Address

(Office): Room E409, Science Centre East Block
(Lab): Room 298, Science Centre South Block

 People HML
 

Phone

(Office): (852) 3943 6336
(Lab): (852) 3943 8132
Fax (852) 3943 6336
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://137.189.43.137:8080/Publications/HML-publications.htm
 

 


Education

1992 Ph.D. Northwestern University
1987 M. Phil. The Chinese University of Hong Kong
1985 B. Sc. The Chinese University of Hong Kong


Position

  • Choh-Ming Li Professor of Life Sciences, School of Life Sciences, CUHK
  • Director, Molecular Biotechnology Program, CUHK
  • Director, State Key Laboratory of Agrobiotechnology (CUHK)
  • Director, Institute of Environment, Energy and Sustainability, CUHK
  • Director, RGC-AoE Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security, CUHK
  • Director, Center for Soybean Research, CUHK
  • Associate Director, Institute of Plant Molecular Biology & Agricultural Biotechnology, CUHK
  • Student Hostel Warden, Daisy Li Hall, New Asia College, CUHK


Research Interests

  • Climate-smart and sustainable agriculture
  • Plant and agricultural biotechnology
  • Genomic studies on crop-environment interaction 

 
Recent and Representative Publications

  • F. Cisternas*, C. Sun, C.A. Contador, S. Anders, M. Chu, N. Phan, B. Hu, Z. Liu, H.-M. Lam*, L.A. Tse. 2024. Cultural and generational factors shape Asians’ sustainable food choices: Insights from choice. Cell Rep Sustain. 1:100020.
  • M. Huang, L. Zhang, W.-S. Yung, Y. Hu, Z. Wang, M.-W. Li, H.-M. Lam. 2023. Molecular evidence of enhancer-promoter interaction involved in light responses in soybean seedlings. Plant Physiol. 193:2287-2291.
  • K. Fan, Z. Wang, C.-C. Sze, Y. Niu, F.-L. Wong, M.-W. Li, H.-M. Lam. 2023. MicroRNA 4407 modulates nodulation in soybean by repressing a root-specific ISOPENTENYLTRANSFERASE (GmIPT3). New Phytol. 240:1034-1051.
  • S. Duan, M.-W. Li, Y. Niu, C. Huang, J. Hang, D. Shi, C.K. Man, M.L. Chow, F.-L. Wong, G. Chung, H.-M. Lam. 2023. A natural non-synonymous single nucleotide polymorphism (SNP) in GmbHLH113 negates its inhibitory effect on root hair elongation in soybean. Plant J. 115:742-757.
  • M. Chu, S. Anders, Q Deng, C.A. Contador, F. Cisternas, C. Caine, Y. Zhu, S. Yang, B. Hu, Z. Liu, L.A. Tse, H.-M. Lam. 2022. The future of sustainable food consumption in China. Food Energy Secur. 12:e405
  • M. Huang, L. Zhang, L. Zhou, W.-S. Yung, Z. Wang, Z. Xiao, Q. Wang, X. Wang, M.-W. Li, H.-M. Lam. 2022. Identification of the accessible chromatin regions in six tissues in the soybean. Genomics 114:110364.
  • P.E. Bayer, B. Valliyodan, H. Hu, J.I. Marsh, Y. Yuan, T.D. Vuong, G. Patil, Q. Song, J. Batley, R.K. Varshney, H.-M. Lam, D. Edwards, H.T. Nguyen. 2022. Sequencing the USDA core soybean collection reveals gene loss during domestication and breeding. Plant Genome 15:20109.
  • S.C. Lung, S.H. Lai, H. Wang, X. Zhang, A. Liu, Z.-H. Guo, H.-M. Lam, M.-L. Chye. 2022. Ligand-dependent interaction of Class II acyl-CoA-binding proteins with lipoxygenase modulates oxylipin signaling in salt-stressed soybean. Plant Cell 34:1117-1143.
  • C. Li, W. Nong, S. Zhao, X. Lin, Y. Xie, M.-Y. Cheung, Z. Xiao, A.Y.P. Wong, T.F. Chan, J.H.L. Hui, H.-M. Lam. 2022. Differential microRNA expression, microRNA arm switching, and microRNA:long noncoding RNA interaction in response to salinity stress in soybean. BMC Genom. 23:65.
  • V. Garg, O. Dudchenko, J. Wang, A.W. Khan, S. Gupta, P.K.K. Han, R.K. Saxena, S.M. Kale, M. Pham, J. Yu, A. Chitikineni, Z. Zhang, G. Fan, C. Lui, V. Valluri, F. Meng, A. Bhandari, X. Liu, T. Yang, H. Chen, B. Valliyoan, M. Roorkiwal, C. Shi, H.B. Yang, N.C. Durand, M.K. Panday, G. Li, R. Barmukh, X. Wang, X. Chen, H.-M. Lam, H. Jiang, X. Zong, X. Liang, X. Liu, B. Liao, B. Guo, S. Jackson, H.T. Nguyen, W. Zhuang, S. Wan, X. Wang, E.L. Aiden, J.L. Bennetzen, R.K. Varshney. 2021. Chromosome-length genome assemblies of six legume species provide insights into genome organization, evolution, and agronomic traits for crop improvement. J. Adv. Res. (accepted)
  • X. Liu, A.P.K. Tai, Y. Chen, L. Zhang, G. Shaddick, X. Yan, H.-M. Lam. 2021. Dietary shifts can reduce premature deaths related to particulate matter pollution in China. Nat. Food 2:997-1004.
  • Q. Wang, X. Bao, S. Chen, H. Zhong, Y. Liu, L. Zhang, Y. Xia, F. Kragler, M. Luo, X. Li, H.-M. Lam, S. Zhang. 2021. AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana. Nucl. Acids. Res. 49:9755-9767.
  • X. Qi, B. Jiang, T. Wu, S. Sun, C. Wang, W. Song, C. Wu, W. Hou, Q. Song, H.-M. Lam, T. Han. 2021. Genomic dissection of widely planted soybean cultivars informs a new breeding strategy in post-genome era. Crop J. 9:1079-1087.
  • X. Wang, M.-W. Li, F.-L. Wong, C.-Y. Luk, C.Y.-L. Chung, W.-S. Yung, Z. Wang, M. Xie, S. Song, G. Chung, T.-F. Chan, H.-M. Lam. 2021. Increased copy number of Gibberellin 2-oxidase 8 genes reduced trailing growth and shoot length during soybean domestication. Plant J. 107:1739-1755.
  • K. Fan, J. Wong-Bajracharya, X. Lin, M. Ni, Y.-S. Ku, M.-W. Li, C. Tian, T.-F. Chan, H.-M. Lam. 2021. Differentially expressed microRNAs that target functional genes in mature soybean nodules. Plant Genome 14:e20103.
  • M. Huang, L. Zhang, L. Zhou, M. Wang, W.-S. Yung, Z. Wang, S. Duan, Z. Xiao, Q. Wang, X. Wang, M.-W. Li, H.-M. Lam. 2021. An expedient survey and characterization of the soybean JAGGED 1 (GmJAG1) transcription factor binding preference in the soybean genome by modified ChIPmentation on soybean protoplasts. Genomics 113:344-355.
  • Q. Wang, W.-S. Yung, Z. Wang, H.-M. Lam. 2020. The histone modification H3K4me3 marks functional genes in soybean nodules. Genomics 112:5282-5294.
  • S. Zhang, R. Runsheng, L. Zhang, S. Chen, M. Xie, L.Yang, Y. Xia, C. Foyer, Z. Zhao, H.-M. Lam. 2020. New insights into Arabidopsis transcriptome complexity revealed by direct sequencing of native RNAs. Nucleic Acids Res. 48:7700-7711.
  • Y.-S. Ku, M. Ni, N.B. Muñoz, Z. Xiao, P. Chen, M.-W. Li, M.-Y. Cheung, M. Xie, H.-M. Lam. 2020. GmABAS1 from soybean is a 1R-subtype MYB transcriptional repressor that regulates stomatal aperture under ABA treatment. J. Exp. Bot. 71:2970-2981.
  • C.A. Contador, S.-K. Lo, S.H.J. Chan, H-M. Lam. 2020. Metabolic analyses of nitrogen fixation in the soybean micro-symbiont Sinorhizobium fredii using constraint-based modeling. mSystems 5:e00516-19.
  • M. Xie, C.Y.-L. Chung, M.-W. Li, F.-L. Wong, X. Wang, A. Liu, Z. Wang, A.K.-Y. Leung, T.-H. Wong, S.-W. Tong, Z. Xiao, K. Fan, M.-S. Ng, X. Qi, L. Yang, T. Deng, L. He, L. Chen, A. Fu, Q. Dong, J. He, G. Chung, S. Isobe, T. Tanabata, B. Valliyodan, H.T. Nguyen, S.B. Cannon, C.H. Foyer, T.-F. Chan, H.-M. Lam.  2019. A reference-grade wild soybean genome. Nat. Commun. 10:1216.
  • C. Foyer, H.M. Lam, H. Nguyen, K. Siddique, R. Varshney, T. Colmer, W. Cowling, H. Bramley, T. Mori, J. Hodgson, J. Cooper, T. Miller, K. Kunert, B. Vorster, C. Cullis, J. Ozga, M. Wahlqvist, Y. Liang, H. Shou, K. Shi, J. Yu, N. Fodor, B. Kaiser, F.-L. Wong, B. Valliyodan, M. Considine. 2016. Neglecting legumes has compromised global food and nutritional security. Nat. Plants 2:16112.
  • M.-Y. Cheung, X. Li, R. Miao, Y.-H. Fong, K.-P. Li, Y.-L. Yung, M.-H. Yu, K.-B. Wong, Z. Chen, H.-M. Lam. 2016. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses. Proc. Natl. Acad. Sci. USA  113:2648-53.
  • X. Qi, M.-W. Li, M. Xie, X. Liu, M. Ni, G. Shao, C. Song, A.K.-Y. Yim, Y. Tao, F.-L. Wong, S. Isobe, C.-F. Wong, K.-S. Wong, C. Xu, C. Li, Y. Wang, R. Guan, F. Sun, G. Fan, Z. Xiao, F. Zhou, T.-H. Phang, X. Liu, S.-W. Tong, T.-F. Chan, S.-M. Yiu, S. Tabata. J. Wang, X. Xu, H.-M. Lam. 2014. Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing. Nat. Commun. 5:4340.
  • H.-M. Lam, J. Remais, M.-C. Fung, L. Xu, S.S.-M. Sun. 2013. Food supply and food safety issues in China. Lancet 381:2044-2053.
  • H.-M. Lam, X. Xu, X. Liu, W. Chen, G. Yang, F.-L. Wong, M.-W. Li, W. He, N. Qin, B. Wang, J. Li, M. Jian, J. Wang, G. Shao, J. Wang, S.S.-M. Sun, and G. Zhang. 2010. Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat. Genet. 42:1053-1059.


