Address

(Office): Room E409, Science Centre, CUHK

(Lab): Room E406, Science Centre, CUHK

 People CSW

Phone

(Office): (852) 3943 6101

(Lab): (852) 3943 6390
Fax (852) 2603 5646, (852) 2603 5745
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Education

1988 PhD, Univ Manchester, UK
1986 MPhil (Biology), The Chinese University of Hong Kong, Hong Kong
1985 Postgrad Diploma (Microbiology and Biotechnology), Univ Tokyo and Osaka Univ, Japan
1983 BSc (Biology), The Chinese University of Hong Kong, Hong Kong

Position

1993-present Associate Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)
1992 Scientific Officer (Hospital Authority, Hong Kong)
1992 Education Officer (Hong Kong AIDS Foundation, Hong Kong)
1989-1991 Lecturer (Dept of Biology, Hong Kong Baptist College, Hong Kong)
1989 Lecturer (Dept of Applied Biology, Hong Kong Polytechnic, Hong Kong)
1988 Research Associate (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)

Research Interests

  • Bioremediation using fungi
  • Conversion of wastes into fungal products, including mushrooms
  • Diversity and life strategy of fungi
  • Mushroom development and genetics  

Representative Publications

  • Lau, K. L., Tsang, Y. Y., and Chiu, S.W. (2003) Use of spent mushroom compost to bioremediate PAH-contaminated samples. Chemosphere 52:1539-1546.
  • Law, W. M., Wai, L. M., Lau, W. N., Lo, K. L. and Chiu, S.W. (2003) Removal of biocide pentachlorophenol in water system by the spent mushroom compost of Pleurotus pulmonarius. Chemosphere 52:1531-1537.
  • Moore, D. & Chiu, S.W. (2001) Filamentous fungi as food. In Exploitation of Filamentous Fungi. Eds. S.B. Pointing & D. Hyde, pp. 223-252. Fungal Diversity Press: Hong Kong.
  • Chiu, S.W., Law, S.C., Ching, M.L., Cheung, K.W. & Chen, M.J. (2000) Themes for mushroom exploitation in the 21st century: sustainability, waste management and conservation. Journal of General and Applied Microbiology 46:1-14.
  • Chiu, S.W., Wang, Z.M., Leung, T.M. & Moore, D. (2000) Nutritional value of Ganoderma extract and assessment of its genotoxicity and antimutagenicity using comet assays of mouse lymphocytes. Food and Chemical Toxicology 38:173-178.
  • Chiu, S.W. and Moore, D. (1999) Sexual development in higher fungi. In: Experimental Molecular Mycology (Eds. Oliver, R. and Schweizer, M.), pp.231-271. Cambridge University Press, Cambridge, U.K.
  • Chiu, S.W., Wang, Z.W., Chiu, W.T., Lin, F.C. and Moore, D. (1999) An integrated study of individualism in Lentinula edodes in nature and its implication for cultivation strategy. Mycological Research 103:651-660
  • Chiu, S.W., Chan, Y.H., Law, S.C., Cheung, K.T. and Moore, D. (1998) Cadmium and manganese in contrast to beneficial calcium reduce yield and nutritional values of the edible mushroom Pleurotus pulmonarius. Mycological Research 102: 449-457
  • Chiu, S.W., Ching, M.L., Fong, K.L. and Moore, D. (1998) Spent oyster mushroom substrate performs better than many mushrooms for removal of biocide pentachlorophenol. Mycological Research 102: 1553-1562.
  • Chiu, S.W., Ma, A.M., Lin, F.C. and Moore, D. (1996) Genetic homogeneity of cultivated strains of shiitake (Lentinula edodes) used in China as revealed by the polymerase chain reaction. Mycological Research 100:1393-1399.
  • Chiu, S.W. and Moore, D. (Eds) (1996) Patterns in Fungal Development. Cambridge University Press: Cambridge, U.K.
  • Chiu, S.W., Chen, M.J. and Chang, S.T. (1995) Differentiating homothallic mushroom Volvariella by AP-PCR and RFLPs. Mycological Research 99:333-336.
  • Chiu, S.W. and Poon, Y.K. (1993) Submerged production of Monascus pigments. Mycologia 85:214-218.
  • Chiu, S.W. and Moore, D. (1993) Cell form, function and lineage in the hymenia of Coprinus cinereus and Volvariella bombycina. Mycological Research 97:221-226.
  • Chiu, S.W. (1993) Evidence for a haploid life cycle in Volvariella volvacea by microspectrophotometric measurements and observation of nuclear behaviour. Mycological Research 97:1481-1485.

