Education

Current Positions

• Associate Professor, School of Life Sciences, CUHK
• Programme Director, Biotechnology, Entrepreneurship and Healthcare Management Programme, CUHK

Research Interests

• Vascular and metabolic biology
• Stem cell biology
• Cardiovascular regeneration

Representative Publications

Full Publication List

(ORCID: 0000-0002-4514-3780; Publons ID: Q-4512-2018)

1. Wang, X., Xu, Z., Wang, J., Wu, C., Zhang, L., Qian, C., … Wong, W. T & Xiang, D. (2025). A Mitochondria‐Targeted Biomimetic Nanomedicine Capable of Reversing Draug Resistance in Colorectal Cancer Through Mitochondrial Dysfunction. Advanced Science, 12(13), 2410630.
2. H Zhu, L Ouyang, Y Huang, J Tan, C Liu, Q Wang, R Huang, Wong WT, X Liu, H Pan, Y Liao. (2025). Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression. Advanced Science, 2414676.
3. He, C., Zhu, R., He, L., Chook, C. Y. B., Li, H., Leung, F. P., … & Wong, WT^#. (2025). Asperuloside as a Novel NRF2 Activator to Ameliorate Endothelial Dysfunction in High Fat Diet-Induced Obese Mice. Antioxidants & Redox Signaling, 42(1-3), 77-96. ^#Corresponding author
4. Wang, L., Li, Q., Leung, L. K., & Wong, WT^#. (2025). Licorice Extract Isoliquiritigenin Increased Cytosol Calcium and Induced Apoptosis in Colon Cancer Cells via Transient Receptor Potential Vanilloid‐1. Cancer Medicine, 14(5), e70705.^#Corresponding author
5. Li, Q., Li, H., Zhu, R., Cho, W. C. S., Yao, X., Leung, F. P., Tse, G., Leung, L. K., & Wong, WT^#. (2024). TRPV2 calcium channel promotes breast cancer progression potential by activating autophagy. Cancer Cell International, 24(1), 324. ^#Corresponding author
6. He, C., Zhang, Q., Zhu, R., Tse, G., & Wong, WT^#. (2024). Asperuloside activates hepatic NRF2 signaling to stimulate mitochondrial metabolism and restore lipid homeostasis in high fat diet-induced MAFLD. European Journal of Pharmacology, 983, 177003. ^#Corresponding author
7. Wang, L., Zhu, R., He, C., Li, H., Zhang, Q., Cheung, Y. M., Leung, F. P., & Wong, WT^#. (2024). Licorice Extract Isoliquiritigenin Protects Endothelial Function in Type 2 Diabetic Mice. Nutrients, 16(18), 3160. ^#Corresponding author
8. Lin, Y., He, C., Liu, J., Chung, H. Y., Chen, Z. Y., & Wong, WT^#. (2024). Houttuynia cordata Thunb. Extracts Alleviate Atherosclerosis and Modulate Gut Microbiota in Male Hypercholesterolemic Hamsters. Nutrients, 16(19), 3290. ^#Corresponding author
9. Chen, F. M., Li, H., Chung, D. L. S., Mak, A. T., Leung, F. P., Chan, H. Y. E., & Wong, WT^#. (2024). IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells. Clinical and Experimental Pharmacology and Physiology, 51(1), 30-39. ^#Corresponding author
10. Li, H., He, C., Zhu, R., Chen, F. M., Wang, L., Leung, F. P., … & Wong, WT^#. (2023). Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling. Cell Reports, 42(8). ^#Corresponding author
11. Chen FM, Tse JK, Jin L, Chook CYB, Leung FP, Tse G, Woo CW, Xu A, Chawla A, Tian XY, Chan TF, Wong WT^#(2022). Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration. Theranostics. 2022 Jan 1;12(3):1161-1172. doi: 10.7150/thno.67515. PMID: 35154480; PMCID: PMC8771554.^#Corresponding author
12. Tian Q, Leung FP, Chen FM, Tian XY, Chen ZY, Tse G, Ma S, Wong WT^#(2021). Butyrate protects endothelial function through PPARd/miR-181b signaling. Pharmacol Res. 169:105681. doi: 10.1016/j.phrs.2021.105681 ^#Corresponding author
13. Chook CYB, Chen FM, Tse G, Leung FP, Wong WT^#(2021). Crocodile blood supplementation protects vascular function in diabetic mice. Food Production, Processing and Nutrition. 3:19. doi: 10.3389/fcvm.2021.671666  ^#Corresponding author
14. Chen MZ, Tse G, Wong WT^#(2021). Interleukin-4 increases phagocytosis of necrotic cells by macrophages through scavenger receptor CD36. Clin Exp Pharmacol Physiol. 48(1):129-136. doi: 10.1111/1440-1681.13399 #Corresponding author
15. Kho J, Tian XY, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH (2018). Argininosuccinate lyase deficiency causes an endothelial-dependent form of hypertension. Am J Hum Genet.103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008
16. Tse G, Liu T, Li G, Keung W, Yeo JM, Chan YW, Yan B, Chan YS, Wong SH, Li RA, Zhao J, Wu KK, Wong WT^#(2017). Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.  8:85341-85352. doi: 10.18632/oncotarget.19675 ^#Corresponding author
17. Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP (2017). Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. eLife. 2017; 6. doi: 10.7554/eLife.23588
18. Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y, Wong WT^#(2016). E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. 2016 Mar 9;6:22910. doi: 10.1038/srep22910  ^#Corresponding Author