Research Grants

  • 2021-2023, GRF, Differential functions in RNA splicing by heat-responsive isoforms of PRP4KA and PRP4KB in Arabidopsis thaliana, HK$1,125,732
  • 2019-2020, ENSURE, Global Food Security, Climate Change and Resilience: An International Perspective, HK$1,000,000
  • 2018-2019, "港澳台科技創新合作" 重點專項 國家重點研發計劃, RMB$980,000
  • 2018-2020, GRF, Possible roles of a plant ribosome-associated protein on translational regulation, $1,034,257
  • 2017-2025, RGC-AoE, Center for Genomic Studies on Plant-Environment Interaction for Sustainable Agriculture and Food Security, $81,156,000
  • 2017-2019, GRF, Characterization of soybean multidrug and toxin extrusion (MATE) transporters that regulate the accumulation of flavonoid phenolic metabolites in soybean seeds, $1,181,200
  • 2016-2018, GRF, Site-directed mutagenesis to delineate the interactions of a plant regulator which loves to interact, $1,306,718
  • 2015-2017, GRF, The roles of the soybean Rj2/Rfg1 protein in the interaction with the rhizobial bacterium Sinorhizobium fredii, $878,400
  • 2013-2016, GRF, Functional dissection of a novel C2-domain protein that regulates an unconventional G-protein in plants, $1,125,842
  • 2012-2015, CRF, Genomic and molecular studies of a salinity tolerance locus in the wild soybean genome, $8,035,050
  • 2011-2013, GRF, Using a unique recombinant inbred population and genomic sequencing information to map loci controlling important agronomic traits of soybean, $2,070,000
  • 2010-2011, GRF, The functional roles of GmSAL1 in enhancing stress tolerance via regulating the basal cytosolic calcium level, $869,124
  • 2009-2010, GRF, The roles of a novel G-protein binding protein in plant defense response, $990,465
  • 2004-2007, CERG, Characterization and functional analysis of a novel NaCl-inducible purple acid phosphatase-like gene, $939,968
  • 2002-2005, CERG, Gene regulation in the signal transduction pathways of broad-spectrum bacterial blight resistance loci in rice, $876,000
  • 2000-2003, CERG, Sink-source relationship during seed development in Arabidopsis thaliana– molecular regulation of aspartate family amino acids, $1,062,600
  • 1999-2003, Molecular and biochemical characterization of a salt-tolerant soybean variety, $709,500
  • 1998-2002, CERG, Asparagine synthetase genes: their roles in plant growth and development, $1,032,000
  • 1997-1999, Ho Sin Hang Education Endowment Fund, Reclaiming the salty lands for agriculture, $250,000