Research Grants

Innovation and Technology Fund
2002-2004 Biotechnological Improvement of a microbial cultivar and evidence-based diversification of Microbial products - HK$3,190,000 (PI)

Hong Kong University Grant Council (UGC) Area of Excellence (AoE)
2000-2002 AoE Project of the Plant and Fungal Biotechnology - Fermentative Production of Monascus Metabolites. HK$700,000

Research Grants Council (RGC) Earmarked Grants
1997-1999 Screening natural population of Chinese shiitake strains for present and future commercial potential. HK$686,800

Research Grants Council (RGC) University and Polytechnic Granting Council Earmarked Grants
1994-1996 A study on the diversity-generating mechanism on self-fertile mushroom, Volvariella volvacea. HK$803,000
1991-1994 Protoplasts and molecular studies on Volvariella volvacea. HK$495,000

Croucher Foundation Research Funds
1990-1993 Establishment of the genomic library, linkage map and germplasm bank for Lentinula edodes. HK$627,000

UK/HK Research Scheme, The British Council
1998-1999 A confocal laser scanning microscopic analysis on the gill development of a mushroom
1996-1997 An electron microscopic analysis of the effect of metallic pollutants on fungal propagation

Direct Grants of the Research Committee, CUHK
2000-2001 Molecular, Genetical and Physiological Characterization of Hong Kong Lingzhi, Ganoderma lucidum
1999-2000 Use of spent mushroom compost to treat pesticide pentachlorophenol
1996-1997 Dissecting the carbon metabolism in fruiting of oyster mushroom
1995-1996 Feasibility of using spent mushroom compost to treat wastewater and solid waste
1994-1995 A study on the toxic effects of metal pollutants on oyster mushrooms
1989-1990 Immunofluorescence studies on the organization of microfilaments and intermediate filaments in animal cells and in fungi during meiosis

Mainline Research Scheme, CUHK
1996-1997 A molecular analysis on the ecological impact of an introduced isolate on the natural population of Armillaria

Professional Activities

Appointments in the following Professional Organizations:
Member of the Editorial Board of the International Journal "Journal of General and Applied Microbiology" (1999-present)
Session chairperson and invited speaker in "15th International Congress on the Science and Cultivation of Edible Fungi" held in the Netherlands (2000)
Invited speaker in British Mycological Society "Millennium meeting on Tropical Fungi" held in UK (2000)
Member of the Editorial Board of the International Journal "Mycological Research" (1995-1999)
Course Instructor of the Training Course in "Advanced Mushroom Biotechnology" (Center for International Services to Mushroom Biotechnology) (1995)
Member of the Executive Committee, International Mycological Association (2002 onwards)

Membership in the following Professional Organizations:
American Society of Microbiology
British Mycological Society
World Wide Fund for Nature Hong Kong
Standard Board, Hong Kong Organic Resource Centre

 

 

Address

(Office): 903, Yasumoto International Academic Park

 People CLM
 

Phone

(Office): (852) 3943 6378
Fax (852) 2603 7732
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Web -
 

 

Education

  • 1988    Ph.D. University of Liverpool
  • 1983    M.Phil. The Chinese University of Hong Kong
  • 1981    B.Sc. The Chinese University of Hong Kong


Position 

  • Adjunct Associate Professor, School of Life Sciences
  • Ex-officio member, Committee on Campus Sustainability
  • Member, Campus Landscape Enhancement Committee
  • Member, Committee on Minor Works
  • Member, Green Campus Working Group, Green University Consortium
  • College Representative, Senate
  • Fellow, College Assembly, United College


Research Interests

  • Industrial Ecology
  • Restoration Ecology
  • Urban Ecology
  • Pollution Studies 


Representative Publications

  • Pan, M. & Chu, L.M. (2016) Adsorption and degradation of antibiotics in agricultural soil.  Science of the Total Environment 545-546: 48-56
  • Pan, L. & Chu, L.M. (2015) Life cycle assessment and energy saving potential of a vertical greenery system in Hong Kong. Building and Environment DOI: 10.1016/j.buildenv.2015.06.033
  • Zhang, H. & Chu, L.M. (2015) Seed rain and seedling survival are major factors limiting vegetation regeneration on rehabilitated quarries. Landscape and Ecological Engineering 11: 29-38
  • Pan, M., Wong, C.K.C. & Chu, L.M. (2014) Distribution of antibiotics in wastewater-irrigated soils and their accumulation in vegetable crops in the Pearl River Delta, southern China.  Journal of Agricultural and Food Chemistry 62: 11062-11069
  • Kong, L., Shi, Z. & Chu, L.M. (2014) Carbon emission and sequestration of urban turfgrass systems in Hong Kong.  Science of the Total Environment 473-474: 132-138
  • Zhou, D. & Chu, L.M. (2014) Do avian communities vary with season in highly urbanized Hong Kong?  Wilson Journal of Ornithology 126: 69-80
  • Zhang, H., Zhuang, X. & Chu, L.M. (2013) Plant recruitment in early development stages on rehabilitated quarries in Hong Kong. Restoration Ecology 21: 166-173
  • Zhang, H. & Chu, L.M. (2013) Changes in soil seed bank composition during early succession of rehabilitated quarries. Ecological Engineering 55: 43-50
  • Ng, C.W.W., Woon, K.X., Leung, A.K., & Chu, L.M. (2013) Experimental investigation of induced suction distribution in a grass-covered soil. Ecological Engineering 52: 219-223
  • Zhou, D., Fung, T. & Chu, L.M. (2012) Avian community structure of urban parks in developed and new growth areas: A landscape-scale study from Southeast Asia. Landscape and Urban Planning 108: 91-102