Research Grants

1. PI, Strategic Development and Collaborative Project (Innovation and Technology Commission via SKLA), Dietary seleno-amino acid uptake suppresses atherosclerotic progression via promoting M2 polarization. HKD$500,000. 04/2025 – 03/2027
2. PI, Chinese Medicine Development Fund (Health Bureau, Hong Kong Government), 中藥揮發性香氣成分的表徵及其在品質控制中的應用. HKD$1,529,800. 01/2025-12/2026
3. PI, Strategic Development and Collaborative Project (Innovation and Technology Commission via SKLA), New Therapeutic Insights into the Effects of Umbelliferone in Ameliorating Vascular Dysfunction in an animal model of Postmenopausal Syndrome. HKD$500,000. 03/2023 – 04/2025
4. PI, General Research Fund (GRF), Endothelial leptin resistance exacerbates vascular dysfunction through attenuating PD-L1 expression, RGC, HKD$1,180,218, 01/01/2023-31/12/2025
5. PI, General Research Fund (GRF), Type 2 Innate Signals Regulate Immune Populations Conducive for Neonatal Heart Regeneration, RGC, HKD$920334, 01/01/2020-31/12/2021
6. PI, 國家自然科學基金 – 面上項目, Research on protective effect and mechanisms of butyrate on vascular biology, National Natural Science Foundation (NSFC) of China, RMB$550000, 01/01/2020-21/12/2023
7. Co-I, General Research Fund (GRF), How can we handle DNA damage induced by toxic RNAs? (Edwin Chan, PI), RGC, HKD$1097419, 01/01/2020-30/06/2022
8. Co-PI, Collaborative Research Fund (CRF), The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong (Liwen Jiang, PC), RGC, HKD$7439308, 30/06/2020-29/06/2023
9. PI, Early Career Scheme (RGC), PPARd activation attenuates endothelial inflammation by up-regulating miR-181b, RGC, HKD$1263098, 01/01/2018-31/12/2020
10. PI, NSFC/RGC Joint Research Scheme (Conference Grant), N_CUHK453/17, Cardiovascular Calcium Signaling Pathway: Role in Health and Disease, RGC, HKD$250000, 01/05/2017-30/06/2018

Patents

1. Wong WT, Li Huixian, He Chufeng, Cheung Yiu Ming (2025) Leveraging type 2 cytokines to enhance cell-based therapy for peripheral arterial diseases. US Non-provisional Patent, No. 19/240284 (Supported by Patent Application Fund of The Chinese University of Hong Kong)
2. Wong WT, Li Huixian, He Chufeng, Cheung Yiu Ming (2025) Leveraging type 2 cytokines to enhance cell-based therapy for peripheral arterial diseases. PCT patent, No. PCT/CN2025/102031.
3. Wong WT, He Chufeng (2024) Asperuloside as an agent for improving vascular and metabolic function in obesity: role of NRF2 activation. US non-provisional No. 18/986220 (Supported by Patent Application Fund of The Chinese University of Hong Kong)
4. Wong WT, Li Huixian, He Chufeng, Cheung Yiu Ming (2024) Leveraging type 2 cytokines to enhance cell-based therapy for peripheral arterial diseases. US provisional Patent, No: 63/661755
5. Wong WT, He Chufeng (2023) Asperuloside as a Promising Clinical Agent for Improving Endothelial Function in Obesity: Role of Nrf2/HO-1 Activation. US Provisional Patent, No. 63/613949

Awards

Professional Activities