Patents

U.S. Patents (Granted)

  1. Plant nitrogen regulatory P-PII polypeptides; Patent number: 6,822,079 (2004)
  2. Plant nitrogen regulatory P-PII genes; Patent number: 6,177,275 (2001)
  3. Plant glutamate receptors; Patent number: 5,824,867 (1998); 5,981,703 (1999); 5,959,174 (1999); 6,451,546 (2002)
  4. Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase; (Patent No. 7,939,712B2) (May 10, 2011)
  5. Abiotic stress tolerance conferred by J domains containing proteins (Patent No. 7,939,711B2) (May 10, 2011)
  6. Use of GmRD22-like genes to protect against abiotic stress (Patent No. 7,994,390B2) (August 9, 2011)
  7. Methods to enhance plant trauma resistance (Patent No. 7,994,392B2) (August 9, 2011)
  8. Methods to improve plant resistance to infections (Patent No. 7,994,393B2) (August 9, 2011)

China Patents (Granted)

  1. Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same (Patent No. CN1281759C) (Feb 2007)
  2. Methods to improve plant resistance to infections (Patent No. CN101686646B) (May 23, 2012)
  3. Gmrd22-like genes and use thereof to protect against abiotic stress (Patent No. CN101548013B) (March 21, 2012) 
  4. Method to alleviate abiotic stress in plants by expression of mitochondrial-targeted purple acid phosphatase (Patent No. CN101541165B) (May 15, 2013)
  5. Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. CN101553569B) (June 20, 2013) 
  6. Methods to enhance plant trauma resistance (Patent No. CN101686642B) (January 1, 2014)

Hong Kong Patents (Granted)

  1. Transgenic plant products comprising human granulocyte colony-stimulating factor and method for preparing the same; Patent number 1071908 (August 2007)
  2. Use of GmRD22-like genes to protect against abiotic stress (Patent No. 1137776) (December 2, 2012) 
  3. Methods to improve plant resistance to infections (Patent No. 1140910) (March 1, 2013)
  4. Method to alleviate abiotic stress in plants (Patent No. HK1132878) (September 19, 2013) 
  5. Abiotic stress tolerance conferred by J-domain-containing proteins (Patent No. HK1138033) (March 14, 2014)

 
Awards

  • 2023, Medal of Honor, Hong Kong SAR Government
  • 2012-2013, & 2020-2021, Research Excellence Award, The Chinese University of Hong Kong
  • 2017, Higher Education Outstanding Scientific Research Award 2016 (Science and Technology; Second Class), Ministry of Education of the People's Republic of China: Searching Functional Gene for Crop Improvement (1st Awardee)
  • 2016-2021, Outstanding Fellow of the Faculty of Science
  • 2007, Second-Class Award for Science and Technology, Zhejiang Province, People's Republic of China: Establishment and Large Scale Application of an Efficient and Safe System for Transgenic Rice Technology. (6th Awardee)
  • 2001, Second-Class Award for Scientific and Technological Achievements, Beijing City, People's Republic of China: Research and Application of Salt Tolerance Study in Soybean. (4th Awardee)
  • 1999-2000 &2005-2006, Exemplary Teaching Award, Faculty of Science, CUHK
  • 1998, Award for Excellence in Presentation, 6th Pacific Rim Biotechnology Conference and BioExpo '98
  • 1992, Raymond W. Sarber Award, American Society for Microbiology


Professional Activities

Visiting Professorships

  • 2006-present, Visiting Professor (Institute of Plant Sciences, Jilin University, China)
  • 2000-present, Visiting Research Professor (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, China)
  • 2012-present, Visiting Research Professor (Gansu Academy of Agricultural Sciences, China)
  • 2011-present, Visiting Research Professor (Institute of Economic Crops, Shanxi Academy of Agricultural Sciences, China)

Editorial Boards

  • 2021-present, CABI A&B Journal (Associate Editor)
  • 2021-2023, The Plant Genome (Associate Editor)
  • 2014-present, PLOS ONE (Academic Editor)
  • 2013-present, The Crop Journal (Associate Editor)
  • 2010-present, Soybean Science (Editorial Board)

Professional Services

  • 2023 – present, Director, Institute of Environment, Energy and Sustainability, CUHK
  • 2017 – present, Director, State Kay Laboratory of Agrobiotechnology (The Chinese University of Hong Kong)
  • 2012 – present, Director, Center for Soybean Research, CUHK
  • 2018 – present, Member, Research Committee, CUHK
  • 2019 – present, Member, Management Committee of Institute of Environment, Energy and Sustainability, CUHK
  • 2020 – 2023, Member of the Academic Committee, Key Laboratory of Germplasm Resources Conservation and Utilization, Guangdong Province
  • 2018 – present, Member of the Academic Committee, State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A & F University
  • 2019 – present, Member, Biology and Medicine Panel (Joint Research Scheme), Research Grants Council (RGC) of Hong Kong
  • 2022 – 2025, Chair, Advisory Committee of the Sustainable Agricultural Development Fund, Environment and Ecology Bureau, Government of HKSAR
  • 2016 – present, Member, Advisory Committee of the Sustainable Agricultural Development Fund, Environment and Ecology Bureau, Government of HKSAR
  • 2019 – 2025, MT Incu-Bio Assessment Panel, Hong Kong Science and Technology Parks Corporation

Major Services in Education

  • 2020 – present, member, CDC Standing Committee on STEM Education
  • 2019 – 2023, Associte Director, Guangdong Provincial College Plant Production Professional Teaching Steering Committee
  • 2019 – present, Member, Steering Committee for Internationalization of Higher Education and Engagement of Mainland China, CUHK
  • 2019 – present, School Manager, Delia Memorial School (Hip Wo)
  • 2019 – present, School Manager, Delia Memorial School (Broadway)
  • 2015 – present, School Manager, Queen Elizabeth School Old Students’ Association Tong Kwok Wah Secondary School

 

Address

(Office): Rm 180, Science Centre South Block

   People PCS 2 

Phone

(Office): (852) 3943 1363

  
Fax (852) 2603 7246  
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
  
Web  ---  
 

 

  

Education

1987 Ph.D. Imperial College, University of London
1983 M.Phil.. The Chinese University of Hong Kong
1981 B.Sc. The Chinese University of Hong Kong


Position

  • Research Professor, School of Life Sciences
  • Director, LDS YYC R & D Centre for Chinese Medicine
  • Deputy Director, Institute of Chinese Medicine
  • Master, Postgraduate Halls

 
Research Interests

  • Structure-function studies of proteins
  • Authentication, quality control and pharmacological studies of herbal material