Research Grants

  • 2015-2017, Environment and Conservation Fund, Population status and ecology of yellow-crested cockatoo (Cacatua sulphurea) in Hong Kong, $499,940 (PI)
  • 2014-2015, Environment and Conservation Fund, Value of Hermetia illucens (black soldier fly) for food waste conversion in Hong Kong, $499,500 (PI)
  • 2013-2016, Research Grants Council (RGC) Collaborative Research Fund, Green Slope Engineering: Bioengineered, Live Cover Systems for Man-made Fill Slopes and Landfill Capillary Barriers in Hong Kong, $8,000,000 (Co-I)
  • 2011-2013, Environment and Conservation Fund, The contribution of vertical greening on human climate and carbon footprint in built environment, $1,500,400 (PI)
  • 2011-2012, CUHK Knowledge Transfer Project Fund, UGC, An electronic tree identification encyclopedia, $180,000 (PI)
  • 2010-2013, Research Grants Council (RGC) Collaborative Research Fund, Green slope engineering for Hong Kong, $5,800,000 (Co-I)
  • 2010-2012, Guangdong Provincial Funding, R&D on the key technology for resource-conserving urban greenery, Guangzhou Institute of Landscape Gardening (RMB200,000) Provincial Funding for International Collaboration (Co-I)
  • 2008-2011, Environmental Conservation Fund, Ecological sustainability of vegetated steep soil cutslopes, $788,600
  • 2003-2005, Quality Education Fund, Multi-school collaboration in the information technology for Hong Kong flora and vegetation, $1,938,000 (Co-I)
  • 2001-2002, Quality Education Fund, A web-based databases and training for Hong Kong flora and vegetation, $1,500,000 (Co-I)
  • 2000-2004, Research Grants Council (RGC) Earmarked Grants, Revegetation of newly restored landfills: Site environmental conditions and the role of native species, $650,000
  • 1996-1999, Research Grants Council (RGC) Earmarked Grants, Ecological studies of completed landfills for enhancing natural succession on the man-made habitats $692,000 (PI)
  • 1994-1997, Research Grants Council (RGC) Earmarked Grants Reclamation of fly ash lagoons: an ecological and microbiological approach, $653,000 (PI)
  • 1990-1992, Research Grants Council (RGC) Earmarked Grants, Advanced studies of sanitary landfills: restoration, leachate treatment and methane generation, $850,000 (Co-I)


Professional Activities

Government committees
9/2011-8/2015 Chairman, Country Parks Committee, Agriculture, Fisheries and Conservation Department
9/2009-8/2015 Member, Country and Marine Parks Board, Agriculture, Fisheries and Conservation Department
9/2009-8/2011 Member, Country Parks Committee, Agriculture, Fisheries and Conservation Department
9/2009-8/2011 Member, Marine Parks Education Subcommittee, Agriculture, Fisheries and Conservation Department
10/2008-9/2014 Member, Endangered Species Advisory Committee, Agriculture, Fisheries and Conservation Department
10/2006-10/2010 Member, Environment and Conservation Fund Committee, Environmental Protection Department
9/2005-8/2009 Member, Marine Mammal Conservation Working Group, Agriculture, Fisheries and Conservation Department
10/2004-10/2006 Member, Research Projects Vetting Subcommittee, Environment and Conservation Fund, Environmental Protection Department

Other organizations
10/2007-present Member, Advisory Committee, Environment & Hygiene Committee, Heung Yee Kuk

NGOs
2012-present Advisor, Hong Kong Organic Waste Recycling Center
2008-present Founding member and executive council member, Hong Kong Institute of Horticultural Science
9/2009-present Dean, Academy of Nature and Culture Education, Fung Yuen Butterfly Reserve Advisory Committee, Tai Po Environmental Association
8/2004-present Advisor, Fung Yuen Butterfly Reserve Advisory Committee, Tai Po Environmental Association

