawei Wu and Dianjing Guo. Understanding dosage effects of traditional Chinese medicine using network analysis. Frontiers in pharmacology. May 2025. DOI:10.3389/fphar.2025.1534129

• Jiawei Wu and Dianjing Guo. Systematic analysis of traditional Chinese medicine prescriptions provides new insights into drug combination therapy for pox. Journal of Ethnopharmacology. Volume 337, Part 1, 30 January 2025, 118842

• Chao Wu and Dianjing Guo. Computational Docking Reveals Co-Evolution of C4 Carbon Delivery Enzymes in Diverse Plants. Int J Mol Sci. 2022. 21;23(20):12688. doi: 10.3390/ijms232012688

• Y Huang, L Zhou, C Hou, D. GUO. The dynamic proteome in Arabidopsis thaliana early embryogenesis. Development. 2022 Sep 15;149(18).

• L Zhou, Y Huang, Q Wang, D. GUO. AaHY5 ChIP-seq based on transient expression system reveals the role of AaWRKY14 in artemisinin biosynthetic gene regulation. Plant Physiology and Biochemistry. 2021, Vol. 168

• L Zhou, Y Huang, Q Wang, D Guo. Chromatin Accessibility Is Associated with Artemisinin Biosynthesis Regulation in Artemisia annua. Molecules 2021, 26(4), 1194; https://doi.org/10.3390/molecules26041194

• Y Wei, L Zhou, Y Huang, D Guo. Integrated Dissection of lncRNA-Perturbated Triplets Reveals Novel Prognostic Signatures Across Cancer Types. Int J Mol Sci 2020 Aug 24;21(17):6087.

• Yan Zhang and Dianjing Guo. Epigenetic Variation Analysis Leads to Biomarker Discovery in Gastric Adenocarcinoma. Genet . 2020 Dec 8;11:551787. doi: 10.3389/fgene.2020.551787. eCollection 2020.

• Dai Weixing and Dianjing GUO. A Ligand-Based Virtual Screening Method Using Direct Quantification of Generalization Ability. Molecules. 2019 Jun 30;24(13). pii: E2414. doi: 10.3390/molecules24132414.

• Dai Weixing and Dianjing GUO. Beta Distribution-Based Cross-Entropy for Feature Selection. Entropy 2019, 21(8), 769; https://doi.org/10.3390/e21080769
  Received: 15 June 2019 / Revised: 30 July 2019 / Accepted: 5 August 2019 / Published: 7 August 2019

• Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo, Yejun Wang. LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features. BMC Cancer MS ID: BCAN-D-18-02726R2

• Mehedi Hasan ^, Shamima Khatun and Guo Dianjing   NTyroSite: Computational Identification of Protein Nitrotyrosine Sites Using Sequence Evolutionary Features Molecules 2018, 23(7), 1667; https://doi.org/10.3390/molecules23071667

• Hydrogen peroxide facilitates Arabidopsis seedling establishment by interacting with light signalling pathway in the dark. Han Cheng, Qun Liang, Xiang Chen , Yuanyuan Zhang, Fei Qiao and Dianjing Guo. Plant, cell and environment (cover story). 26 November 2018

• Mehedi Hasan, Dianjing Guo  and  Hiroyuki Kurata. Computational identification of protein S-sulfenylation sites by incorporating the multiple sequence features information. Molecular Biosystems, 2017, 12

• Jia Wen, Jue Wang, Qing Zhang, and Dianjing Guo. A heuristic model for computational prediction of human branch point sequence. BMC bioinformatics. 2017,18:459.

• Ming-an SUN, Yejun WANG, Qing ZHANG, Yiji XIA,Wei GE, and Dianjing GUO. Prediction of reversible disulfide based on features from local structural signatures. BMC Genomics. 2017.18(279). doi:  10.1186/s12864-017-3668-8.

• Qing Zhang, Xiaodan Fan, Yejun Wang, Mingan Sun, Jianlin Shao, Dianjing Guo. BPP: a sequence-based algorithm for branch point prediction. 2017. Bioinformatics. Volume 33, Issue 20, 2017, Pages 3166–3172.

• Md. Mehedi Hasan, Mst. Shamima Khatun, Md. Nurul Haque Mollah, Cao Yong, and Guo Dianjing. A systematic identification of species-specific protein succinylation sites using joint element features information. 2017. Journal of Nanomedicine. Volume 12: Pages 6303-6315.

• Ming-an SUN, Yejun WANG, Qing ZHANG, Yiji XIA,Wei GE, and Dianjing GUO. Prediction of reversible disulfide based on features from local structural signatures. BMC Genomics. 2017.18(279). doi:  10.1186/s12864-017-3668-8.

• Ling Fu, Keke Liu, Mingan Sun, Caiping Tian, Rui Sun, Carlos Morales Betanzos, Keri A. Tallman, Ned A. Porter, Yong Yang,Dianjing Guo, Daniel C. Liebler and Jing Yang. Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity with Cysteines Across Human Proteomes. Molecular & Cellular Proteomics. 2017. 16,1815-1828.

• Mingan Sun, Qing Zhang, Yejun Wang, Wei Ge, and Dianjing Guo.Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features. 2016. BMC Bioinformatics, DOI: 10.1186/s12859-016-1185-4.

Research Grants

• 2020-2023. Study on the mechanism of action and safety of artemisinin-piperaquine tablets in the treatment of mild or moderate COVID-19. RMB 1,000,00

• 2012-2015. CRF. Genomic and molecular studies of a salinity tolerance locus in the wild soybean genome. Hong Kong HK$8,035,050 (as co-I, PI: Prof. Hon-ming Lam)

• 2010-2013. GRF, Probing the molecular function of a bHLH protein in A.annua glandular trichome morphogenesis. HK$1,150,000

• 2010-2012. CRF. Identification of Redox-sensitive Proteins and Characterization of Their Functions in Regulating the Oxidative Stress Response in Arabidopsis. HK$5,000,000. (as co-I, PI: Prof. Yiji Xia, HKBapU)

• 2009-2012. GRF, Roles of two regulatory proteins in artemisinin metabolism and trichome function. HK$1,460,000

• 2007-2009. UGC Area of Excellence Scheme. AoE on Center for Plant and Agricultural Biotechnology-HK$25.0M (as co-I, PI: Prof. Samuel SM Sun)

• 2006-2009. GRF. An Integrated Functional Genomics Approach towards the Understanding of Artemisinin Metabolism. HK$1,052,500

• 2006-2008. NSFC. Plant osmotic stress-response gene mining and functional analysis. RMB 260,000

• 2005-2006. CUHK Direct grant. EST database approach for gene discovery in Artemisia annua glandular trichomes. HK$107,916.