Representative Publications

  1. Wang F, Tang YS, Cao F, Shou JW, Wong CK, Shaw PC. 3,4,5-tri-O-caffeoylquinic acid attenuates influenza A virus induced inflammation through Toll-like receptor 3/7 activated signaling pathway. Phytomedicine. 2024 Sep;132:155896. doi: 10.1016/j.phymed.2024.155896.
  2. Chan KT, Wu HY, Tin WY, But PP, Cheung SC, Shaw PC. Ethnopharmacology of five flowers herbal tea, a popular traditional beverage in Hong Kong and South China. J Ethnobiol Ethnomed. 2024 Mar 15;20(1):36. doi: 10.1186/s13002-024-00674-z.
  3. Wu HY, Wong KL, Law ST, Nong W, Chan KT, Hui JH, Lin G, Chan WH, Shaw PC. Determination of ITS1 haplotypes of Fritillariae Cirrhosae Bulbus by amplicon sequencing. Chin Med. 2024 Feb 28;19(1):33. doi: 10.1186/s13020-024-00911-3.
  4. Tang YS, Zhang C, Lo CY, Jin Z, Kong BL, Xiao MJ, Huang EF, Hu C, Shaw PC. Anti-influenza virus activities and mechanism of antrafenine analogs. Eur J Med Chem. 2023 Nov 15;260:115775. doi: 10.1016/j.ejmech.2023.115775.
  5. Shou JW, Shaw PC. Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma. Phytomedicine. 2023 Jul;115:154842. doi: 10.1016/j.phymed.2023.154842.
  6. Wang F, Kong BL, Tang YS, Lee HK, Shaw PC. Bioassay guided isolation of caffeoylquinic acids from the leaves of Ilex pubescens Hook. et Arn. and investigation of their anti-influenza mechanism. J Ethnopharmacol. 2023 Jun 12;309:116322. doi: 10.1016/j.jep.2023.116322.
  7. Xiao M, Zhang T, Cao F, Liang W, Yang Y, Huang T, Tang YS, Liu B, Zhao X, Shaw PC. Anti-influenza properties of tiliroside isolated from Hibiscus mutabilis L. J Ethnopharmacol. 2023 Mar 1;303:115918. doi: 10.1016/j.jep.2022.115918.
  8. Wu HY, Wong KH, Kong BL, Siu TY, But GW, Tsang SS, Lau DT, Shaw PC. Comparative Analysis of Chloroplast Genomes of Dalbergia Species for Identification and Phylogenetic Analysis. Plants (Basel). 2022 Apr 20;11(9):1109. doi: 10.3390/plants11091109.
  9. Kong BL, Nong W, Wong KH, Law ST, So WL, Chan JJ, Zhang J, Lau TD, Hui JH, Shaw PC. Chromosomal level genome of Ilex asprella and insight into antiviral triterpenoid pathway. Genomics. 2022 May;114(3):110366. doi: 10.1016/j.ygeno.2022.110366.
  10. Xiao M, Lim-Ho Kong B, Zhang Y, Yang Y, Lu J, Lee HK, Cao F, Shaw PC. Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract. J Ethnopharmacol. 2022 Jun 28;292:115175. doi: 10.1016/j.jep.2022.115175.
  11. Shou JW, Shaw PC. Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms. Cells. 2022 Feb 24;11(5):796. doi: 10.3390/cells11050796.
  12. Shou JW, Li XX, Tang YS, Lim-Ho Kong B, Wu HY, Xiao MJ, Cheung CK, Shaw PC. Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action. Free Radic Biol Med. 2022 Mar;181:62-71. doi: 10.1016/j.freeradbiomed.2022.01.022.
  13. Tang YS, Xu S, Chen YW, Wang JH, Shaw PC. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 Apr 19;49(7):4144-4154. doi: 10.1093/nar/gkab203.
  14. Yik MH, Wong VCT, Wong TH, Shaw PC. HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products. J Tradit Complement Med. 2021 Jul 24;11(6):598-600. doi: 10.1016/j.jtcme.2021.07.005.

 
Books

  1. Shaw, P.C., Cao, H. and Lo, Y.T. (ed.) (2023) Authentication of Chinese Medicinal Materials by DNA Technology. 2nd ed. World Scientific Publishing Co. Ltd. Singapore.
  2. 曹暉、邵鵬柱、畢培曦主編(2016) 中藥分子鑒定 - 技術與應用。694頁。人民衛生出版社。
  1. 邵鵬柱、曹暉主編 (2004)中藥分子鑒定。329頁。復旦大學出版社。
  1. Shaw, P.C., Wang, J. and But, P.P.H. (ed.) (2002) Authentication of Chinese Medicinal Materials by DNA Technology. World Scientific Publishing Co. Ltd. Singapore. (The first international reference in this field of study)


Patents

  1. Investigation of the anti-obesity effect and mechanism of Tung Choi, a common vegetable Health and Medical Research Fund, 1/6/2024-30/11/26, HK$1,478,640)
  2. 運用多指標考察市場的容易混淆中藥材(Chinese Medicine Development Fund – Industry Support Programme B2, 1/8/2023-31/7/25, HK$1,904,280)
  3. Screening and characterization of anti-influenza virus components from Hong Kong Ilex species (Health and Medical Research Fund, 1/9/2020-28/2/23, HK$1,500,000)
  4. 邵鵬柱, 鄭永唐, 黃錦波, 羅嘉懿, 王睿睿, 麥雅絲.2013. 修飾的玉米核糖體失活蛋白前體及其應用和蛋白純化方法. 中國專利CN102234638.
  5. 邵鵬柱,畢培曦,徐宏喜,陳耀文,黃家樂. 2012. 用於鑒定有毒中藥材馬錢子品種的多核苷酸序列及其使用方法.中國專利CN10124537.
  6. But, P.P.H., Xu, Y.T., Shaw, P.C., Jiang, R.W. and Hon, P.M. (2011) Method of making antitussive medicine and relieving cough. US Patent No. 7,867,998.
  7. Shaw, P.C., Wang, J., But, P.P.H., Lau, T.W. (2004) The DNA sequences of medicinal Dendrobium and the application of these sequences for species identification and authentication. Chinese Patent ZL 01 1 02434.8.
  8. Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2003) Application of RFLP of DNA for the authentication of Chinese medicinal material. Chinese patent 98100001.0.
  9. Shaw, P.C., Wang, J., But, P.P.H., Ha, W.Y., Yau, F.C.F. (2004) Sequence characterized amplified region (SCAR) test for the authentication of traditional Chinese medicinal materials. US Patent No. 6,803,215.
  10. Wang, J., Shaw, P.C., But, P.P.H., Ngai, K.F.N. (2001) Polymerase chain reaction-restriction fragment length polymorphism test for the authentication of herbal Chinese medicines. U.S. Patent No. 6,309,840.