Editorial board
International Journal of Ecology, Hindawi Publishing Corporation
International Journal of Recycling of Organic Waste in Agriculture, Springer
Guest reviewers for Applied Soil Ecology, Applied Vegetation Science, Building and Environment,  Ecotoxicology and Environmental Safety, Environmental and Experimental Botany, Environmental Toxicology, Environmental Toxicology and Chemistry, Environmental Geochemistry and Health, Journal of Environmental Management, Land Degradation and Development, Restoration Ecology, Urban Forestry and Urban Greening, Waste Management


Others

Conference Presentations

  1. Chau, N.L. & Chu, L.M.  A rainfall simulation study on the erosion-reducing potential of ferns on soil slopes.  Ecological Society of Australia Annual Conference 2015, 29 Nov 2015 - 3 Dec 2015. Adelaide, Australia (oral presentation)
  2. Kong, L. & Chu, L.M. Carbon dioxide fluxes of turfgrass species in urban turfs in Hong Kong. 9th International Conference on Urban Climate (ICUC9). 20-24 July 2015, International Association for Urban Climate and American Meteorological Society, Toulouse, France. (oral presentation)
  3. Ho, Y., Wang S. & Chu, L.M.  Feeding ecology of Yellow-rested Cockatoo (Cacatua sulphurea) in Hong Kong. Annual International Conference on Ecology, Biodiversity and Environment (CEBE 2014), GSTF, 15-16 Dec 2014, Singapore. (oral presentation) (Best Research Paper)
  4. Chu, L.M. Vertical greening – Efforts and hurdles.  Eco Asia Conference, Eco Expo Asia 2014. Messe Frankfurt and Hong Kong Trade Development Council, 31 Oct 2014, AsiaWorld-Expo, Hong Kong. (oral presentation)
  5. Chu, L.M. Vertical greening in a subtropical city – System and species selection. 1st International Conference on Green Wall – Meeting the Challenge of a Sustainable Urban Future: the Contribution of Green Walls. 4-5 Sept 2014, Staffordshire University, Stoke-on-Trent, UK. (oral presentation)
  6. Pan, M. & Chu, L.M. Distribution and translocation of erythromycin in wastewater irrigated soils and vegetable crops. 2014 International Symposium on Environment and Health, 4-5 July 2014, Beijing, China. (oral presentation)
  7. Zhou, D. & Chu, L.M. Avian diversity of urban parks in Hong Kong: Effects of size, age and human disturbances. Second World Biodiversity Congress, 8-11 September 2011, Kuching, Sawarak. (poster presentation)
  8. Zhou, D. and Chu, L.M.  Does urbanization affect avian community structure of urban parks in Hong Kong?  11th National Conference of the Chinese Ornithological Society, 8-15 August 2011, Lanzhou, China. (oral presentation)
  9. Chu, L.M. Vegitecture: Urban greening for the future (Keynote speech). International Conference on Environment and Industrial Innovations (ICEII2011), 17-19 June 2011, Kuala Lumpur, Malaysia. (oral presentation)
  10. Chu, L.M. & Cheng, C.Y. Living architecture - Vertical planting on facade walls in concrete jungles. Second International Conference on Waste Engineering and Management (ICWEM2010), 13-15 Oct 2010, Tongji University, Shanghai, China. (oral presentation)
  11. Zhang, H. & Chu, L.M. Ecological development of soil microbial communities in rehabilitated quarries. 1stInternational Conference on Structures and Processes of the Initial Ecosystem Development, 20-24 Sept 2010, Cottbus, Germany. (oral presentation)
  12. Chu, L.M. Ecological restoration of quarries (Keynote speech). 2010 International Conference on Environmental Engineering and Applications (ICEEA 2010), 10-12 Sept 2010, Singapore. (oral presentation)
  13. Cheung, K.K.L. & Chu, L.M. Long-term changes in invertebrate communities after hillfire. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009. Perth, Australia. (oral presentation)
  14. Cheung, K.K.L. & Chu, L.M. Characterization of soil microbial community structure on fire-disturbed sites. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009, Perth, Australia. (poster presentation)
  15. Zhang, H. & Chu, L.M. Composition and development of aboveground vegetation and soil seed bank in rehabilitated quarries in Hong Kong. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009, Perth, Australia. (oral presentation)
  16. Chu, L.M., Cheung, K.K.L. & Szeto, S.Y. Spider assemblages of rehabilitated quarries in Hong Kong. 10th International Congress of Ecology, 16-21 August 2009, Brisbane, Australia. (oral presentation)
  17. Zhang, H. & Chu, L.M. Soil seed bank composition and development in restored quarries in Hong Kong. Ninth ISSS Conference on Seed Biology, 6-11 July 2008, Olsztyn, Poland. (oral presentation )
  18. So, I.W.Y. & Chu, L.M. Ant assemblages on rehabilitated landfills in Hong Kong. International Conference on Ants and Other Social Hymenoptera, 10-13 Oct 2007, Punjabi University, Patiala, India. (oral presentation)
  19. Chu, L.M., Wong, S.K. & Cheng, C.Y. Toxicity characterization of landfill leachate using multi-species toxicity identification evaluation. SETAC Asia Pacific Conference, 18-21 Sept 2006, Peking University, Beijing, China. (poster presentation)
  20. Chu, L.M. & Hui, M.H. Butterfly communities on restored landfills. The World Conference on Ecological Restoration. Ecological Restoration: A Global Challenge, 12-18 September 2005, Zaragoza, Spain. (oral presentation)
  21. Lau, J.K.W. & Chu, L.M. Species selection for slope revegetation. International Conference on EcoEngineering – The Use of Vegetation to Improve Slope Stability, 13-17 September 2004, Thessaloniki, Greece. (oral presentation)
  22. Chu, L.M. Ecological assessment of a constructed wetland on fly ash disposal lagoon. Seventh Intecol International Wetlands Conference, 26-30 July 2004, Utrecht, The Netherlands. (poster presentation)
  23. Chu, L.M. Nutrient availability as factor affecting ecosystem development on closed landfills. Ninth International Waste Management and Landfill Symposium, 6-10 Oct 2003, Sardinia, Italy. (oral presentation)


Postgraduate Students

Ho Ka Sin (On-going) Yellow mealworm for food waste bioconversion to insect protein (MPhil)
Wang Sifeng (On-going) Ecology of yellow-crested cockatoo in urban Hong Kong (PhD)
Hui Ling Chui (On-going) Bioengineered live cover systems for fill slopes and landfill capillary barriers (MPhil)
Pan Min (On-going) Soil behavior and plant uptake of antibiotics (PhD)
Chau Ngai Lung (On-going) Values of ferns for the bioengineering of soil cutslopes (PhD)
Pan Lan (On-going) Carbon and water footprint of vertical greening (PhD)
Kong Ling (2014) Carbon sequestration and emission of urban turfs in Hong Kong and Shenzhen  (PhD)
Lai Po Ying (2014) Selection of species and systems for water conservation and temperature reduction in vertical greening (MPhil)
Wong Chuk Kwan (2012) Tadpole assemblages in freshwater wetlands and anti-predation responses in aruran tadpoles (MPhil)
Zhou Daqing (2012) Avian community structure of urban parks in Hong Kong: Effect of urbanization and multi-scale habitat characteristics (PhD)
Guan Lijie (2011) Occurrence, fate and effects of selected pharmaceutical in sewage treatment plants (MPhil)
Cheung Kwok Leung (2011) Biodiversity and recovery of faunal communities after fire disturbance in Hong Kong (PhD)
Tsang Kwok On (2011) Is Cuscuta japonica a potential biological control agent for Mikania micrantha? (MPhil)
Zhang Hao (2010) Vegetation and soil development on rehabilitated quarries in Hong Kong (PhD)
So Wai Yan Ivy (2009) Ant communities in natural and man-made habitats in Hong Kong (MPhil)
Zou Huiling (2008) PAHs contamination of roadside soils and vegetation in Hong Kong (MPhil)
Chiu Ming Ho (2007) Soil water supplying capacity as factor affecting revegetation of cutslopes (MPhil)
Wong Man Wing (2007) Soil bioavailability of rare earth elements and their effects on tree growth (MPhil)
Tsang Chin Kan (2006) Landfill leachate irrigation: Evaluation of plant productivity and soil toxicity (MPhil)
Wong Man Shan Michelle (2006) Growth of freshwater emergents under different submergence levels (MPhil)
Yu Chi Cheung (2005) Ecological inventory and faunal communities on restored quarries (MPhil)
Ho So Man (2005) Nutrient cycling on closed landfills (MPhil)
Lau Ka Wah Joyce (2005) Species selection for cutslope revegetation (MPhil)
Cheng Chung Yin Michael (2005) Utilization of landfill leachate as an alternative source of plant nutrients (MPhil)
Chong Chun Wing John (2003) Tree planting on recently restored landfills: A study of native species (MPhil)
Wong Shiu Kai Raymond (2003) Chemical and ecotoxicological characterization of landfill leachate (MPhil)
Wong Cheuk Yuet Chiky (2003) Establishment of native plant species on restored quarries covered by completely decomposed granite in Hong Kong (MPhil)
Tsui Tsz Ki Martin (2002) Aquatic toxicity and environmental fate of glyphosate-based herbicides (MPhil)
Choi Chi Yuen (2000) Ecological studies of the cover soils on completed landfills (MPhil)
Lui Mei Kam Ada (1999) Vegetation development and performance on postclosure landfills (MPhil)
Chan Chik Yu Jack (1998) Revegetation of fly ash lagoons: An ecological approach (MPhil)
Lau Shun Shun Sam (1997) Pollution status and assimilative potential of wetlands at the Mai Po Marshes (MPhil)
Tong Suk Wah Iris (1996) Ecotoxicological and treatability studies on landfill leachate (MPhil)
Ng Ki Chi Renee (1994) Recycling of agro-industrial wastes by vermiculture (MPhil)