Research Grants

  1. Investigation of the anti-obesity effect and mechanism of Tung Choi, a common vegetable (Health and Medical Research Fund, 1/6/2024-30/11/26, HK$1,478,640)
  2. 運用多指標考察市場的容易混淆中藥材(Chinese Medicine Development Fund – Industry Support Programme B2, 1/8/2023-31/7/25, HK$1,904,280)
  3. Screening and characterization of anti-influenza virus components from Hong Kong Ilex species (Health and Medical Research Fund, 1/9/2020-28/2/23, HK$1,500,000)
  4. Evaluation of anti-influenza properties of antrafenine and its analogs (Health and Medical Research Fund, 2019-22, HK$1,499,440)
  5. Molecular authentication of endangered timber samples – protocol development and evaluation on the scope of application (Environment and Conservation Fund, 2019-21, HK$1,290,562)
  6. Screening nickase enzyme candidates for the NGS technology designed by Genvida (Contract Research from Genvida (HK) Co. Ltd, 2019, $375,000)
  7. Evaluation of anti-influenza properties of antrafenine and its analogs (Health and Medical Research Fund, 2019-22, HK$1,499,440)
  8. Molecular authentication of endangered timber samples – protocol development and evaluation on the scope of application (Environment and Conservation Fund, 2019-21, HK$1,290,562)
  9. Screening nickase enzyme candidates for the NGS technology designed by Genvida (Contract Research from Genvida (HK) Co. Ltd, 2019, $375,000)
  10. Isolation and characterization of unique RNA-N glycosidases from mushroom (Research Grants Council, 2018-20, HK$1,229,089)
  11. Development of rapid screening protocol to identify shark fins from endangered species (Environment and Conservation Fund, 2016-18, HK$986,696)
  12. Isolation and characterization of unique RNA-N glycosidases from mushroom (Research Grants Council, 2018-20, HK$1,229,089)
  13. Development of rapid screening protocol to identify shark fins from endangered species (Environment and Conservation Fund, 2016-18, HK$986,696)
  14. Investigation of the antitussive effects of a folk medicine, cardiocrinum seeds. (Health and Medical Research Fund, 2015-17, $995,128)
  15. Study on the interaction of influenza A virus nucleoprotein and polymerase PB2 N-terminal region (Research Grants Council, 2015-17, $624,538)
  16. Establishment of new paradigm with feasible models in teaching and learning science for problem solving and future development (University Grants Committee, 2014-17, HK$10,000,000, as Co-PI)
  17. Structure-based drug design of anti-influenza compounds targeting influenza polymerase (Health and Medical Research Fund, 2014-16, $998,750)


Professional Activities

  • Editorial Board, Protein Engineering, Design and Selection
  • Co-Editor, Biodesign (Korea)
  • Editorial Board, Toxins (Basel)

 

Rankings

  • Named among world’s top 2% scientists by Stanford University (2023)
  • Ranked 297 by Research.com among scientists in the field of Biology and Biochemistry in China (2023)

 

Email

 This email address is being protected from spambots. You need JavaScript enabled to view it.

 People CKW
 

 

 
   
   
 

Education

1985 Ph. D. University of Toronto
1980 M. Sc. University of Ottawa
1978 B. Sc. University of Toronto

Position

  • Adjunct Professor, School of Life Sciences

Research Interests

 

  • Ecology of marine plankton
  • Feeding behavior of marine zooplankton
  • Trophic roles of microzooplankton and mesozooplankton
  • Genetic diversity of picophytoplankton
  • Ecotoxicology  

Representative Publications

  • Lie AAY, Wong CK: Selectivity and grazing impact of microzooplankton on phytoplankton in two subtropical semi-enclosed bays with different chlorophyll concentrations. J Exp Mar Biol Ecol 2010, 390:149-159.
  • Liu H, Chen M, Suzuki K, Wong CK, Chen B: Mesozooplankton selective feeding in subtropical coastal waters as revealed by HPLC pigment analysis. Mar Ecol Prog Ser 2010, 407:111-123.
  • Cheung MK, Au CH, Chu KH, Kwan HS, Wong CK: Composition and genetic diversity of picoeukaryotes in subtropical coastal waters as revealed by 454 pyrosequencing. ISME J 2010, 4:1-7.
  • Cheung MK, Chu KH, Li CP, Kwan HS, Wong CK: Genetic diversity of picoeukaryotes in a semi-enclosed harbour in the subtropical western Pacific. Aquat Microb Ecol 2008, 53:295-305.
  • Tse P, Nip THM, Wong CK: Nursery function of mangrove: a comparison with mudflat in terms of fish species composition and fish diet. Estuar Coast Shelf Sci 2008, 80:235-242.
  • Wong CK, Li VCY, Chan A: Diel cycles of reproduction and vertical migration in the marine cladocerans Pseudevadne tergestina and Penilia avirostris. J Plankton Res 2008, 30:65-73.
  • Tse P, Hui SY, Wong CK: Species composition and seasonal abundance of Chaetognatha in the subtropical coastal waters of Hong Kong. Estuar Coast Shelf Sci 2007, 73:290-298.
  • Hwang JS, Souissi S, Tseng L-C, Seuront L, Schmitt FG, Fang L-S, Peng S-H, Wu C-H, Hsiao S-H, Twan W-H, Wei T-P, Kumar R, Fang T-H, Chen Q-C, Wong CK: A 5-year study of the influence of the northeast and southwest monsoons on copepod assemblages in the boundary coastal waters between the East China Sea and the Taiwan Strait. J Plankton Res 2006, 28:943-958.
  • Wong CK, Liu X-J, Siu YY, Hwang J-S: Study of selective feeding in the marine cladoceran Penilia avirostris by HPLC pigment analysis. J Exp Mar Biol Ecol 2006, 331:21-32.
  • Hwang J-S, Wong CK: The China Coastal Current as a driving force for transporting Calanus sinicus (Copepoda: Calanoida) from its population centers to waters off Taiwan and Hong Kong during the winter NE monsoon period. J Plankton Res 2005, 27:205-210.

Research Grants

  • 2009-2011, GRF, Microzooplankton grazing impact on phytoplankton in Tolo Harbour, $562,128
  • 2009-2010, Agriculture, Fisheries & Conservation Department, HKSAR Government, Provision of Services on water quality monitoring in marine parks and marine reserve, $174,600
  • 2002-2003, Agriculture, Fisheries & Conservation Department, HKSAR Government, Provision of Services on water quality monitoring in marine parks, marine reserve and other ecological significant areas, $592,704

 Awards

  • 2005, Exemplary Teaching Award, Faculty of Science, CUHK

Professional Activities

  • Member, Advisory Committee on Review and Development of Marine Water Quality Objectives: Feasibility Study, Environmental Protection Department (2009-2010)
  • Member, Tide/HAB Expert Advisory Group, Agriculture, Fisheries and Conservation Department (2008-2010)

Others

  • President, Chinese University Teachers’ Association
  • Member, Executive Committee, Federation of HK Higher Education Staff Association

 

 

 

 

 

 

 

 

 

Address

(Office): Rm 289, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People WKB r1 

Phone

(Office): (852) 3943 8024
(Lab): (852) 3943 8073
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web http://kbwongcuhk.wordpress.com
 

 

Education

1997 Ph. D. University of Cambridge
1993 M. Phi. The Chinese University of Hong Kong
1990 B. Sc. The Chinese University of Hong Kong


Position 

  • Professor, School of Life Sciences
  • Assembly of Fellow, S.H. Ho College


Research Interests

  • Using structural biology (NMR, X-ray crystallography and cryo-EM) to understand the molecular mechanism of life
  • The maturation pathway of urease
  • Vacuolar sorting in plant cells
  • Protein Engineering, Design, Simulation and Modelling

 
Representative Publications

  1. Yap Shing Nim, Ivan Yu Hang Fong, Justin Deme, Ka Lung Tsang, Joseph Caesar, steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M. Lea*, Kam-Bo Wong*. (2023) Delivering a toxic metal to the active site of urease. Science Advances, 9(16):eadf7790.
  2. Lei Yang, Ka-Ming Lee, Conny Wing-Heng Yu, Hirotatsu Imai, Andrew Kwok-Ho Choi, David K Banfield, Kosuke Ito, Toshio Uchiumi, Kam-Bo Wong*. (2022) The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation. Nucleic Acids Res, 50:5335-5348.
  3. Ka Lung Tsang, Kam-Bo Wong*. (2022) Moving nickel along the hydrogenase–urease maturation pathway. Metallomics, 15(5):mfac003
  4. Hsi-En Tsao, Shu Nga Lui, Anthony Hiu-Fung Lo, Shuai Chen, Hiu Yan Wong, Chi-Kin Wong, Liwen Jiang, and Kam-Bo Wong*. (2022) Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins. Proc Natl Acad Sci USA, 119:e2111281119.
  5. Shuangli Sun, Lanlan Feng, Kin Pan Chung, Ka-Ming Lee, Hayley Hei-Yin Cheung, Mengqian Luo, Kaike Ren, Kai Ching Law, Liwen Jiang, Kam-Bo Wong, Xiaohong Zhuang. (2021) Mechanistic insights into an atypical interaction between ATG8 and SH3P2 in Arabidopsis thaliana. Autophagy, 18(6):1350-1366.
  6. Kwok-Ho Andrew Choi, Lei Yang, Ka-Ming Lee, Conny Wing-Heng Yu, David K Banfield, Kosuke Ito, Toshio Uchiumi, Kam-Bo Wong*. (2019) Structural and Mutagenesis Studies Evince the Role of the Extended Protuberant Domain of Ribosomal Protein uL10 in Protein Translation. Biochemistry, 58:3744-3754.
  7. Yuen MH, Fong YH, Nim YS, Lau PH, Wong KB*. (2017) Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation. Proc Natl Acad Sci USA, 114:E10890–E10898
  8. Cheung MY, Li X, Miao R, Fong YH, Li KP, Yung YL, Yu MH, Wong KB*, Chen Z*, Lam HM*. (2016) ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses.  Proc Natl Acad Sci USA. 113:2648-53
  9. Luo F, Fong YH, Zeng Y, Shen J, Jiang L, Wong KB*. (2014) How vacuolar sorting receptor proteins interact with their cargo proteins: crystal structures of apo and cargo-bound forms of the protease-associated domain from an Arabidopsis vacuolar sorting receptor. Plant Cell, 26:3693-708
  10. Fong YH, Wong HC, Yeun MH, Lau PH, Chen YW, Wong KB*. (2013) Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease. PLoS Biol, 11:e1001678.
  11. Lee KM, Yusa K, Chu LO, Yu, CWH, Oono M, Miyoshi T, Ito K, Shaw PC, Wong KB*, Uchiumi T*. (2013) Solution structure of human P1•P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome. Nucleic Acids Res, 41:8776-8787
  12. Chuck CP, Chen C, Ke Z, Wan DC, Chow HF, Wong KB*. (2013) Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases. Eur J Med Chem, 59:1-6.
  13. Lee, K.M., Yu, W.H., Chiu, Y.H., Sze, K.H., Shaw, P.C., Wong, K.B*. (2012) Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex, Nucleic Acids Res, 40:3172-82.
  14. Fong, Y.H., Wong, H.C., Chuck, C.P., Chen, Y.W., Sun, H., Wong, K.B.* (2011) Assembly of the preactivation complex for urease maturation in Helicobacter pylori: Crystal Structure of the UreF/UreH complex, J Biol Chem 286:43241 (Selected as paper of the week).
  15. Chan C.H., Yu, T.H., Wong, K.B.* (2011) Stabilizing salt-bridge enhances protein thermostability by reducing the heat capacity change of unfolding. PLoS One 6:e21624.
  16. Lam SY, Yeung RCY, Yu TH, Sze KH, Wong KB* (2011) A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity. PLoS Biol 9:e1001027
  17. Lee KM, Yu CW, Chan DS, Chiu TY, Zhu G, Sze KH, Shaw PC, Wong KB.* (2010) Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk. Nucleic Acids Res, 38:5206-5216.
  18. Too PH, Ma MK, Mak AN, Wong YT, Tung CK, Zhu G, Au SW, Wong KB*, Shaw PC*. (2009) The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome. Nucleic Acids Res, 37:602-610.
  19. Chan DS, Chu LO, Lee KM, Too PH, Ma KW, Sze KH, Zhu G, Shaw PC, Wong KB* (2007) Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses. Nucleic Acids Res, 35:1660-1672.
  20. Lee CF, Makhatadze GI, Wong KB* (2005) Effects of charge-to-alanine substitutions on the stability of ribosomal protein L30e from Thermococcus celer. Biochemistry, 44:16817-16825.
  21. Lee CF, Allen MD, Bycroft M, Wong KB* (2005) Electrostatic interactions contribute to reduced heat capacity change of unfolding in a thermophilic ribosomal protein L30e. J Mol Biol, 348:419-431.
  22. Cheung YY, Lam SY, Chu WK, Allen MD, Bycroft M, Wong KB* (2005) Crystal structure of a hyperthermophilic archaeal acylphosphatase from Pyrococcus horikoshii–structural insights into enzymatic catalysis, thermostability, and dimerization. Biochemistry, 44:4601-4611.
  23. Wong KB*, Lee CF, Chan SH, Leung TY, Chen YW, Bycroft M (2003) Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeon Thermococcus celer. Protein Sci, 12:1483-1495.
  24. Chen YW, Bycroft M, Wong KB* (2003) Crystal structure of ribosomal protein L30e from the extreme thermophile Thermococcus celer: thermal stability and RNA binding. Biochemistry, 42:2857-2865.