 

Email This email address is being protected from spambots. You need JavaScript enabled to view it. People HWS
 
 
 
 

 

Education

1985 Ph.D. State University of New York Buffalo
  M.A. State University of New York Buffalo
  B.Sc. University of Alberta

Position

  • Adjunct Associate Professor, School of Life Sciences

Research Interests

  • Chemical Carcinogenesis
  • Natural products of herbal medicines and cancer
  • Detoxifying Enzymes  

Representative Publications

  • Chen Wen Yang; Ho Wing Shing John; Huang Jian Dong and Watt Rory M
    Functional Characterization of an Alkaline Exonuclease and Single Strand Annealing Protein from the SXT Genetic element of Vibrio Cholerae. BMC Mol Biol 12, 00-15, 2011.
  • Ho, J.W., Lee, N.H.P., Chim, W.O. Effects of oxymatrine from Ku Shen on cancer cells. Anti-cancer Agents Med Chem. 9(8), 823- 828, 2009.
  • Lee N.H. and Ho, J.W. Celastrol and terpenes as anti-infective agents. Anti-infective Agents in Medicinal Chemistry. 7(2), 97-104, 2008.
  • Ho, J.W. and Meng Jie. Pharmacological activity of cardiovascular agents from herbal medicine.
    Cardiovasc and Hematol Agents Med Chem. 5(4), 273 -277, 2007
  • Ho, J.W., Recent advances in protein and peptide chemistry related to cellular regulation. Protein & Peptide Lett. Vol. 13 (5), 533 pages, 2006.
  • Leung, Y.K. and Ho, J.W. Deciphering signaling control by phosphoproteome using mass spectrometry. Prot. & Peptide Lett. 13(5), 467-470, 2006.
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Wong, K.F., Ho, J.W. Identification of histidine-60 interaction with copper in activation of chironomidae ferrochelatase Prot. & Peptide Lett. 13(5), 443-446, 2006.
  • Leung, Y.K. and Ho, J.W. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochem. Pharmacol. 63(4), 767-775, 2002.

Research Grants

  • 2009 - 2010, ITC, Establishment of platform for R&D of naturally occurring small molecules for liver cancer therapy, $674,268
  • 2009 - 2011 Contract, R&D of Naturally occurring molecules for disorder & cancer therapy, $1,800, 000
  • 2009 – 2011,GRF, Is Adolescent Idiopathic Scoliosis and Its Accompanying Low Bone Mass Associated with Vitamin-D Insufficiency? – A Case-control Study, Co-I, $498,201

Patents

  • Ho, J.W. and Lau, V. Methods for treatment and/or prevention of liver cancer with andrographolide (and) use thereof. US 08C10485.
  • Ho, J.W. A Method and composition for treatment and/or prevention of gastric ulceration and use thereof . US patent no. 08C10484US.
  • Ho, J.W., Meng, J. Compositions and Methods for treating cancer. CN2008_000460.

Awards

  • Leung Y. K. and Ho, J.W. Effects of licorice on the expression of UGT1A isozymes in rat hepatoma cells.
    FASEB J. 14(8), May 11, 2000. Boston, Annual Meeting of American Society for Biochemistry and Molecular Biology [ASBMB]
  • Leung, Y.K. and Ho, J.W. Induced expression of UDP-glucuronosyltransferase 1A8 in rat liver cells by aqueous licorice root extract.
    15th Symposium of the Protein Society, Philadelphia, July 28-Aug. 1, 2001.

Professional Activities

  • Guest Editor, Protein & Peptide Letters
  • Editor Board member,
    1. Chinese Journal of Medicine;
    2. Anti-Cancer Agents in Medicinal Chemistry;
    3. Recent Patents on Anti-Cancer Drug Discovery.
  • Reviewer, Analytical Chemistry (73 papers have been reviewed)

 

 

 

 

 

 

 

Address

(Office): Room EG03, Science Center East Block

(Lab): Room G96, Science Center South Block

 People KKM
 

Phone

(Office): (852) 3943 1008

(Lab): (852) 3943 6287
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1997 Ph. D. Department of Biochemistry, The University of Hong Kong, Hong Kong
1990 B. Sc. (Biochemistry), The University of Hong Kong, Hong Kong