Research Grants

2024-2026, GRF, Structural basis of cross-talking between the hydrogenase and urease maturation pathway, $1,595,040

2023-2025, GRF, How the receptor-homology-transmembrane-RING-H2 protein (RMR) recognizes and sorts its specific cargo to the vacuoles?, $1,180,218

2021-2024, GRF, Structural basis of specific interactions among metallochaperones that facilitate the nickel delivery in the urease maturation pathway, $1,175,732

2019-2022, CRF, A state-of-the-art X-ray diffraction facility for structural biology research in Hong Kong, $2,306,960

2018-2020, GRF, How SH3P2 interacts with ATG8 in the autophagosome biogenesis in Arabidopsis, $1,274,389

2017-2019, GRF, How the C-terminal vacuolar sorting detainment (ctVSD) of plant storage proteins is recognised by sorting receptors, $1,124,086

2016-2018, GRF, Structure-function study of eukaryotic proteins eL12 and P0 and their roles in protein translation, $974,892

2015-2017, GRF, Structure-function studies of urease accessory protein UreG - elucidating the conformational changes that couple GTP hydrolysis to urease maturation, $634,168

2014-2016, HMRF, Structure-based discovery of inhibitors of Helicobacter pylori urease maturation, $994,522

2013-2015, GRF, How vacuolar sorting receptor (VSR) proteins recognize their cargo-proteins - structure-function study of the ligand-binding domain of Arabidopsis VSR1 protein, $1,168,250

2012-2014, GRF, Structure-function studies of Helicobacter pylori urease accessory proteins UreF and UreH - protein engineering studies and structure determination of the ternary UreG/UreF/UreH complex, $1,050,000

2010-2012, GRF, Structure-function study of P-complex in eukaryotic ribosomal stalk – structure determination of the dimerization domain of P1/P2 complex by NMR spectroscopy, $1,333,220

2010-2011, RFCID, Profiling of substrate-specificity and rational design of broad-spectrum peptidomimetic inhibitors for main proteases of coronaviruses, $799,092

2008-2011, UGC Special Equipment Grant, Acquiring a high-field NMR spectrometer for chemical and structural biology – from macromolecular structures and dynamics to biomolecular interactions, $10,000,000

2008-2009, RFCID, Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease, $775,008

2008-2010, GRF, Does Charge-charge interaction contribute more to protein stability at high temperatures? $639,261

2007-2009, GRF, Structure-function of hydrogenase maturation factor B (HypB) – structure determination of HypB by X-ray crystallography. $654,500

2006-2009, GRF, Is the reduced catalytic efficiency of a thermophilic acylphophsphatase a necessary consequence of enhanced stability and rigidity? $1,290,183

2003-2006, GRF, Structure-function study of ribosomal protein P2 – structure determination of human P2 by NMR spectroscopy, $1,491,000

2002-2005, GRF, Structural basis of thermostability of proteins – protein engineering of a thermophilic protein from a hyperthermophilic archaea Thermococcus celer, $1,394,000

2000-2003, GRF, Structure-function of a novel RNA binding motif - structure determination of a ribosomal protein L30e from Thermococcus celer by multi-dimensional NMR spectroscopy, $1,015,200

 


Professional Activities

Editoral Board, The Journal of Microbiology
Editoral Board, Protein Engineering, Design and Selection

 

Address

(Office): Rm 621, Mong Man Wai Building

People WPK
 

Phone

(Office): (852) 3943 6383
Fax (852) 2603 5767
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web
 

 

Education

Ph.D. in Microbiology     University of California at Davis
B.Sc. in Biology & M.Phil. in Biology (Microbiology)    The Chinese University of Hong Kong


Position

  • Emeritus Professor, School of Life Sciences, CUHK
  • Associate Director, Environmental Science Programme, CUHK


Research Interests

  • Photocatalytic Treatment for Environmental/ Water Purification
  • Environmental Technology
  • Environmental Microbiology / Biotechnology


Representative Publications (2011-present)

  • Xia Dehua, An Taicheng, Li Guiying, Wang Wanjun, Zhao Huijun, Wong Po Keung. 2016. Synergistic photocatalytic inactivation mechanisms of bacteria by graphene sheets grafted plasmonic Ag-AgX (X= Cl, Br, I) composite photocatalyst under visible light irradiation. Water Research 99:149-161
  • Ng Tsz Wai, Zhang Lisha, Liu Jianshe, Huang Guocheng, Wang Wei, Wong Po Keung. 2016. Visible-light-driven photocatalytic inactivation of Escherichia coli by magnetic Fe2O3-AgBr. Water Research 90:111-118.
  • Sun Hongwei, Li Guiying, An Taicheng, Zhao Huijun, Wong Po Keung. 2016. Unveiling the photoelectrocatalytic inactivation mechanism of E. coli: Convincing evidence from responses of parent and anti-oxidation single gene knockout mutants. Water Research 88:135-143.
  • Huang Guocheng, Xia Dehua, An Taicheng, Ng Tsz Wai, Yip Ho Yin, Li Guiying, Zhao Huijun, Wong Po Keung. 2015. Dual roles of capsular extracellular polymeric substances in the photocatalytic inactivation of Escherichia coli: Comparison of E. coli BW25113 with its isogenic mutants. Applied and Environmental Microbiology 81:5174-5183
  • Xia Dehua, Shen Zhurui, Huang Guocheng, Wang Wanjun, Yu Jimmy C., Wong Po Keung. 2015. Red phosphorus: An earth-abundant element photocatalytst for “green” bacterial inactivation under visible light. Environmental Science & Technology 49:6264-6273
  • Xia Dehua, Ng Tsz Wai, An Taicheng, Li Guiying Li, Li Yan, Yip Ho Yin, Zhao Hunjun, Lu Anhuai, Wong Po Keung. 2013. A recyclable mineral catalyst for visible-light-driven photocatalytic inactivation of bacteria: Natural magnetic sphalerite. Environmental Science & Technology 47:11166-11173.
  • Wang Jun-Jian, Liu Xin, Ng Tsz Wai, Xiao Jie-Wen, Chow Alex T., Wong Po Keung. 2013. Disinfection byproducts formation from disinfecting pure bacterial cells and pipeline biofilms. Water Research 47:2701-2709.
  • Gao Minghui, An Taicheng, Li Guiying, Nie Xin, Yip Ho-Yin, Zhao Huijun, Wong Po Keung. 2012. Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli. Water Research 46:3951-3957.
  • Wang Wanjun, Yu Ying, An Taicheng, Li Guiying, Yip Ho Yin, Yu Jimmy C., Wong Po Keung. 2012. Visible-light-driven photocatalytic inactivation of E. coli K-12 by bismuth vanadate nanotubes: Bactericidal performance and mechanism. Environmental Science & Technology 46:4599-4606.
  • Chen Yanmin, Lu Anhuai, Li Yan, Zhang Lisha, Yip Ho Yin, Zhao Huijun, An Taicheng, Wong Po Keung. 2011. Naturally occurring sphalerite as a novel cost-effective photocatalyst for bacterial disinfection under visible light. Environmental Science & Technology 45:35689-2695.