Position

  • Professor, School of Life Sciences


Research Interests

  • Genetic manipulation by transgenic and gene knockout technology
  • Study of Organogenesis and Tumorigensis using mouse as model organism
  • Neural development and neuronal cell biology
  • Stem cell research

Representative Publications 

  • Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM. (2021) SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 118(6):e2009568118. doi: 10.1073/pnas.2009568118.
  • Dong X, Kwan KM. (2020) Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 13(1):104. doi: 10.1186/s13041-020-00643-z
  • Ma TC, Vong KI,Kwan KM. (2020) Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis. Cell Rep. 30(11): 3616-3624.e4. doi: 10.1016/j.celrep.2020.02.089.
  • Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM. (2017) Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun. 8:15079. doi: 10.1038/ncomms15079.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. doi: 10.1038/nature20602.
  • Zhu J, Kwan KM, Mackem S. (2016) Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A. 113(14), 3820-3825.
  • Vong KI, Leung CK, Behringer RR, Kwan KM. (2015). Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 8, 25.
  • Tong KK, Kwan KM (2013). Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol. 33(10), 1925-1937.
  • Wong YL, Behringer RR, Kwan KM (2012). Ventral limb ectoderm Smad1/Smad5 signaling functions redundantly and is required in interdigital programmed cell death. Dev Biol. 363(1), 247-257.
  • Tam WY, Leung CK, Tong KK, Kwan KM (2011). Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Neuroscience. 172, 562-571.
  • Zhao Y*, Kwan KM*, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H (2007). LIM-homeodomain proteins Lhx1, Lhx5, and their cofactor Ldb1 control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 104, 13182-13186. * equal contribution as first author
  • Kwan KM. (2002). Conditional alleles in mice: practical considerations for tissue-specific knockouts. Genesis. 32, 49-62.
  • Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP and Cheah KS. (1997). Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol. 136, 459-471.


Research Grants

Research Grants Council (RGC) Hong Kong: General Research Fund

  • 2019-2021, Functional analysis of Sox9 in choroid plexus development and regulation of cerebrospinal fluid secretion – HKD$ 971,368 (as PI)
  • 2013-2015, Functional analysis of Foxp4 in exocrine pancreas development and homeostasis in mouse - HKD$ 850,000 (as PI)
  • 2011-2013, GRF, Functional analysis of Foxp4 in Purkinje neurons of cerebellum in mice, HKD$ 1,133,900 (as PI)
  • 2010-2012, GRF, Functional analysis of Sox9 in neural progenitor cells of cerebellum in mice, HKD$ 1,195,046 (as PI)
  • 2009-2011, GRF, Functional analysis of Smad genes in granule neurons of cerebellum in mice, HKD$ 1,064,049 (as PI)
  • 2008-2010, GRF, Functional analysis of Lhx1 and Lhx5 in Purkinje neurons of cerebellum in mice, HKD$ 1,146,611 (as PI)


Research Grants Council (RGC) Hong Kong: Collaborative Research Fund

  • 2020-2023, The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong – HKD$ 7,439,308 (as Co-I)
  • 2017-2020, The First Integrated cyco-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong – HKD$ 9,500,000 (as Co-I)
  • 2014-2017, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors - HKD$ 7,044,220 (as Co-I)
  • 2013-2016, Physical Exercise Promotes Vascular Health: Impact of Mechano-Transduction and Novel endothelium-derived Regulators - HKD$ 7,700,000 (as Co-I)
  • 2012-2015, EXPO (Exocyst-positive Organelle): Dynamics, Biogenesis and Function in Plants - HKD$ 8,459,400 (as Co-I)

Research Grants Council (RGC) Hong Kong: Area of Excellence

  • 2014-2020, Center for Organelle Biogenesis and Function - HKD$ 47,250,000 (as Co-I)


Health and Medical Research Fund (HMRF)

  • 2015-2017, Investigation on ataxia disorder by using a novel genetically-modified mouse model - HKD$ 999,880 (as PI)


Awards

  • 2009 and 2013 Science Faculty Exemplary Teaching Award, The Chinese University of Hong Kong
  • 2008 The Young Researcher Award 2008, The Chinese University of Hong Kong
  • 1991-1994 The Croucher Foundation Scholarship, Hong Kong

 

 

 

Address

(Office): Rm 291, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People LKF 

Phone

(Office): (852) 3943 1106
(Lab): (852) 3943 6119
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web  
   

Education

1999 Ph.D., Chinese University of Hong Kong
1994 M.Phil., Chinese University of Hong Kong
1992 B.Sc., Hong Kong Baptist University


Position

  • Professor, School of Life Sciences
  • Program Director, MSc Programme in Biochemical and Biomedical Sciences, CUHK