Research Grants

2016-2018

Research Grant Council-General Research Fund (GRF)

A Comparative Study of Natural Magnetic Minerals for Efficient and Cost-Effective Visible-Light-Driven Photocatalytic Disinfection of Bacteria

HK$ 942,547

2015-2019

National Natural Science Foundation of China (NSFC)

Environmental Geochemical Transformation Mechanism of Typical Antibiotic-Resistant Bacteria and Antibiotic-Resistance Genes onto the Mineral Interface under the Light Irradiation (CUHK Principal Investigator)

RMB 740,000
2015-2017 ITSP Tier 3 Scheme  An Integrated Technology of Simultaneous Visible-Light-Driven Photocatalytic Dye Degradation and Hydrogen Production  HK$ 1,399,032 (plus HK$ 469,452 for two internships)

2014-2015

ITSP Tier 3 Scheme

Application of Natural Magnetic Sphalerite for Visible-Light-Driven Photocatalytic Disinfection

HK$ 1,249,999 (plus HK$ 263,651 for an internship)

2014-2017

Agricultural and Food Research Initiatives (AFRI) Fund, US Department of Agriculture, USA

Impacts of Prescribed Fire on Polycyclic Aromatic Hydrocarbon Production and Contaminant Phototransformation Reactions in Coastal Plain (CUHK Principal Investigator)

US$ 499,324

2014-2017

National Natural Science Foundation of China (NSFC)

Environmental Behavior of Typical Phenolic BFRs and its Enhancement Degradation Mechanism by Isolated Bacteria (CUHK Principal Investigator)

RMB 1,000,000

2014-2017

NSFC

Study on the Control of Environmental Benign Degradation Pathway for PAEs by New Bismuth Series Photocatalysts under Solar Light (CUHK Principal Investigator)

RMB 820,000

2011-2014

Research Grant Council-General Research Fund (GRF)

Visible-light-driven Photocatalytic Disinfection of Bacteria by Natural Sphalerite

HK$ 1,090,183

2010-2013

GRF

Balancing of Bacteria and Disinfection Byproducts Contamination in Municipal Water Supply

HK$ 775,477

2008-2011

National Natural Science Foundation of China

Formation of Byproducts from Cellular Materials during Bacterial Disinfection (CUHK Principal Investigator)

RMB 350,000

2007-2009

Guangdong Technology Fund

Study on the Production of Disinfection Byproducts(s) of Various Drinking Water Disinfection Processes (CUHK Principal Investigator)

RMB 50,000

2006-2009

Research Grant Council- Competitive Earmarked Research Grant (CERG)

Development of Immobilized Photocatalyst for Disinfection of Pathogenic Bacteria under Visible Light

HK$ 982,000

2005-2007

CERG

Biosynthesis of Tetrodotoxin (TTX) from TTX-producing Bacteria: A Study on the Synthetic Pathways in vivo and the Cloning of the Bacterial TTX-producing Genes (Co-investigator)

HK$ 972,049

2005-2008

Research Grant Council- Central Allocation Vote (RGC-CAV)

Bioactive Substances from Marine Microbes (CUHK Principal Investigator)

HK$ 3,470,000

2003-2005

CERG

Fuzzy Air Quality Indices for Management of Indoor Air Quality in Air Conditioned Buildings (Co-investigator)

HK$ 324,000

2003-2005

CERG

Conversion of Industrial Biomass Wastes into metal Sorbents

HK$ 781,071

2003-2006

CERG

Integrated Photochemical-Biological Treatment of Dye-containing Effluent of Textile and Dyeing Industry

HK$ 1,353,000

2002-2005

Industrial Technology Fund

Development of Advanced Photocatalytic Nano-coating Technologies for Environmental and Health Industries (Deputy Project Coordinator)

HK$ 6,600,000

2001-2004

RGC-CAV

Bioactive Substances from Marine Bacteria (CUHK Principal Investigator)

HK$ 3,500,000

2000-2002

CERG

A Novel Process for Removing and Recovering Metal Contaminants Using Intergrated Biosorption and Electrodeposition (Co-investigator)

HK$ 517,817

1999-2001

CERG

Integrated Chemical-biological Treatment of Dye-containing Effluent of Textile and Dyeing Industry

HK$ 720,500

1999-2002

RGC-CAV

Automatic Microbial Identification System (Co-investigator)

HK$ 2,980,000

1998-2000

CERG

Removal and Recovery of Metal Ions from Electroplating Effluent by a Combined Chemical-biomagnetic System

HK$ 955,000

1995-1997

CERG

Study of Magnetite-immobilised Bacterial-cell System for Removal and Recovery of Metals from Electroplating Effluent

HK$ 781,000

1992-1994

CERG

Removal and Recovery of Nickel Ion (Ni2+) from Electroplating Effluent by Bacterial Cells Immobilised in Magnetites

HK$ 542,000

1992-1995

Croucher Foundation Research Grant

Effects of Oil and Oil Dispersants on Marine Plankton in Hong Kong Waters

HK$ 1,302,000

1991-1993

CERG

Application of Microbial Technology in Degradation and Decolorization of Synthetic Dyes

HK$ 570,000

1990-1993

Croucher Foundation Research Grant

Effects of Heavy Metals on Marine Planktonic Organisms in Tolo Harbour

HK$ 603,000

1988-1991

CERG

Removal of Heavy Metals from Wastewater by Immobilized Microbial Cells

HK$ 500,000


 Professional Activities

  • Visiting Professor (Nankai University of China, Tianjin, China)
  • Visiting Professor (South China University of Technology, Guangzhou, China)
  • Visiting Professor (Central China Normal University, Wuhan, China)
  • Visiting Professor (Guangdong University of Technology, Guangzhou, China)
  • Adjunct Professor (Clemson University, South Carolina, USA)
  • Member, CAS/SAFE A International Partnership Program for Creative Research Teams of Chinese Academy of Sciences
  • Associate Editor (Journal of Environmental Sciences, Elsevier Science Ltd., USA)
  • Coordinating Editor (Environmental Geochemistry and Health, Springer, Germany)
  • Member, Editorial Board, Ecotoxicology and Environmental Safety (Elsevier Science Ltd., USA)
  • Member, Water Pollution Control Appeal Board Panel, Hong Kong SAR Government, Hong Kong
  • Member, ISO 1400 Technical Committee, Hong Kong Quality Assurance Agency (HKQAA), Hong Kong
  • Member, HKQAA-5S Scheme Technical Committee, HKQAA, Hong Kong 


Award

  • 2015, Higher Education Outstanding Scientific Research Output Award (Science and Technology) in the category of Natural Sciences (Second Class), Ministry of Education, China