Research Interests

  • Amyloid precursor protein interacting proteins in Alzheimer’s disease and neurodegenerative disorders
  • Amyloid precursor protein and its interacting proteins in neurodevelopment 
  • Protein Kinases in neurodegenerative disorders


Representative Publications

  • Chan WWR, Chow J, Chau DDL, Zhai Y and Lau KF (2025) Beclin 1-mediated autophagy is potentiated by an interaction with the neuronal adaptor FE65. Biology 14(1):97. https://doi.org/10.3390/biology14010097
  • Ng LL, Chow J and Lau KF (2024) The AICD interactome: implications in neurodevelopment and neurodegeneration. Biochem Soc Trans. 52(6):2539-2556. doi: 10.1042/BST20241510
  • Chau, DDL., Yu, Z, Chan, WWR, Zhai Y, Chang RCC, Ngo JCK, Chan HYE and Lau KF (2024) The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing. Cell. Mol. Life Sci. 81, 323.
  • Chau DD, Ng LLH, Zhai Y and Lau KF (2023) Amyloid precursor protein and its interacting proteins in neurodevelopment. Biochem Soc Trans 51(4), 1647-1659.
  • Iyaswamy A, Thakur A, Guan X, Fung T, Krishnamoorthi S, Gaurav I, Wang X, Yang Z, Lau KF, Wong M, Zhang K, Lian Q, NG R, Chen HJ and Li M (2023) Fe65 engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathogenesis of Alzheimer’s disease. Signal Transduction and Targeted Therapy 8(1):404.
  • Zhai Y, Leung KT and Lau KF (2023) Regulation of cytohesins by their interactors. Neural Regen Res 18 (10) 2186-2187.
  • Chau DDL, Li W, Chan WWR, Sun JKI, Zhai Y, Chow HM and Lau KF (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signalling. FASEB J. 36, e22594
  • Zhai Y, Chan WWR, Li W and Lau KF (2022) ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth. Open Biol (The Royal Society) 12, 220071.
  • Chan WWR, Li W, Chang RCC, and Lau KF (2020) ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1. FASEB J. 34, 16397-16413.
  • Chan WWR, Chau DLD, Li W and Lau KF (2019) Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1. Bio-protocol 9(23): e3449. DOI: 10.21769/BioProtoc.3449.
  • Chau DDL, Yung KWY, Chan WWL, An Y, Hao Y, Chan HYE, Ngo JCK and Lau KF (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035
  • Chan WW, Li W, Chau D L and Lau KF (2019) An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons. J Vis Exp. (152), e60031, doi:10.3791/60031
  • Li W, Chan, Chan WWR, Ngo JCK and Lau KF (2018) Emerging roles of neural adaptor FE65 in neurite outgrowth. Neural Regen Res. 13, 2085-2086.
  • Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE and Lau KF (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 293, 7674-7688.
  • Lee YS, Chow WNV and Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Scientific Reports 7(1):12456. doi: 10.1038/s41598-017-12334-2.
  • Chiu WY, Koon A, Ngo JCK, Chan HYE and Lau KF (2017) GULP1/CED-6 ameliorates Amyloid-β toxicity in a Drosophila model of Alzheimer's disease. Oncotarget 8, 99274-99283. doi.org/10.18632/oncotarget.20062.
  • Lee CW, Stankowski, JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW and Petrucelli L (2017) The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration 12(1):55. doi: 10.1186/s13024-017-0196-6.
  • Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
  • Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
  • Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
  • Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
  • Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
  • Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
  • Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
  • Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
  • Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
  • Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
  • Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.


Research Grants

  • 2022-2025 Collaborative Research Equipment Grant (Co-PI)
  • 2021-2024 Health and Medical Research Fund (PI)
  • 2020-2023 RGC General Research Fund (Co-I)
  • 2019-2021 RGC General Research Fund (PI)
  • 2016-2018 Health and Medical Research Fund (PI)
  • 2015-2017 Health and Medical Research Fund (Co-I)
  • 2015-2017 RGC General Research Fund (Co-I)
  • 2014-2016 Health and Medical Research Fund (PI)
  • 2013-2015 RGC General Research Fund (PI)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2014 Research Fund for the Control of Infectious Diseases (Co-I)
  • 2012-2014 RGC General Research Fund (Co-I)
  • 2011-2013 RGC General Research Fund (PI)
  • 2007-2010 RGC General Research Fund (PI)
  • 2005-2009 Motor Neurone Disease Association UK

 
Awards

  • Science Faculty Exemplary Teaching Award 2013/2014; 2018/2019
  • Croucher Foundation Fellowship 1999-2001

Professional Activities

  • Associate Editor: Frontiers in Molecular Neuroscience
  • Editorial board member: International Journal of Brain Science; SOJ Biochemistry, International Journal of Neurology Research; American Journal of Psychiatry and Neuroscience